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| 2. |
- Kurilshikov, Alexander, et al.
(författare)
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Large-scale association analyses identify host factors influencing human gut microbiome composition
- 2021
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 53:2, s. 156-165
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Tidskriftsartikel (refereegranskat)abstract
- To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 x 10(-8)) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 x 10(-20)), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 x 10(-10) < P < 5 x 10(-8)) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis.
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| 3. |
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| 4. |
- Andreasson, Joakim, 1973, et al.
(författare)
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A simplicity-guided approach toward molecular set-reset memories
- 2010
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Ingår i: New Journal of Chemistry. - : Royal Society of Chemistry (RSC). - 1369-9261 .- 1144-0546. ; 34:12, s. 2701-2703
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Tidskriftsartikel (refereegranskat)abstract
- Photochromic switches fulfill the general molecular design criteria for the surprisingly straightforward small-scale integration of seemingly complex set-reset latches. The implications of this re-interpretation are discussed with the example of a dithienylethene photochrome. The concept is shown to be valid for a multitude of well-introduced bistable switches with clearly differentiated output signals, e.g., optical signals for the presented example.
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| 5. |
- Andreasson, Joakim, 1973, et al.
(författare)
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All-Photonic Multifunctional Molecular Logic Device
- 2011
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 133:30, s. 11641-11648
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Tidskriftsartikel (refereegranskat)abstract
- Photochromes are photoswitchable, bistable chromophores which, like transistors, can implement binary logic operations. When several photochromes are combined in one molecule, interactions between them such as energy and electron transfer allow design of simple Boolean logic gates and more complex logic devices with all-photonic inputs and outputs. Selective isomerization of individual photochromes can be achieved using light of different wavelengths, and logic outputs can employ absorption and emission properties at different wavelengths, thus allowing a single molecular species to perform several different functions, even simultaneously. Here, we report a molecule consisting of three linked photochromes that can be configured as AND, XOR, INH, half-adder, half-subtractor, multiplexer, demultiplexer, encoder, decoder, keypad lock, and logically reversible transfer gate logic devices, all with a common initial state. The system demonstrates the advantages of light-responsive molecules as multifunctional, reconfigurable nanoscale logic devices that represent an approach to true molecular information processing units.
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| 6. |
- Andreasson, Joakim, 1973, et al.
(författare)
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Molecules with a sense of logic: a progress report
- 2015
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Ingår i: Chemical Society Reviews. - 1460-4744 .- 0306-0012. ; 44:5, s. 1053-1069
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Forskningsöversikt (refereegranskat)abstract
- In this tutorial review, the most recent developments in the field of molecular logic and information processing are discussed. Special emphasis is given to the report of progress in the concatenation of molecular logic devices and switches, the design of memory systems working according to the principles of sequential logic, the mimicking of transistors, and the research on photochromic platforms with an unprecedented degree of functional integration. Furthermore, a series of achievements that add up to the conceptual diversity of molecular logic is introduced, such as the realization of highly complex and logically reversible Toffoli and Fredkin gates by the action of DNAzymes or the use of a multifluorophoric platform as a viable approach towards keypad lock functions.
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| 7. |
- Andreasson, Joakim, 1973, et al.
(författare)
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Smart molecules at work-mimicking advanced logic operations
- 2010
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Ingår i: Chemical Society Reviews. - : Royal Society of Chemistry (RSC). - 1460-4744 .- 0306-0012. ; 39:1, s. 174-188
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Tidskriftsartikel (refereegranskat)abstract
- Molecular logic is an interdisciplinary research field, which has captured worldwide interest. This tutorial review gives a brief introduction into molecular logic and Boolean algebra. This serves as the basis for a discussion of the state-of-the-art and future challenges in the field. Representative examples from the most recent literature including adders/subtractors, multiplexers/demultiplexers, encoders/decoders, and sequential logic devices (keypad locks) are highlighted. Other horizons, such as the utility of molecular logic in bio-related applications, are discussed as well.
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| 8. |
- Budelmann, D., et al.
(författare)
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Antiferromagnetic and superconducting proximity effects in YBa2Cu3O7-delta/PrBa2Cu3O7-delta superlattices
- 2003
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Ingår i: Physical Review B Condensed Matter. - 0163-1829 .- 1095-3795. ; 67, s. 140507-
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Tidskriftsartikel (refereegranskat)abstract
- We investigate the interplay between the antiferromagnetic and superconducting order parameters in YBa2Cu3O7-delta/PrBa2Cu3O7-delta superlattices by inelastic light scattering. The ratio of superconducting to antiferromagnetic order is varied through different modulations 4/6, 4/9, and 4/12 of (Y/Pr)Ba2Cu3O7-delta layers. This allows us to identify the proximity effect of the superconducting order parameter into the antiferromagnetic barrier as signified, e.g., by the sharpening of the two-magnon excitation. This proximity effect as well as gap feature and phonon anomalies reveals the delicate interplay between superconducting and antiferromagnetic order parameters.
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| 9. |
- Gust, D., et al.
(författare)
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Data and signal processing using photochromic molecules
- 2012
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Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1364-548X .- 1359-7345. ; 48:14, s. 1947-1957
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Tidskriftsartikel (refereegranskat)abstract
- Photochromes are chromophores that are reversibly isomerized between two metastable forms using light, or light and heat. When photochromes are covalently linked to other chromophores, they can act as molecular photonic analogues of electronic transistors. As bistable switches, they can be incorporated into the design of molecules capable of binary arithmetic and both combinatorial and sequential digital logic operations. Small ensembles of such molecules can perform analogue signal modulation similar to that carried out by transistor amplifiers. Examples of molecules that perform multiple logic functions, act as control elements for fluorescent reporters, and mimic natural photoregulatory functions are presented.
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| 10. |
- Nilsson, Jesper, 1984, et al.
(författare)
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Switching Properties of a Spiropyran-Cucurbit [7] uril Supramolecular Assembly: Usefulness of the Anchor Approach
- 2012
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Ingår i: ChemPhysChem. - : Wiley. - 1439-7641 .- 1439-4235. ; 13:16, s. 3691-3699
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Tidskriftsartikel (refereegranskat)abstract
- A nitrospiropyran, which was modified with a cadaverine-derived anchor, was investigated with respect to its thermally induced isomerizations, hydrolytic stability of the merocyanine form, and photochromic ring closure. The hostguest complexation of the anchor by the cucurbit[7]uril macrocycle, evidenced by absorption titration, NMR spectroscopy, and electrospray ionization mass spectrometry, produced significant improvements of the switching properties of the photochrome: 1) appearance of the merocyanine form about 70 times faster, 2) practically unlimited hydrolytic stability of the merocyanine (two and a half days without any measureable decay), and 3) fast, clean, and fatigue-resistant photoinduced ring closure back to the spiro form. The importance of an adequate molecular design of the anchor was demonstrated by including control experiments with spiropyrans with a shorter linker or without such structural asset.
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