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Evaluation of new s...
Evaluation of new sclerotic bone metastases in breast cancer patients during treatment
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- Ciray, Ipek (författare)
- Uppsala universitet,Enheten för radiologi
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- Åström, Gunnar (författare)
- Uppsala universitet,Enheten för radiologi
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- Andréasson, I (författare)
- Uppsala universitet,Enheten för onkologi
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visa fler...
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Edekling, T (författare)
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Hansen, J (författare)
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- Bergh, J (författare)
- Uppsala universitet,Enheten för onkologi
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi
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visa färre...
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(creator_code:org_t)
- 2000
- 2000
- Engelska.
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Ingår i: Acta Radiologica. - 0284-1851 .- 1600-0455. ; 41:2, s. 178-182
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- PURPOSE: According to the World Health Organization (WHO) criteria for response of bone metastases to therapy, new lesions indicate progressive disease. We intended to prove that a new sclerotic lesion on conventional radiography may also be a sign of a positive therapeutic response in a previously undetectable lytic metastasis. MATERIAL AND METHODS: In a previous placebo-controlled clinical trial of clodronate (Ostac) therapy, 139 breast cancer patients with bone metastases underwent both conventional radiography and bone scan every 6 months for 2 years with 99mTc before and during clodronate treatment. WHO criteria were applied for therapy response evaluation. RESULTS: In 24 patients, 52 new sclerotic lesions observed during therapy were selected for re-evaluation of conventional radiographs and bone scans. In 8 of the 24 patients, 17 of 52 new sclerotic lesions (33%) had showed positive uptake on previous bone scans. These lesions were possibly misinterpreted as new when applying WHO criteria. CONCLUSION: For better assessment of new sclerotic lesions during treatment, more sensitive techniques, e.g. bone scan, are needed as a complement to conventional radiography.
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- art (ämneskategori)
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