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Sökning: WFRF:(Appleton R)

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  • Arendt, Josephine, et al. (författare)
  • Clinical update : melatonin and sleep disorders.
  • 2008
  • Ingår i: Clin Med. - 1470-2118. ; 8:4, s. 381-3
  • Tidskriftsartikel (refereegranskat)abstract
    • Clinical update: melatonin and sleep disorders.Arendt J, Van Someren EJ, Appleton R, Skene DJ, Akerstedt T.Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford. j.arendt@surrey.ac.ukThe hormone melatonin is increasingly used for the treatment of certain sleep disorders, particularly those related to disturbed biological rhythms. This article summarises current knowledge of its mechanism of action and identifies situations where there is good evidence for its efficacy. The authors provide advice, based on their own experience and consistent published data, concerning the dose range of melatonin to be used and the critically important question of the timing of treatment. Anecdotal evidence for the use of melatonin needs to be replaced by data from well-controlled, preferably multi-centre, randomised clinical trials.
  • Xu, C. K., et al. (författare)
  • ALMA observationsof warm dense gas in NGC 1614-breaking of the star formation law in the central kiloparsec
  • 2015
  • Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 799:1
  • Tidskriftsartikel (refereegranskat)abstract
    • We present ALMA Cycle-0 observations of the CO (6-5) line emission and of the 435 mu m dust continuum emission in the central kiloparsec of NGC 1614, a local luminous infrared galaxy at a distance of 67.8 Mpc (1 '' = 329 pc). The CO emission is well resolved by the ALMA beam (0.'' 26x0.'' 20) into a circumnuclear ring, with an integrated flux of f(C O(6-5)) = 898 (+/- 153) Jy km s(-1), which is 63(+/- 12)% of the total CO (6-5) flux measured by Herschel. The molecular ring, located between 100 pc
  • Appleton, Jason Philip, et al. (författare)
  • The TOS2 study: An international multi-centre audit assessing the standard of neurological examination
  • 2015
  • Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ Publishing Group. - 1468-330X. ; 86:11
  • Konferensbidrag (refereegranskat)abstract
    • Having previously demonstrated that in-patients referred to neurology at two UK hospitals were not fully examined prior to referral, we designed an audit with 80% power to detect a 10% increase in tendon hammer or ophthalmoscope use following an educational intervention. In-patients referred to neurology over a 4 month period in the UK, Jordan, Sweden and the United Arab Emirates were asked whether they recalled examination with a Tendon hammer, Ophthalmoscope and Stethoscope since admission. Results were disseminated to local medical teams and data were collected for a further 4 months. Pre and post-intervention data were available for 11 centres with 407 and 391 patients in each arm. 264 patients (64.86%) recalled examination with a tendon hammer preintervention, which significantly improved to 298 (76.21%) (p
  • Parra Barraza, Rodrigo, 1974, et al. (författare)
  • 2010
  • Ingår i: Astrophysical Journal. - 1538-4357 .- 0004-637X. ; 720:1, s. 555-568
  • Tidskriftsartikel (refereegranskat)abstract
    • We present results from 4.8 GHz Very Large Array (VLA) and global very long baseline interferometry (VLBI) observations of the northern half of the moderate FIR luminosity (median L-IR = 10(11.01) L-circle dot) COLA sample of star-forming galaxies. VLBI sources are detected in a high fraction (20/90) of the galaxies observed. The radio luminosities of these cores (similar to 10(21) W Hz(-1)) are too large to be explained by radio supernovae or supernova remnants and we argue that they are instead powered by active galactic nuclei (AGNs). These sub-parsec scale radio cores are preferentially detected toward galaxies whose VLA maps show bright 100-500 parsec scale nuclear radio components. Since these latter structures tightly follow the FIR to radio-continuum correlation for star formation, we conclude that the AGN-powered VLBI sources are associated with compact nuclear starburst environments. The implications for possible starburst-AGN connections are discussed. The detected VLBI sources have a relatively narrow range of radio luminosity consistent with models in which intense compact Eddington-limited starbursts regulate the gas supply onto a central supermassive black hole. The high incidence of AGN radio cores in compact starbursts suggests little or no delay between the starburst phase and the onset of AGN activity.
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