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Androgen receptor p...
Androgen receptor polymorphism, testosterone levels, and prognosis in patients with acute myocardial infarction
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- Wang, Anne (author)
- Karolinska Institutet
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- Flanagan, John (author)
- Center for Andrology and Sexual Medicine (ANOVA), Department of Medicine, Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden
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- Arver, Stefan (author)
- Center for Andrology and Sexual Medicine (ANOVA), Department of Medicine, Huddinge, Karolinska Institutet, Stockholm 141 86, Sweden
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- Norhammar, Anna (author)
- Karolinska Institutet
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- Näsman, Per, Docent, 1954- (author)
- KTH,Fastighetsekonomi och finans
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- Rydén, Lars (author)
- Karolinska Institutet
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- Mellbin, Linda G. (author)
- Cardiology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm 171 76, Sweden; Heart and Vascular Theme, Karolinska University Hospital, Stockholm 171 76, Sweden
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(creator_code:org_t)
- 2021-08-25
- 2021
- English.
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In: European Heart Journal Open. - : Oxford University Press (OUP). - 2752-4191. ; 1:2
- Related links:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Aims Low testosterone has been associated with cardiovascular disease in men but with contradictory findings. Testosterone bind to the androgen receptor and polymorphisms of the receptor gene such as CAG repeat length may affect transcriptional activity, possibly mitigating testosterone effects. The aims were to study the CAG repeat length and testosterone levels at four time points following a myocardial infarction (MI) and to analyse possible relationships between CAG repeat length and cardiovascular prognosis. Methods and results Male patients admitted for acute MI (n = 122) from the Glucose in Acute Myocardial Infarction study were included. Blood samples were drawn at four time points (day after admission, at discharge, and at 3 and 12 months post-infarction) for assessment of testosterone levels. Patients were followed for a median of 11.6 years. Cox regression analyses were performed for CAG repeat length by one unit increment and by > vs. <_median for cardiovascular events and all-cause mortality. Median CAG repeat length was 20. There was no difference in testosterone levels at each time point when dividing the cohort into <_ vs. >CAG repeat median (=20). There was no association between CAG repeat length either as a continuous or categorical variable in unadjusted and age-adjusted Cox analyses for cardiovascular events. While CAG >20 was associated with all-cause mortality in unadjusted analyses (hazard ratio 2.19, 95% confidence interval 1.13–4.22; P = 0.02), it did not remain significant following adjustment for age. Conclusion CAG repeat length was not associated with testosterone levels or prognosis in men with acute MI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Androgen receptor
- Cardiovascular disease
- Diabetes
- Genetics
- Testosterone
Publication and Content Type
- ref (subject category)
- art (subject category)
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