| 1. |
- Archer, Trevor, 1949, et al.
(författare)
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Epigenetics in neuropsychiatry
- 2011
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Ingår i: Omics : Biomedical Perspectives and Applications / edited by Debmalya Barh, Kenneth Blum, Margaret A. Madigan. - : CRC Press. - 9781439850084 ; , s. 511-532
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The notion of epigenetics offers a putative interface between genetic and environmental factors that interact to provide the phenotypic. The impact of the environment on gene expression (epigenetics) and the convergence of genes and environment along common biological pathways induce greater effects than either those of genes or environment in isolation. Transgenerational epigenetic inheritance, i.e. the survival of epigenetic modifications over generations, provides a process through maternal nurturing behavior may affect the development and health of the offspring. Epigenetic operations regulate depressive disorders and schizophrenia spectrum disorders as well as interventional strategies. The present account examines epigenetic influences to inherited characteristics subjected to conditions of prenatal or early-life adversity that produce the eventual expressions of these disorders, and such developmental disorders as Prader-Willi syndrome. The essential role of nutrition is central: epigenetic regulation encompasses alterations of genetic material that do not affect the DNA nucleotide sequence, but rather include DNA methylation patterns, chromatin structure, histone codes, and noncoding small RNAs. Influences such as epigenetic interactions on DNA damage response and DNA repair may yet provide insights facilitating diagnosis and understanding of progression and intervention
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| 2. |
- Blum, K., et al.
(författare)
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Neuroquantum Theories of Psychiatric Genetics: Can Physical Forces Induce Epigenetic Influence on Future Genomes?
- 2015
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Ingår i: Neuroquantology. - 1303-5150. ; 13:1, s. 90-103
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Tidskriftsartikel (refereegranskat)abstract
- This paper serves to encourage quantum physicists to engage in psychiatric based research on the brain and its functions (i.e., consciousness, memory, attention). By using physics theorems such as Einstein's theory of relativity and the string theory, both physicists and geneticists alike may be able to elucidate potential links between components of the universe and their effects on the human brain. We have outlined some interesting posits including the cosmos' role in evolutionary biology, alpha bonding in biological molecules, and environmentally induced epigenetic effects on genetics. We also explore how physical forces can influence human memory, behavioral traits, and rates of addiction. Impulsiveness is used to exemplify how environmental changes can contribute to epigenetics and its hereditary alterations. We propose the idea of the presence of a "mental universe," where brain functionality like consciousness is a continuum of physically altered pathways. The realization that the universe and all of its precepts remains a mystery is reflected in the lack of a standardized "unified" physics theorem and mathematical equation that can explain universal dimensions (physical and mental), and as such, so is the complex nature of the functionality of the human brain. We provide herein a suggestion to remedy possible confusion, whereby we attempt to show the relationship of brain as a complex quantum-like organ and the impact of epigenetics on behavioral expression.
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| 3. |
- Blum, K., et al.
(författare)
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Substance use disorder a bio-directional subset of reward deficiency syndrome
- 2017
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Ingår i: Frontiers in Bioscience-Landmark. - : IMR Press. - 1093-9946 .- 1093-4715. ; 22, s. 1534-1548
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Tidskriftsartikel (refereegranskat)abstract
- This commentary is to inform clinicians challenged with an increase in people seeking treatment for Substance Use Disorder (SUD), that the ninety percent revolving door, is, in part, due to post-withdrawal, untreated neurotoxicity. This impairment attenuates neurotransmitter signaling and compromises resting state functional connectivity, leading to unwanted sequelae including depression, sleep disturbances, sensation seeking, lack of satisfaction and impulsivity. Neuroimaging studies indicate that neurobiological recovery can take years. Like a "double edge sword" SUD has a biological bi-directional (bio-directional) effect on the brain reward circuitry. The acute intake of psychoactive drugs results in heightened dopaminergic activity, while, the opposite, hypodopaminergia occurs following chronic abuse. Individuals with SUD can have a genetic predisposition, compounded by stress and neurotoxically induced, epigenetic insults that impact recovery from protracted abstinence. Follow-up post -short-term recovery usually includes supportive therapies and programs like 12 -steps and other fellowships. However, relapse will usually occur if post -short-term recovery hypodopaminergia is not treated with attempts at epigenetic manipulation of compromised brain neurochemistry using some manner of pro-dopamine regulation.
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