| 1. |
- Andersson, Malou, 1973-
(author)
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Grov fridskränkning och grov kvinnofridskränkning : Fridskränkningsbrotten som rättslig konstruktion
- 2016
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Doctoral thesis (other academic/artistic)abstract
- Over the last decades men’s physical and psychological violence against women in intimate relationships (domestic violence) has become a central issue in Swedish politics. Men’s physical and psychological violence against women is generally be understood as including physical, sexual and psychological violence (e.g rape, battery, sexual abuse or insults) that occurs within the family, whether or not the perpetrator shares or has shared the same residence with the woman. Law reforms have been carried through with the objective of enhancing criminal legal protection for women. In 1999, a new law came into force within the framework of chapter 4 of the Penal Code which includes any member of the family with the objective to treat acts that are already criminal from a different perspective if they are committed within a pattern of systematic physical and psychological violence.This doctoral thesis examines the concept of domestic violence and the criminal act in Chapter 4, section 4 a of the Swedish Penal Code which prescribes liability for violation of integrity offences. According to the first paragraph, a person who commits criminal acts as defined in Chapters 3, 4, 6 or 12 or of the Swedish Penal Code (e.g. rape, battery, sexual abuse or insults) or violation of a restraining order against a person with whom they have or have previously had, a close relationship will be sentenced for gross violation of integrity to imprisonment for at least nine months and at most six years if each of the acts were part of a repeated violation of the person’s integrity and the acts were liable to severely damage the person’s self-esteem. The second paragraph states if the acts were committed by a man against a woman to whom he is, or has been married or with whom he is, or has been cohabiting under circumstances comparable to marriage. He will instead be sentenced for a gross violation of a woman’s integrity to the same punishment. The objective of introducing a violation of integrity offence was to enable criminal proceedings to take in to account the abused person’s entire situation when he or she has been subjected to a series of albeit punishable but often individually relatively minor acts and to bring about an upgrading of the penal value of such acts. The main purpose of this thesis is to examine when and under which circumstances a person can be held responsible for gross violation of integrity or gross violation of a woman’s integrity. The analysis aims at the construction of the law, but also to examine the legal and social consequences and the interpretation and application of the law.
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| 2. |
- Gunnarsson, Ulrika
(author)
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Genetic Studies of Pigmentation in Chicken
- 2009
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Doctoral thesis (other academic/artistic)abstract
- Domestic animals have been selected by humans for thousands of years, which have drastically altered their genetic constitution and phenotypes. In this thesis, several of the most important genes causing pigmentation differences between the wild red junglefowl (Gallus gallus) and domestic chickens have been identified. Pigmentation phenotypes are easily scored, and the genes underlying these phenotypes are valuable models to study gene function and gene interaction. Dominant white colour is widespread among domestic chickens. The Dominant white allele specifically inhibits the expression of black (eumelanin) pigment and we identified several insertion/deletion mutations in the PMEL17 gene causing the different phenotypes controlled by this locus. The Silver allele on the other hand inhibits the expression of red (pheomelanin) colour and is a genetic variant of the SLC45A2 gene. Silver is the first pheomelanin-specific mutation(s) reported for this gene. An 8 kb deletion, including a conserved enhancer element, 14 kb upstream of the transcription factor SOX10 is causing the Dark brown phenotype. This phenotype restricts the expression of eumelanin and enhances red pheomelanin in specific parts of the plumage. These three gene identifications have extended the knowledge about genes affecting melanocyte function. Carotenoid-based pigmentation is of utmost importance in birds and other animals. The yellow skin allele in chicken allows deposition of carotenoids in skin and explains why most domestic chickens have yellow legs. We demonstrated that the yellow skin phenotype is caused by a tissue specific regulatory mutation in the gene for the enzyme beta-caroten dioxygenase 2 (BCDO2). This was the first identification of a specific gene underlying carotenoid-based pigmentation. Interestingly, the yellow skin haplotype was shown to originate from the grey junglefowl (Gallus sonneratii) and not the red junglefowl as expected, thus presenting the first conclusive evidence for a hybrid origin of the domestic chicken.
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| 3. |
- Ahlstedt, Sara, 1977-
(author)
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The Feeling of Migration : Narratives of Queer Intimacies and Partner Migration
- 2016
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Doctoral thesis (other academic/artistic)abstract
- This dissertation analyzes narratives of queer partner migration, that is, a family-tie migration in which one of the partners of a relationship has migrated in order for the partners to be together, and where the partners queer the migration in the sense that they have a non-normative sexuality and/or gender identity. The purpose of the study is to examine how queer partner migrants and their Swedish partners experience the migration process – which continues also once the administrative process has been completed – by analyzing the emotions and feelings that emerge in the process. The study is a contribution to research on privileged migration as well as intimate migration.The focus is the queer partner migration relationship, and what emotions and feelings ‘do’ to this relationship, but also how emotions and feelings structure the migration process. The study analyzes the work three different emotions – love, loss, and belonging – do in these migration processes, and how this work is described in the participant narratives. Migrant participants have migrated from different parts of the world (Africa, Europe, Latin America, and North America), making it possible to analyze what emotions and feelings do in this particular migration process from the point of view of nationality and, in particular, proximity to ‘Western-ness,’ race, and language as well as how privileges connected to these positions come to matter in the process.The dissertation is an ethnographic interview study in which both migrants and Swedish partners have been interviewed. The interview material consists of a combination of couple interviews and individual interviews.By using affect theories and the concept of queer phenomenology, the dissertation shows how the work that emotions and feelings do in migration processes is connected to gender identity, sexual identity, race and whiteness, nationality, perceived proximity to Western-ness, class, language, and the migration narrative the migrating partner is (or is not) written into by way of the country they have migrated from. This is analyzed in relation to the theoretical frameworks of entanglement, homonationalism, and intimate citizenship.The analysis shows that emotions and feelings structure the migration process for both more privileged and less privileged migrants, but in different ways. The understanding of who ‘is’ a migrant, and the preparedness for the feelings that arise in a migration process, are tied to the positions mentioned above and the privileges these positions give, or do not give, the migrant access to. By focusing on emotions and feelings and what these do, the study also illustrates how the migration process affects the non-migrating partner as this partner engages in emotional labour to ‘make’ the migrating partner ‘Swedish.’ Through their the migrating partner, the non-migrating partner is also aligned in a way that makes them a little bit less ‘Swedish,’ contributing to the non-migrating partner being ‘stopped’ in ways they have usually not experienced before. The study further shows how migration processes produces inequality, and the difficulties that arise when the couples try to live up to the Swedish ideal of the equal relationship.The interviews are analyzed as narratives, and both narratives and storytelling are important throughout the dissertation, not only as the method used in the analysis but as the form of the dissertation, making it a kind of super structure organizing the writing. Writing (how to write accessibly and interesting) and reading (how to write in order to invite an open and active reading) are important aspects of the dissertation.
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| 4. |
- Andersson, Réka
(author)
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Gränsdragningar i Vårdens Vardag : Hanteringen av arbetsrelaterad psykisk ohälsa i det svenska välfärdssystemet
- 2017
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Doctoral thesis (other academic/artistic)abstract
- Psykisk ohälsa i arbetslivet är ett stort och växande problem i välfärdssamhället. Problemet har flera bottnar och väcker många frågor om vem som har ansvar, vad det egentligen är för ett slags fenomen och hur det bör hanteras. Den här studien undersöker hur arbetsrelaterad psykisk ohälsa hanteras av yrkesverksamma inom vården, med fokus på företagshälsovård och primärvård. Intresse riktas mot hur yrkesverksamma personerna resonerar kring arbetsrelaterad psykisk ohälsa, vilka dilemman de ställs inför och de strategier de har för att hantera dessa. Den söker också svar på ansvarsfrågan kring detta komplexa problem, inte minst i ljuset av privatiseringen av företagshälsovården.I studien används ett tvärvetenskapligt perspektiv, där begrepp från teknik- och vetenskapsstudier (STS), professionssociologi och organisationsteori kombineras för att analysera olika aspekter av vårdens hantering av arbetsrelaterad psykisk ohälsa. Det empiriska materialet bygger i huvudsak på intervjuer med läkare, psykoterapeuter, kuratorer, arbetsterapeuter, psykologer, rehabiliteringskoordinatorer och beteendevetare, men inkluderar även observationer inom primärvård och företagshälsovård. Hanteringen av arbetsrelaterad psykisk ohälsa i vårdens vardag präglas av att orsaksbilden till problemet är komplext, ansvarsfördelningen otydlig och att psykosociala orsaker till sjukdom är kontroversiellt. I studien diskuteras utmaningarna och möjligheterna kring hanteringen av detta komplexa problem i bred bemärkelse. I analyserna uppmärksammas de yrkesverksammas gränsdragningar kring både ansvar och fenomenet arbetsrelaterad psykisk ohälsa. Begreppet kunskapsinfrastruktur används för att förklara och förstå den kunskapsmässiga och materiella struktur som de yrkesverksamma verkar inom. Analyserna visar att de yrkesverksamma har ett pragmatiskt förhållningssätt och använder olika strategier för att skapa sig handlingsutrymme i hur de hanterar arbetsrelaterad psykisk ohälsa.
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| 5. |
- Andersson Trovalla, Ulrika, 1972-
(author)
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Medicine for Uncertain Futures : A Nigerian City in the Wake of a Crisis
- 2011
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Doctoral thesis (other academic/artistic)abstract
- The Nigerian city of Jos used to be seen as a peaceful place, but in 2001 it was struck by clashes that arose from what was largely understood as issues of ethnic and religious belonging. The event, which would become known as ‘the crisis’, was experienced as a rupture and a loss of what the city had once been, and as the starting point of a spiral of violence that has continued up to today. With the crisis, Jos changed. Former friends became enemies, and places that had been felt to be safe no longer were so. Previous truths were thrown into confusion, and Jos’s inhabitants found themselves more and more having to manoeuvre in an unstable world coloured by fear and anger. Life in Jos became increasingly hard to predict, and people searched for different ways forward, constantly trying out new interpretations of the world. This book, which is inspired by pragmatism, analyses the processes that were shaping the emergent city of Jos and its inhabitants in the aftermath of the crisis. At its core are some of Jos’s practitioners of traditional medicine. As healers, diviners, and providers of spells to protect from enemies or solve conflicts, they had special skills to influence futures that were becoming more and more unpredictable. Still, the medical practitioners were as vulnerable to the changing circumstances as everyone else. Their everyday lives and struggles to find their footing and ways forward under the changing circumstances are used as a point of departure to explore larger wholes: life during times characterised by feelings of uncertainty, fragmentation, fear, and conflict – in Jos as a city and Nigeria as a nation.
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| 6. |
- Andersson, Ulrika B., 1967-
(author)
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Framåtsyftande bedömning i tidig läsundervisning : Teori och praktik
- 2021
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Doctoral thesis (other academic/artistic)abstract
- Syfte är att bidra med kunskap om hur framåtsyftande bedömning kan användas och används av lärare som underlag för pedagogiska åtgärder i tidig läsundervisning. I avhandlingen har jag ett pragmatiskt förhållningssätt till både teorier och metoder. Avhandlingen bygger på fyra artiklar. Datainsamling gjordes genom artikelläsning (artikel I), fokusgruppsintervjuer (artikel Il) och narrativa intervjuer (artikel III) och testresultat (artikel IV). Resultaten analyserades med; Venn-diagram (I), tematisk analys (II), narrativ analys (lll) och variansanalys (IV). Resultaten visar att formativ bedömning och Response to intervention kan komplettera varandra och att kunskap om olika framåtsyftande förhållningssätt och teorier kan underlätta lärares professionella utveckling. Det framgår också att sociala bedömningsaspekter är viktiga i avkodningsundervisningen. Resultaten visar att en stor andel av eleverna i åk 1 har fortsatt behov av avkodningsträning även i slutet av åk 1. Bedömningsverktyg för läsundervisning behöver därför ge tydlig och återkommande information om elevens förmåga att avkoda. Resultaten visar att lärarnas användning av bedömningsverktyg påverkas av kontexten. Det handlar om att uppmärksamma specifika förutsättningar och att organisera bedömningspraktiken så att ett ömsesidigt och hållbart utbyte uppstår mellan läraren, eleven och bedömningsverktyget.
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| 7. |
- Andersson, Ulrika
(author)
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Beta-glucose 1-phosphate interconverting enzymes in Lactococcus lactis: physiological role and regulation in maltose, trehalose and glucose metabolism
- 2002
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Doctoral thesis (other academic/artistic)abstract
- Lactic acid bacteria (LAB), including Lactococcus lactis, are abundant in nature. These bacteria convert carbohydrates into mainly lactate by a rather uncomplicated metabolism. An improved understanding of the physiological and genetical mechanisms involved in carbohydrate metabolism and its regulation will improve the industrial use of LAB. The aim of this study was to investigate the maltose and trehalose assimilating pathways in L. lactis. The maltose phosphorylase (MP) and beta-phosphoglucomutase (b-PGM) of L. lactis were characterised and shown to constitute the major maltose-degrading pathway in this bacterium. Furthermore, MP and b-PGM were shown to be present in many other strains of LAB belonging to the low G+C content LAB of the clostridial sub-branch of gram-positive bacteria. The MP-encoding gene, malP, was localised in an operon distinctive from that of the gene encoding b-PGM, pgmB. In addition, malR, encoding the maltose operon regulator (MalR), was localised downstream of malP. The presence of MalR was shown to be crucial for the synthesis of an ATP-dependent maltose translocation system. However, MP and b-PGM activity were not affected by a disruption of the MalR-encoding gene. Instead, synthesis of b-PGM has been shown to be exposed to carbon catabolite repression, which was also shown to be the case for MP. pgmB is located in the putative trehalose operon including the genes presumed to code for the trehalose-specific components of the phosphotransferase system transporting trehalose into the cells. Furthermore, directly upstream of pgmB, trePP was localised. This gene was shown to encode a novel phosphorylase, trehalose 6-phosphate phosphorylase (TrePP), catalysing the reversible Pi-dependent phosphorolysis of trehalose 6-phosphate to beta-glucose 1-phosphate and glucose 6-phosphate. TrePP was biochemically characterised and shown to be present in a few other species, mainly Enterococcus faecalis, of low G+C content LAB. The role of b-PGM in trehalose metabolism and in polysaccharide synthesis was assessed by disrupting its encoding gene. b-PGM was shown to be crucial for trehalose assimilation in L. lactis, while the b-PGM-deficient strain continued to grow with a tenfold decreased growth rate on maltose, compared to the wild-type strain. The b-PGM-deficient strain showed an enhanced production of polysaccharide, composed of alpha-1,4-linked glucose units when cultivated on maltose. It was suggested that this polysaccharide was a result from another metabolic pathway, resembling the maltodextrin system in Escherichia coli. Global regulatory circuits play a notable role when cells are adapting to environmental changes. A L. lactis mutant, TMB5003, was obtained by an unknown genetic event in the wild-type strain 19435. TMB5003 possessed an enhanced growth rate in glucose batch culture and a 1.5 times higher specific lactate productivity under non-limiting glucose conditions, compared to 19435. TMB5003 transported glucose by a non-saturating mode and the lactate dehydrogenase activity was twenty times higher in this strain compared to 19435. In conclusion, the results obtained for TMB5003, together with the characterisation of the initial disaccharide metabolism in L. lactis, may lead to improved industrial lactate production from LAB.
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| 8. |
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| 9. |
- Andersson, Ulrika, 1963-
(author)
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Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family
- 2005
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Doctoral thesis (other academic/artistic)abstract
- Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. The aim of this thesis was to characterise factors in primary brain tumours associated with the development of resistance with focus on the epidermal growth factor receptor (ErbB) family, and multidrug resistance (MDR). Influences of irradiation on the expression and activity of P-glycoprotein (Pgp) in malignant gliomas was evaluated. The effects showed that irradiation increased the efflux activity of Pgp in rat brain vascular endothelial cells, but not in glioma cells. In the intracranial BT4C glioma model, Pgp was detected in the capillary endothelium in the tumour tissue but not in glioma cells. Expression of several factors coupled to MDR (Pgp, MRP1, LRP, and MGMT) in primary brain tumours were analysed and correlated to clinical data. In gliomas, Pgp and MRP1 were predominantly observed in capillary endothelium and in scattered tumour cells, whereas LRP occurred only in tumour cells. In meningiomas, expression of the analysed markers was demonstrated in the capillary endothelium, with a higher expression of Pgp and MRP1 in transitional compared to meningothelial meningiomas. A pronounced expression of MGMT was found independently of the histopathological grade or tumour type. Survival analysis indicated a shorter overall survival for patients suffering from low-grade gliomas with high expression of Pgp. To explore the importance of the epidermal growth factor receptor (EGFR), expression levels of the family members (EGFR, ErbB2-4) were analysed and their relations to various clinical parameters were evaluated in gliomas and meningiomas. In gliomas, the highest EGFR expression was observed in high-grade tumours, while ErbB4 expression was most pronounced in low-grade tumours. In meningiomas, expression of EGFR, ErbB2, and ErbB4 was observed in the majority of the tumours. An intriguing observation in low-grade gliomas was a significantly decreased overall survival for patients with high EGFR protein expression. The effects of different time schedules for administration of the selective EGFR inhibitor ZD1839 in relation to irradiation of glioma cells were analysed. The analyses showed a heterogeneity in the cytotoxic effects of ZD1839 between cell lines, and it was obvious that some of the cell lines showed sensitivity to ZD1839 despite no or low expression of EGFR. The study also demonstrated the importance of timing of ZD1839 administration when this agent is combined with irradiation. In conclusion, in order to enhance the efficacy of radiotherapy by various drugs in malignant gliomas it may be essential to inhibit drug efflux activity in endothelial cells and to deliver drugs in an optimal timing in relation to radiotherapy. The heterogeneity in expression of drug resistance markers, as well as the ErbB family reflects the complexity in classification of primary brain tumours, and indicates that subgroups of patients with low-grade gliomas expressing Pgp and EGFR might benefit from more aggressive and individualised treatment.
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| 10. |
- Andersson, Ulrika
(author)
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Hans (ord) eller hennes? : en könsteoretisk analys av straffrättsligt skydd mot sexuella övergrepp
- 2004
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Doctoral thesis (other academic/artistic)abstract
- The criminal justice system in modern western democracies is built on the rights of the one who is being accused of a crime, the subject of criminal responsibility, in relation to the repressive power held by the state. The entire system rests upon rules and principles, aiming at ensuring the rule of law as far as this subject is concerned. The subject is presumed to be autonomous and is set before the law according to the legal doctrine on criminal responsibility, presupposing that this subject makes free, rational choices. This thesis focuses the victim, or the one who may claim protection from a certain criminal provision: the subject of criminal protection. The main purpose is to explore and analyze the construction of this subject in criminal law in relation to sexual offences. The starting-point is that sex, as well as gender, is constructed, and that legal discourses contribute in doing so, while simultaneously producing the subjects set before the law. Drawing on the concept of discursive power put forward by Michel Foucault and Judith Butler’s constructivist theory of gender founded on the heterosexual matrix, the legal discourses are analyzed as such. The question is how these discourses construct, or produce the subject of criminal protection, more specifically regarding to body, sexuality and gender. It is argued that these discourses produce a subject with an open, accessible body and an accessible, passive sexuality, in other words a subject which is clearly feminine.
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