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Prospective study o...
Prospective study of human papillomavirus and risk of cervical adenocarcinoma.
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- Dahlström, Lisen Arnheim (author)
- Karolinska Institutet
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- Ylitalo, Nathalie (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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- Sundström, Karin (author)
- Karolinska Institutet
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- Palmgren, Juni (author)
- Stockholms universitet,Karolinska Institutet,Matematiska institutionen
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- Ploner, Alexander (author)
- Karolinska Institutet
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- Eloranta, Sandra (author)
- Karolinska Institutet
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- Sanjeevi, Carani B (author)
- Karolinska Institutet
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- Andersson, Sonia (author)
- Karolinska Institutet
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Rohan, Thomas (author)
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- Dillner, Joakim (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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- Sparén, Pär (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2010-08-20
- 2010
- English.
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In: International journal of cancer. Journal international du cancer. - : Wiley. - 1097-0215 .- 0020-7136. ; 127:8, s. 1923-30
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Abstract
Subject headings
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- Human papillomaviruses (HPV) are established as a major cause of cervical carcinoma. However, causality inference is dependent on prospective evidence showing that exposure predicts risk for future disease. Such evidence is available for squamous cell carcinoma, but not for cervical adenocarcinoma. We followed a population-based cohort of 994,120 women who participated in cytological screening in Sweden for a median of 6.7 years. Baseline smears from women who developed adenocarcinoma during follow-up (118 women with in situ disease and 164 with invasive disease) and their individually matched controls (1,434 smears) were analyzed for HPV using PCR. Conditional logistic regression was used to estimate odds ratios (OR) of future adenocarcinoma with 95% confidence intervals (CI). Being positive for HPV 16 in the first cytologically normal smear was associated with increased risks for both future adenocarcinoma in situ (OR: 11.0, 95% CI: 2.6-46.8) and invasive adenocarcinoma (OR: 16.0, 95% CI: 3.8-66.7), compared to being negative for HPV 16. Similarly, an HPV 18 positive smear was associated with increased risks for adenocarcinoma in situ (OR: 26.0, 95% CI: 3.5-192) and invasive adenocarcinoma (OR: 28.0, 95% CI: 3.8-206), compared to an HPV 18 negative smear. Being positive for HPV 16/18 in 2 subsequent smears was associated with an infinite risk of both in situ and invasive adenocarcinoma. In conclusion, infections with HPV 16 and 18 are detectable up to at least 14 years before diagnosis of cervical adenocarcinoma. Our data provide prospective evidence that the association of HPV 16/18 with cervical adenocarcinoma is strong and causal.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics (hsv//eng)
Keyword
- Adenocarcinoma
- pathology
- virology
- Adult
- Aged
- Aged
- 80 and over
- Carcinoma in Situ
- pathology
- virology
- Case-Control Studies
- DNA
- Viral
- genetics
- Female
- Follow-Up Studies
- Humans
- Middle Aged
- Neoplasm Invasiveness
- Papillomaviridae
- classification
- genetics
- isolation & purification
- Papillomavirus Infections
- pathology
- virology
- Prognosis
- Prospective Studies
- Risk Factors
- Sweden
- Uterine Cervical Neoplasms
- pathology
- virology
- Young Adult
- cervical cancer
- HPV
- adenocarcinoma
- adenocarcinoma in situ
- prospective
- adenocarcinoma
- MATHEMATICS
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Dahlström, Lisen ...
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Ylitalo, Nathali ...
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Sundström, Karin
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Palmgren, Juni
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Ploner, Alexande ...
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Eloranta, Sandra
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Sanjeevi, Carani ...
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Andersson, Sonia
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Rohan, Thomas
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Dillner, Joakim
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Adami, Hans-Olov
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Sparén, Pär
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Mathematics
- Articles in the publication
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International jo ...
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International Jo ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet
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Stockholm University