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1.	Niemi, MEK, et al. (author) 2021 swepub:Mat__t
2.	Ahmad, T, et al. (author) Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries 2016 In: British journal of anaesthesia. - : Elsevier BV. - 1471-6771 .- 0007-0912. ; 117:5, s. 601- Journal article (peer-reviewed)
3.	Ahmad, T, et al. (author) In-hospital clinical outcomes after upper gastrointestinal surgery: Data from an international observational study 2017 In: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. - : Elsevier BV. - 1532-2157 .- 0748-7983. ; 43:12, s. 2324-2332 Journal article (peer-reviewed)
4.	Ahmad, T, et al. (author) Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery 2017 In: British journal of anaesthesia. - : Elsevier BV. - 1471-6771 .- 0007-0912. ; 119:2, s. 258-266 Journal article (peer-reviewed)
5.	Adam, J, et al. (author) Measurement of D-s(+) product ion and nuclear modification factor in Pb-Pb collisions at root S-NN=2.76 TeV 2016 In: JOURNAL OF HIGH ENERGY PHYSICS. - : Springer. - 1029-8479. ; :3 Journal article (other academic/artistic)
6.	Zhou, XP, et al. (author) Non-coding variability at the APOE locus contributes to the Alzheimer's risk 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 3310- Journal article (peer-reviewed)abstract Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk factor in the APOE locus, it does not fully explain the risk effect conferred by the locus. Here, we report the identification of AD causal variants in PVRL2 and APOC1 regions in proximity to APOE and define common risk haplotypes independent of APOE-ε4 coding change. These risk haplotypes are associated with changes of AD-related endophenotypes including cognitive performance, and altered expression of APOE and its nearby genes in the human brain and blood. High-throughput genome-wide chromosome conformation capture analysis further supports the roles of these risk haplotypes in modulating chromatin states and gene expression in the brain. Our findings provide compelling evidence for additional risk factors in the APOE locus that contribute to AD pathogenesis.
7.	Phelan, CM, et al. (author) Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:5, s. 680-691 Journal article (peer-reviewed)
8.	Bojesen, SE, et al. (author) Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer 2013 In: Nature genetics. - New york : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:4, s. 371-384 Journal article (peer-reviewed)
9.	Wang, Li-San, et al. (author) Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States. 2015 In: JAMA neurology. - : American Medical Association (AMA). - 2168-6157 .- 2168-6149. ; 72:2 Journal article (peer-reviewed)abstract Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.
10.	Postmus, Iris, et al. (author) Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. 2014 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5 Journal article (peer-reviewed)abstract Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.

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Type of publication: journal article (45)

Type of content: peer-reviewed (44); other academic/artistic (1)

Author/Editor: Bojesen, Stig E. (13); Johansson, Mattias (12); Wichmann, H. Erich (12); Brennan, Paul (12); Johansson, Mikael (12); Kiemeney, Lambertus ... (12); show more...; Hung, Rayjean J. (12); Le Marchand, Loïc (11); Amos, Christopher I. (11); Risch, Angela (11); Aldrich, Melinda C (11); Chen, Chu (11); Christiani, David C. (11); Field, John K. (11); Lam, Stephen (11); Lazarus, Philip (11); Liu, Geoffrey (11); Schabath, Matthew B. (11); Tardon, Adonina (11); Melander, Olle (10); Grankvist, Kjell (10); Rennert, Gad (10); Cox, Angela (10); Manjer, Jonas (7); Han, Younghun (7); Brunnström, Hans (7); Landi, Maria Teresa (7); Bosse, Yohan (7); Kim, S. (6); Neuhausen, Susan L (6); Campbell, Harry (6); Taylor, Fiona (6); Carreras-Torres, Rob ... (6); Chenevix-Trench, Geo ... (6); Lissowska, Jolanta (6); Offit, Kenneth (6); Easton, Douglas F. (6); Ridker, Paul M. (6); Chasman, Daniel I. (6); Mangino, Massimo (6); Boomsma, Dorret I. (6); Harris, Tamara B (6); Hofman, Albert (6); Hayward, Caroline (6); Gudnason, Vilmundur (6); Boerwinkle, Eric (6); Hottenga, Jouke-Jan (6); Caporaso, Neil E. (6); Wu, Xifeng (6); Woll, Penella (6); show less...

University: Lund University (24); Karolinska Institutet (23); Umeå University (17); Uppsala University (13); University of Gothenburg (9); Örebro University (2); show more...; Linköping University (2); Stockholm University (1); Karlstad University (1); show less...

Language: English (46)

Research subject (UKÄ/SCB): Medical and Health Sciences (36); Natural sciences (4); Engineering and Technology (1); Humanities (1)

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