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Träfflista för sökning "WFRF:(Arvidsson B) ;pers:(Sander B)"

Sökning: WFRF:(Arvidsson B) > Sander B

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1.
  • Lord, M, et al. (författare)
  • Impact of Sox11 over-expression in Ba/F3 cells
  • 2018
  • Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 103:12, s. E594-E597
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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3.
  • Sadeghi, L, et al. (författare)
  • Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells
  • 2020
  • Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 12:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Interactions between lymphoma cells and stromal cells play a key role in promoting tumor survival and development of drug resistance. We identified differences in key signaling pathways between the JeKo-1 and REC-1 mantle cell lymphoma (MCL) cell lines, displaying different patterns of stromal cell adhesion and chemotaxis towards stroma-conditioned medium. The identified adhesion-regulated genes reciprocated important aspects of microenvironment-mediated gene modulation in MCL patients. Five-hundred and ninety genes were differently regulated between the cell lines upon adhesion to stromal cells, while 32 genes were similarly regulated in both cell lines. Regulation of B-cell Receptor (BCR) signature genes in adherent cells was specific for JeKo-1. Inhibition of BCR using siRNA or clinically approved inhibitors, Ibrutinib and Acalabrutinib, decreased adhesion of JeKo-1, but not REC-1 cells. Cell surface levels of chemokine receptor CXCR4 were higher in JeKo-1, facilitating migration and adhesion of JeKo-1 but not REC-1 cells. Surface levels of ICAM1 adhesion protein differ for REC-1 and JeKo-1. While ICAM1 played a positive role in adherence of both cell lines to stromal cells, S1PR1 had an inhibitory effect. Our results provide a model framework for further investigation of mechanistic differences in patient-response to new pathway-specific drugs.
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  • Resultat 1-3 av 3

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