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Associations betwee...
Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction
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- Helseth, Ragnhild (författare)
- Oslo Univ Hosp Ulleval, Ctr Clin Heart Res, Dept Cardiol, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
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- Weiss, Thomas W. (författare)
- Wilhelminen Hosp, Dept Cardiol & Intens Care Med, Vienna, Austria.
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- Opstad, Trine Baur (författare)
- Oslo Univ Hosp Ulleval, Ctr Clin Heart Res, Dept Cardiol, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
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- Siegbahn, Agneta (författare)
- Uppsala universitet,Koagulation och inflammationsvetenskap
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- Solheim, Svein (författare)
- Oslo Univ Hosp Ulleval, Ctr Clin Heart Res, Dept Cardiol, N-0424 Oslo, Norway.
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- Freynhofer, Matthias K. (författare)
- Wilhelminen Hosp, Dept Cardiol & Intens Care Med, Vienna, Austria.
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- Huber, Kurt (författare)
- Wilhelminen Hosp, Dept Cardiol & Intens Care Med, Vienna, Austria.
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- Arnesen, Harald (författare)
- Oslo Univ Hosp Ulleval, Ctr Clin Heart Res, Dept Cardiol, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
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- Seljeflot, Seljeflot (författare)
- Oslo Univ Hosp Ulleval, Ctr Clin Heart Res, Dept Cardiol, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
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Oslo Univ Hosp Ulleval, Ctr Clin Heart Res, Dept Cardiol, N-0424 Oslo, Norway;Univ Oslo, Fac Med, Oslo, Norway. Wilhelminen Hosp, Dept Cardiol & Intens Care Med, Vienna, Austria. (creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
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Ingår i: Thrombosis Research. - : Elsevier BV. - 0049-3848 .- 1879-2472. ; 136:6, s. 1240-1244
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Several genes are expressed in aspirated coronary thrombi in acute myocardial infarction (AMI), exhibiting dynamic changes along ischemic time. Whether soluble biomarkers reflect the local gene environment and ischemic time is unclear. We explored whether circulating biomarkers were associated with corresponding coronary thrombi genes and total ischemic time. Material and methods: In 33 AMI patients undergoing percutaneous coronary intervention (PCI), blood samples were collected within 6-24 h for markers related to plaque rupture (metalloproteinase 9, tissue inhibitor of metalloproteinases 1), platelet and endothelial cell activation (P-selectin, CD40 ligand, PAR-1), hemostasis (tissue factor, tissue plasminogen activator, plasminogen activator inhibitor 1, free and total tissue factor pathway inhibitor, D-dimer, prothrombin fragment 1 + 2), inflammation (interleukin 8 and 18, fractalkine, monocyte chemoattractant protein 1 (MCP-1), CXCL1, pentraxin 3, myeloperoxidase) and galectin 3, caspase 8 and epidermal growth factor (EGF). Laboratory analyses were performed by Proximity Extension Assay (Proseek Multiplex CVD I-96 (x 96)), ELISAs and RT-PCR. Results: Only circulating P-selectin correlated to the corresponding P-selectin gene expression in thrombi (r = 0.530, p = 0.002). Plasma galectin 3, fractalkine, MCP-1 and caspase 8 correlated inversely to ischemic time (r = -0.38-0.50, all p < 0.05), while plasma MCP-1, galectin 3 and EGF were higher at short (<= 4 h) vs. long (>4 h) ischemic time (all p < 0.05). Conclusions: The dynamic changes in circulating mediators along ischemic time were not reflected in the profile of locally expressed genes. These observations indicate a locally confined milieu within the site of atherothrombosis, which may be important for selective therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Acute myocardial infarction
- Coronary artery disease
- Thrombus
- Gene expression
- Biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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