Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: WFRF:(Armand Philippe) > Sureda Anna > Reduced-intensity t...

1 of 1
Previous record
Next record
To hitlist

Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors

Kanate, Abraham S. (author): W Virginia Univ, Osborn Hematopoiet Malignancy & Transplantat Prog, Morgantown, WV 26506 USA.

Mussetti, Alberto (author): Ist Nazl Tumori, Fdn Ist Ricovero & Cura Carattere Sci, SC Ematol & Trapianto Midollo Osseo, Via Venezian 1, I-20133 Milan, Italy.

Kharfan-Dabaja, Mohamed A. (author): H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.

Ahn, Kwang W. (author): Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.

DiGilio, Alyssa (author): Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.

Beitinjaneh, Amer (author): Emily Couric Clin Canc Ctr, Div Hematol Oncol, Dept Med, Charlottesville, VA USA.

Chhabra, Saurabh (author): Med Univ S Carolina, Div Hematol Oncol, Charleston, SC 29425 USA.

Fenske, Timothy S. (author): Med Coll Wisconsin, Froedtert Mem Lutheran Hosp, Dept Hematol Oncol, Milwaukee, WI 53226 USA.

Freytes, Cesar (author): South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA.;Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.

Gale, Robert Peter (author): Univ London Imperial Coll Sci Technol & Med, Dept Med, Hematol Res Ctr, Div Expt Med, London, England.

Ganguly, Siddhartha (author): Univ Kansas, Med Ctr, Blood & Marrow Transplantat, Div Hematol & Oncol, Kansas City, KS 66103 USA.

Hertzberg, Mark (author): Prince Wales Hosp, Dept Haematol, Randwick, NSW 2031, Australia.

Klyuchnikov, Evgeny (author): Univ Canc Ctr, Dept Stem Cell Transplantat, Hamburg, Germany.

Lazarus, Hillard M. (author): Univ Hosp, Case Med Ctr, Seidman Canc Ctr, Cleveland, OH USA.

Olsson, Richard (author): Karolinska Institutet,Uppsala universitet,Hematologi,Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.

Perales, Miguel-Angel (author): Mem Sloan Kettering Canc Ctr, Adult Marrow Transplantat Serv, Dept Med, 1275 York Ave, New York, NY 10021 USA.

Rezvani, Andrew (author): Stanford Univ, Med Ctr, Blood & Marrow Transplantat, Stanford, CA 94305 USA.

Riches, Marcie (author): Univ N Carolina, Div Hematol Oncol, Chapel Hill, NC USA.

Saad, Ayman (author): Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL 35294 USA.

Slavin, Shimon (author): Int Ctr Cell Therapy & Canc Immunotherapy, Tel Aviv, Israel.

Smith, Sonali M. (author): Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USA.

Sureda, Anna (author): Hosp Duran I Reynals, Inst Catala Oncol, Serv Hematol, Barcelona, Spain.

Yared, Jean (author): Univ Maryland, Greenebaum Canc Ctr, Blood & Marrow Transplantat Program, Div Hematol Oncol,Dept Med, Baltimore, MD 21201 USA.

Ciurea, Stefan (author): Univ Texas Houston, MD Anderson Canc Ctr, Dept Hematol, 1515 Holcombe Blvd, Houston, TX 77030 USA.

Armand, Philippe (author): Dana Farber Canc Inst, Dept Med Oncol Hematol Malignancies, Boston, MA 02115 USA.

Salit, Rachel (author): Fred Hutchinson Canc Res Ctr, Dept Hematol Oncol, 1124 Columbia St, Seattle, WA 98104 USA.

Bolanos-Meade, Javier (author): Johns Hopkins Univ, Sidney Kimmel Canc Ctr, Div Hematol Malignancies, Baltimore, MD USA.

Hamadani, Mehdi (author): Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.

show less...

W Virginia Univ, Osborn Hematopoiet Malignancy & Transplantat Prog, Morgantown, WV 26506 USA Ist Nazl Tumori, Fdn Ist Ricovero & Cura Carattere Sci, SC Ematol & Trapianto Midollo Osseo, Via Venezian 1, I-20133 Milan, Italy. (creator_code:org_t)

American Society of Hematology, 2016
2016
English.
In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 127:7, s. 938-947

Related links:: https://ashpublicati...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

We evaluated 917 adult lymphoma patients who received haploidentical (n = 185) or HLA-matched unrelated donor (URD) transplantation either with (n = 241) or without antithymocyte globulin (ATG; n = 491) following reduced-intensity conditioning regimens. Haploidentical recipients received posttransplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis, whereas URD recipients received calcineurin inhibitor-based prophylaxis. Median follow-up of survivors was 3 years. The 100-day cumulative incidence of grade III-IV acute GVHD on univariate analysis was 8%, 12%, and 17% in the haploidentical, URD without ATG, and URD with ATG groups, respectively (P = .44). Corresponding 1-year rates of chronic GVHD on univariate analysis were 13%, 51%, and 33%, respectively (P < .001). On multivariate analysis, grade III-IV acute GVHD was higher in URD without ATG (P = .001), as well as URD with ATG (P = .01), relative to haploidentical transplants. Similarly, relative to haploidentical transplants, risk of chronic GVHD was higher in URD without ATG and URD with ATG (P < .0001). Cumulative incidence of relapse/progression at 3 years was 36%, 28%, and 36% in the haploidentical, URD without ATG, and URD with ATG groups, respectively (P = .07). Corresponding 3-year overall survival (OS) was 60%, 62%, and 50% in the 3 groups, respectively, with multivariate analysis showing no survival difference between URD without ATG (P = .21) or URD with ATG (P = .16), relative to haploidentical transplants. Multivariate analysis showed no difference between the 3 groups in terms of nonrelapse mortality (NRM), relapse/progression, and progression-free survival (PFS). These data suggest that reduced-intensity conditioning haploidentical transplantation with posttransplant cyclophosphamide does not compromise early survival outcomes compared with matched URD transplantation, and is associated with significantly reduced risk of chronic GVHD.

Find in a library

Blood (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

Articles in the publication: Blood

By the university: Uppsala University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors

Subject headings

Publication and Content Type

Find in a library

To the university's database

Find more in SwePub

Search outside SwePub