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- Andersson, Magnus S.
(författare)
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Capillary electrophoresis methods for the separation of the basic compound lidocaine and its metabolites
- 2003
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- For the separation of the basic compound lidocaine and its metabolites a variety of capillary electrophoresis (CE) methods have been developed. This includes capillary zone electrophoresis (CZE), micellar electrokinetic chromatography (MEKC) and nonaqueous CE separations. The parameters affecting the separations were investigated and optimized.In CZE reproducible separations were obtained in both un-coated and polyacrylamide-coated fused silica capillaries using a TFA/TEA electrolyte at pH 2.5.The MEKC method: a low pH phosphate/Tris buffer containing the cationic surfactant cetyltrimethylammonium bromide (CTAB) was successfully validated in human plasma.A couple of nonaqueous methods were developed. One of the methods 70 mM ammonium formate and 2 M formic acid in acetonitrile/methanol (60:40 v/v) was used for capillary electrophoresis-electrospray mass spectrometry analysis. Reproducible determinations in human plasma were obtained. The sensitivity was improved compared to UV. The detection limits for lidocaine and the metabolites monoethylglycinexylidide (MEGX) and glycinexylidide (GX) were 69 nM, 130 nM and 337 nM respectively. Parameters such as sheath liquid composition, nebulizing gas pressure and drying gas temperature were considered.The results show that CE is a simple and powerful technique for the separation of basic compounds.
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- Andersson, Niclas S, 1971
(författare)
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A Methodology for Efficient Conceptual Design Analysis of Nonlinear Dynamic Structural Systems
- 2013
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- There is a typical requirement conflict between fuel consumption and noise and vibrations in passenger cars. Obviously the combustion engine is a major source of vibration and has an influence on vehicle emissions. Similar properties apply to the power transferring mechanical driveline system. Many driveline design concepts that aim to reduce carbon-dioxide emissions intensify and add new vibration problems, since the majority of them affect vibration sources or system damping. In conceptual design of drivelines, many possible concepts proposals are studied in parallel. This situation calls for modelling and analysis that can meet the demand for rapid virtual prototyping. Conflicting to this is the trend in which models have become extremely detailed to meet demands from others than conceptual designers. The complex behaviour of the driveline system in combination with often highly specialised component models result in system models that at their best are valid only near a few specific stationary operating points. This makes is difficult to study the effectiveness of possible component design changes in early development phases. Instead, this is first revealed during system verification testing, when fundamental design changes since long are unrealisable.This work focus on models for conceptual design, \emph{i.e.} models that are not overparameterized. The aim is to find the balance when models are as simple as possible but as accurate as required by conceptual design studies. A methodology is proposed, based on knowledge of existing automotive methods and workflow, that with provided modelling tools has the potential to serve this purpose within the nearest future.
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