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Sökning: WFRF:(Asadzadeh F)

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  • Asadzadeh, Mohammad, 1952, et al. (författare)
  • Discontinuous Galerkin and multiscale variational schemes for a coupled damped nonlinear system of Schrödinger equations
  • 2013
  • Ingår i: Numerical Methods for Partial Differential Equations. - : Wiley. - 0749-159X .- 1098-2426. ; 29:6, s. 1912-1945
  • Tidskriftsartikel (refereegranskat)abstract
    • In this article, we study a streamline diffusion-based discontinuous Galerkin approximation for the numerical solution of a coupled nonlinear system of Schrödinger equations and extend the resulting method to a multiscale variational scheme. We prove stability estimates and derive optimal convergence rates due to the maximal available regularity of the exact solution. In the weak formulation, to make the underlying bilinear form coercive, it was necessary to supply the equation system with an artificial viscosity term with a small coefficient of order proportional to a power of mesh size. We justify the theory by implementing an example of an application of the time-dependent Schrödinger equation in the coupled ultrafast laser.
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  • Stacey, Simon N, et al. (författare)
  • Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.
  • 2010
  • Ingår i: PLoS genetics. - : Public Library of Science. - 1553-7404. ; 6:7, s. e1001029-
  • Tidskriftsartikel (refereegranskat)abstract
    • We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case:control samples of Asian, European, and African origin, a total of 10,176 cases and 13,286 controls. We found that rs2046210[T] does not confer substantial risk of breast cancer in Europeans and Africans (OR = 1.04, P = 0.099, and OR = 0.98, P = 0.77, respectively). Rather, in those ancestries, an association signal arises from a group of less common SNPs typified by rs9397435. The rs9397435[G] allele was found to confer risk of breast cancer in European (OR = 1.15, P = 1.2 x 10(-3)), African (OR = 1.35, P = 0.014), and Asian (OR = 1.23, P = 2.9 x 10(-4)) population samples. Combined over all ancestries, the OR was 1.19 (P = 3.9 x 10(-7)), was without significant heterogeneity between ancestries (P(het) = 0.36) and the SNP fully accounted for the association signal in each ancestry. Haplotypes bearing rs9397435[G] are well tagged by rs2046210[T] only in Asians. The rs9397435[G] allele showed associations with both estrogen receptor positive and estrogen receptor negative breast cancer. Using early-draft data from the 1,000 Genomes project, we found that the risk allele of a novel SNP (rs77275268), which is closely correlated with rs9397435, disrupts a partially methylated CpG sequence within a known CTCF binding site. These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping.
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