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MicroRNA Expression...
MicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer
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- Meng, Wen-Jian (författare)
- Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China,Sichuan University, Peoples R China
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- Yang, Lie (författare)
- Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China,Sichuan University, Peoples R China
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- Ma, Qin (författare)
- Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China,Sichuan University, Peoples R China
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- Zhang, Hong, 1957- (författare)
- Örebro universitet,Institutionen för läkarutbildning,University of Örebro, Sweden,Sichuan University, Peoples R China; Sichuan University, Peoples R China; Sichuan University, Peoples R China
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- Adell, Gunnar (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Arbman, Gunnar (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken ViN
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- Wang, Zi-Qiang (författare)
- Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China,Sichuan University, Peoples R China
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- Li, Yuan (författare)
- State Key Lab Biotherapy, Inst Digest Surg, West China Hosp, Sichuan Univ, Chengdu, Peoples R China; Ctr Canc, West China Hosp, Sichuan Univ, Chengdu, Peoples R China,Sichuan University, Peoples R China; Sichuan University, Peoples R China
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- Zhou, Zong-Guang (författare)
- Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China; State Key Lab Biotherapy, Inst Digest Surg, West China Hosp, Sichuan Univ, Chengdu, Peoples R China; Ctr Canc, West China Hosp, Sichuan Univ, Chengdu, Peoples R China
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- Sun, Xiao-Feng (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Sichuan University, Peoples R China; Sichuan University, Peoples R China
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2015
- 2015
- Engelska.
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Ingår i: Medicine. - : Lippincott Williams & Wilkins. - 0025-7974 .- 1536-5964. ; 94:32
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The expression of abnormal microRNA (miRNA, miR) is a ubiquitous feature of colorectal cancer (CRC). The pathological features and clinical behaviors of synchronous CRC have been comprehensively described; however, the expression profile of miRNA and small nucleolar RNA (snoRNA) in synchronous CRC has not been elucidated. In the present study, the expression profile of miRNA and snoRNA in 5 synchronous CRCs, along with the matched normal colorectal tissue was evaluated by microarray. Function and pathway analyses of putative targets, predicted from miRNA-mRNA interaction, were performed. Moreover, we analyzed clinicopathological and molecular characteristics of 22 patients with synchronous CRC and 579 solitary CRCs in a retrospective cohort study. We found a global dysregulation of miRNAs, including an oncogenic miR-17-92 cluster and oncosuppressive miR-143-145 cluster, and snoRNAs in synchronous CRC. Differential miRNA rather than snoRNA expression was robust enough to distinguish synchronous cancer from normal mucosa. Function analysis of putative targets suggested that miRNA clusters may modulate multiple effectors of oncogenic pathways involved in the pathogenesis of synchronous CRC. A comparison of normal mucosa between synchronous and solitary CRC suggested a differential genetic background of synchronous CRC from solitary CRC during carcinogenesis. Compared with solitary cancer patients, synchronous cases exhibited multiple extra-colonic cancers (P=0.012), coexistence of adenoma (P=0.012), microsatellite instability (P=0.024), and less glucose transporter 1 (P=0.037). Aberrant miRNA expression profiles could potentially be used as a diagnostic tool for synchronous CRC. Our findings represent the first comprehensive miRNA and snoRNA expression signatures for synchronous CRC, implicating that the miRNAs and snoRNAs may present therapeutic targets for synchronous CRC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Family Medicine
- Allmänmedicin
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Medicine
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- Av författaren/redakt...
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Meng, Wen-Jian
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Yang, Lie
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Ma, Qin
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Zhang, Hong, 195 ...
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Adell, Gunnar
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Arbman, Gunnar
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Wang, Zi-Qiang
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Li, Yuan
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Zhou, Zong-Guang
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Sun, Xiao-Feng
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Medicine
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Örebro universitet
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