| 1. |
- Boström, Pontus, 1982, et al.
(författare)
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SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity.
- 2007
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Ingår i: Nature cell biology. - : Springer Science and Business Media LLC. - 1465-7392 .- 1476-4679. ; 9:11, s. 1286-93
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Tidskriftsartikel (refereegranskat)abstract
- The accumulation of cytosolic lipid droplets in muscle and liver cells has been linked to the development of insulin resistance and type 2 diabetes. Such droplets are formed as small structures that increase in size through fusion, a process that is dependent on intact microtubules and the motor protein dynein. Approximately 15% of all droplets are involved in fusion processes at a given time. Here, we show that lipid droplets are associated with proteins involved in fusion processes in the cell: NSF (N-ethylmaleimide-sensitive-factor), alpha-SNAP (soluble NSF attachment protein) and the SNAREs (SNAP receptors), SNAP23 (synaptosomal-associated protein of 23 kDa), syntaxin-5 and VAMP4 (vesicle-associated membrane protein 4). Knockdown of the genes for SNAP23, syntaxin-5 or VAMP4, or microinjection of a dominant-negative mutant of alpha-SNAP, decreases the rate of fusion and the size of the lipid droplets. Thus, the SNARE system seems to have an important role in lipid droplet fusion. We also show that oleic acid treatment decreases the insulin sensitivity of heart muscle cells, and this sensitivity is completely restored by transfection with SNAP23. Thus, SNAP23 might be a link between insulin sensitivity and the inflow of fatty acids to the cell.
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| 2. |
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| 3. |
- Almeida-Santana, A., et al.
(författare)
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Does bestial make you a happy human? The impact on happiness from participation in an obstacle running event
- 2022
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Ingår i: International Journal of Event and Festival Management. - : Emerald. - 1758-2954. ; 13:4
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Tidskriftsartikel (refereegranskat)abstract
- Purpose The main research questions addressed by this study focus on Subjective Well-Being (SWB) and to what extent the individual's SWB relates to the individual's need for personal growth. Specific interest is devoted to the effects of intentions (to have personal goals) and behavior (to achieve personal goals). Design/methodology/approach Can SWB and happiness research help to explain the tremendous growth in demanding amateur sport event participation? Most research on SWB and events has, so far been undertaken on cultural events leaving a gap related to sport events, especially obstacle running events. Bestial is an obstacle race event held in Arucas on Canary Islands, Spain. Apart from competitiveness, the race also contains elements of altruism as many competitors do help each other at various obstacles along the route, in groups (mainly) teams. A sample of 700 participants answered questions about behavior, attitudes and SWB. Findings The results show significant relations between SWB and both intentions and behavior but also that intentions and behavior are not correlated. Research limitations/implications The "Bestial" is different from an average running event in some respects. It is a rather local event for Gran Canaria without international participation. For some participants it is more challenging and enduring but for others it is a team sport where one helps other team members to complete the race. In this study, these two types of participation have not been separated. The test of whether the SWB of participants is higher than the SWB of the average citizen is not satisfactory. Data for the average of SWB in Spain had to depend on a study from another year and where standard deviation was not available. Practical implications The results of this work are useful for event managers to improve their design and develop the most appropriate marketing messages. Social implications The study aims for an explanation to why demanding physical activities, such as obstacle races, are so popular. In this study of obstacle race participation, hedonia is regarded as less relevant and focus is on eudaimonia and an assumption that participants in an obstacle race have a high SWB since they can feel that they make progress towards goals. One intended contribution of this study is to distinguish between "to have a goal" and "to progress towards a goal". Thus, the model proposed is based on hypotheses that SWB is influenced by both. Two types of goals are studied: first a mainly individualistic goal of becoming physically fit and second a more altruistic goal of "becoming a better person". Originality/value In the conclusions, the importance for a happy life of simply having goals for personal growth and the value of anticipation for happiness is discussed.
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| 4. |
- Alverén, Ellen, et al.
(författare)
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Seasonal employees' intention to return and do more than expected
- 2012
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Ingår i: Service Industries Journal. - : Informa UK Limited. - 0264-2069 .- 1743-9507. ; 32:12, s. 1957-1972
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Tidskriftsartikel (refereegranskat)abstract
- Seasonal employment is important in the service industries. Having motivated and satisfied employees is fundamental when front-line employees play a key role for the customers' perceived service quality. Seasonal work differs from permanent employment in many aspects and if managed properly, this could be a competitive advantage and contribute to the success of an organization. This study focuses on seasonal employees' intention to return and to do more than expected at work as well as the relationships between certain motivational factors and job satisfaction. A survey was carried out at four ski resorts with 477 respondents. Correlation and regression analyses indicate that job satisfaction influences the intention to return but does not have a strong influence on organizational citizenship behaviour (i.e. doing more than expected at work). The results improve our understanding of seasonal workers' motivation and behaviour. The concluding part discusses managerial implications.
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| 5. |
- Andersson, Tommy D., 1947, et al.
(författare)
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Balancing value and risk within a city's event portfolio: an explorative study of DMO professionals' assessments
- 2020
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Ingår i: International Journal of Event and Festival Management. - : Emerald. - 1758-2954. ; 11:4, s. 413-432
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Tidskriftsartikel (refereegranskat)abstract
- Purpose - This study aims to advance both theory and praxis for event portfolio management in cities and destinations. An experiment has been conducted with professional event practitioners in a city to determine their opinions and strategies for balancing value and risk within their event portfolio. The first objective is to rank 14 of the city's recurring events in terms of both value and risk. Second, the events are plotted in a two-dimensional chart of value versus risk with the objective to differentiate between the 14 events. The third objective is to describe the event characteristics that event professionals associate with value and risk. Design/methodology/approach - Results derive from an experiment involving the forced Q-sort procedure and professional event managers from a city renowned as an "event capital". Empirical evidence is analysed by the constant comparative method of how events are being evaluated by ten professionals working for a DMO. Findings - Economic impact and image effects are characteristics of high-value events as is an opportunity to create relations with event owners for future collaboration. Local community involvement is important for all events. The issue of portfolio fit was a common argument for weak-value events. Research limitations/implications - Results are based on the opinions of ten DMO employees in one large city. Conclusions help build event portfolio theory. Practical implications - The results and methods are useful for event strategists and evaluators. In particular, the management of event portfolios and policies covering events in cities and destinations can benefit from the documented method for explicitly balancing risks with perceived value. Social implications - A portfolio perspective is also suggested as an approach to analyse the total tourist attractions portfolio of a destination. Originality/value - Opinions regarding public value and risk by civil servants who work with events have not been studied before. The constant comparative method produces results that can be applied to policies governing events. In terms of theory development, concepts from financial portfolio management, product portfolio management and risk management are used to develop event portfolio design and management, and insights are gained on trade-offs in the process. The plot of the events in a two-dimensional chart of value versus risk clearly differentiated the 14 events and is an original contribution.
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| 7. |
- Andersson, Tommy D., 1947, et al.
(författare)
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Commensurability and sustainability: Triple impact assessments of a tourism event
- 2013
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Ingår i: Tourism Management. - : Elsevier BV. - 0261-5177 .- 1879-3193. ; 37, s. 99-109
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Tidskriftsartikel (refereegranskat)abstract
- In this study, a model for measuring impacts of a tourist event from sustainability perspectives and in a common monetary metric is developed. The aim is to achieve commensurability. The proposed model is tested on a three-day music festival and the results demonstrate a possibility to produce a sustainability impact analysis in a uniform metric. Measured in monetary terms, socio-cultural impacts carry weight just as economic impacts do whereas environmental impacts have little importance for the total assessment. This illustrates how the low market value of emission rights make environmental concerns negligible from an economic perspective. Finally, issues related to scope of the assessment, commensurability and opportunity cost are discussed and possibilities for future studies are suggested. (C) 2013 Elsevier Ltd. All rights reserved.
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| 8. |
- Andersson, Tommy D., 1947
(författare)
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Cost Analysis
- 2005
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Ingår i: International Encyclopedia of Hospitality Management /Abraham Pizam (ed. in chief), Elsevier Butterworth Heinemann. - 9780750659963
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 9. |
- Andersson, Tommy D., 1947, et al.
(författare)
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Estimating Use and Non-use Values of a Music Festival
- 2012
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Ingår i: Scandinavian Journal of Hospitality and Tourism. - : Informa UK Limited. - 1502-2250 .- 1502-2269. ; 12:3, s. 215-231
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Tidskriftsartikel (refereegranskat)abstract
- Impacts of a music festival may appear in many forms and research in the area of impact assessments is at present developing wider perspectives than being limited to economic impact assessments. Concepts like social, cultural and environmental impacts are now appropriate and traditional cost–benefit analysis is regaining momentum. The purpose of this study was first, to discuss how the value of a festival can be assessed and understood within a cost–benefit framework. Second, it was to evaluate a Scandinavian music festival in terms of Use and Non-use values by the contingent valuation method. The results illustrate the implications of a wider perspective regarding the impacts of a festival. Use value, representing the core experience, is the largest value (€7.4 million) but Non-use value is also important (€3 million). The latter includes the perceived value of externalities such as socio-cultural and environmental impacts which are highly relevant from a sustainability perspective. One conclusion is that Use and Non-use values within a cost–benefit framework can help managers and researchers understand value creation of festivals better.
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