SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Asplund K) ;lar1:(umu)"

Sökning: WFRF:(Asplund K) > Umeå universitet

  • Resultat 1-10 av 13
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Janunger, Tomas, et al. (författare)
  • A novel stroke locus identified in a northern Sweden pedigree : linkage to chromosome 9q31-33.
  • 2009
  • Ingår i: Neurology. - 0028-3878 .- 1526-632X. ; 73:21, s. 1767-1773
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: The population of northern Sweden is characterized by reduced genetic diversity and a high incidence of stroke. We sought to reduce genetic variation further, using genealogic analysis in a set of nuclear families affected by stroke, and we subsequently performed a genome-wide scan to identify novel stroke susceptibility loci. METHODS: Through genealogy, 7 nuclear families with a common ancestor, connected over 8 generations, were identified. A genome-wide scan using 449 microsatellite markers was performed with subsequent haplotype analyses. RESULTS: A maximum allele-sharing lod score of 4.81 on chromosome 9q31-q33 was detected. Haplotype analysis identified a common 2.2-megabase interval in the chromosomal region in 4 of the nuclear families, where an overrepresentation of intracerebral hemorrhage was observed. CONCLUSIONS: We have identified a novel susceptibility locus for stroke. Haplotype analysis suggests that a shared genetic factor is of particular importance for intracerebral hemorrhage.
  •  
2.
  • Rydvall, A., et al. (författare)
  • Plasma cortisol is often decreased in patients treated in an intensive care unit
  • 2000
  • Ingår i: Intensive Care Med. ; 26:5, s. 545-51
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To investigate the prevalence of adrenal hypofunction, as assessed by plasma cortisol (p-cortisol) and its relationship to clinical events. DESIGN: Prospective, consecutive. SETTING: General intensive care unit in a university hospital. PATIENTS: Fifty-five patients (34 men and 21 women) were studied (surgery 40 patients, hemodialysis 5, ventilator treatment 45, sepsis 21). METHODS: Morning basal levels of p-cortisol were determined. Previous reports define adrenal insufficiency to be present if p-cortisol under stressful conditions is lower than either 400 or 500 nmol/l. The tetracosactoid test (250 microg Synacthen) was performed in 16 patients and urinary 24-h excretion of cortisol in 24 (none on corticosteroid treatment). RESULTS: Median p-cortisol was 550 nmol/l (range 20-1764). In 36% of patients p-cortisol was lower than 400 nmol/l and in 47% lower than 500 nmol/l. There was a significantly increased probability (P < 0.05) of p-cortisol being below 400 nmol/l in patients admitted due to trauma or cerebral disorder and in patients on ventilator therapy or on mannitol. Thirty minutes after tetracosactoid administration p-cortisol response was lower than 200 nmol/l in 56% of the patients. CONCLUSIONS: Several patients had low p-cortisol and attenuated responses to tetracosactoid, indicative of adrenal insufficiency. There seem to be certain risk factors for adrenal hypofunction which may justify more frequent use of physiological doses of corticosteroid in selected patients.
  •  
3.
  • Asplund, K. (författare)
  • Managing risk factors
  • 2011
  • Ingår i: Special Issue. - Oxford : Rapid Communications. ; , s. 621-621
  • Konferensbidrag (refereegranskat)
  •  
4.
  • Chroinin, Danielle Ni, et al. (författare)
  • Statin Therapy and Outcome After Ischemic Stroke : Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials
  • 2013
  • Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 44:2, s. 448-456
  • Forskningsöversikt (refereegranskat)abstract
    • Background and Purpose-Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke. Methods-The primary analysis investigated statin therapy at stroke onset (prestroke statin use) and good functional outcome (modified Rankin score 0 to 2) and death. Secondary analyses included the following: (1) acute poststroke statin therapy (<= 72 hours after stroke), and (2) thrombolysis-treated patients. Results-The primary analysis included 113 148 subjects (27 studies). Among observational studies, statin treatment at stroke onset was associated with good functional outcome at 90 days (pooled odds ratio [OR], 1.41; 95% confidence interval [CI], 1.29-1.56; P<0.001), but not 1 year (OR, 1.12; 95% CI, 0.9-1.4; P=0.31), and with reduced fatality at 90 days (pooled OR, 0.71; 95% CI, 0.62-0.82; P<0.001) and 1 year (OR, 0.80;95% CI, 0.67-0.95; P=0.01). In the single randomized controlled trial reporting 90-day functional outcome, statin treatment was associated with good outcome (OR, 1.5; 95% CI, 1.0-2.24; P=0.05). No reduction in fatality was observed on meta-analysis of data from 3 randomized controlled trials (P=0.9). In studies restricted to of thrombolysis-treated patients, an association between statins and increased fatality at 90 days was observed (pooled OR, 1.25; 95% CI, 1.02-1.52; P=0.03, 3 studies, 4339 patients). However, this association was no longer present after adjusting for age and stroke severity in the largest study (adjusted OR, 1.14; 95% CI, 0.90-1.44; 4012 patients). Conclusion-In the largest meta-analysis to date, statin therapy at stroke onset was associated with improved outcome, a finding not observed in studies restricted to thrombolysis-treated patients. Randomized trials of statin therapy in acute ischemic stroke are needed.
  •  
5.
  • Hyytiainen, Heli K., et al. (författare)
  • A systematic review of complementary and alternative veterinary medicine in sport and companion animals : electrotherapy
  • 2023
  • Ingår i: Animals. - : MDPI. - 2076-2615. ; 13:1
  • Forskningsöversikt (refereegranskat)abstract
    • Electrotherapy modalities are currently used in the treatment of animals, but the evidence base supporting their use has not yet been systematically reviewed. Cochrane guidelines, as adapted by the Swedish Agency for Health Technology Assessment and Assessment of Social Services, were followed for this systematic review. A literature search regarding all currently known electrotherapy modalities applied to horses, dogs, and cats was conducted for the years 1980–2020 using three databases: CABI, PubMed, and Web of Science Core Collection. Of the 5385 references found, 41 articles were included in the review: 13 papers on pulsed electromagnetic field therapy (PEMFT), 7 on neural electrical muscle stimulation (NEMS), 5 on transcutaneous electrical nerve stimulation (TENS), 4 on static magnets, 3 on interference, 2 each on percutaneous electrical neural stimulation (PENS), bioelectricity, and diathermy, and 1 each on micro-pulsed stimulation, capacitive coupled electrical stimulation, and microwave therapy. The literature per modality was limited in quantity (mean 3.7 papers). Half of the articles were assessed to have a high risk of bias (20 high, 7 moderate, and 14 low). The existing literature used a spectrum of indications and treatment parameters, which makes comparisons and drawing conclusions to support the use of these modalities in clinical practice challenging. The current scientific evidence is not sufficient to support the clinical effects of electrotherapies for any clinical indication in horses, dogs or cats. The selected suggestive results warrant further high-quality research on PEMFT, NEMS, TENS, and PENS.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 13
Typ av publikation
tidskriftsartikel (5)
annan publikation (4)
konferensbidrag (2)
forskningsöversikt (2)
Typ av innehåll
refereegranskat (9)
övrigt vetenskapligt/konstnärligt (4)
Författare/redaktör
Asplund, K (7)
Asplund, Kjell (4)
Stegmayr, Birgitta (2)
Stegmayr, B (2)
Wiklund, P G (2)
Holmberg, D. (2)
visa fler...
Farahmand, B (1)
Norrving, B (1)
Ahren, B (1)
Eriksson, M (1)
Adolfsson, Rolf (1)
Thrift, Amanda G. (1)
Henriksson, Karin (1)
Norrving, Bo (1)
Olsson, Tommy (1)
Martí-Fàbregas, Joan (1)
Lindgren, P (1)
Hallmans, G (1)
Holmberg, Dan (1)
Söderberg, Stefan (1)
Terent, Andreas (1)
Lundgren, K (1)
Bergh, Anna (1)
Engelter, Stefan T (1)
Rost, Natalia S. (1)
Montaner, Joan (1)
Furie, Karen L. (1)
Cuadrado-Godia, Elis ... (1)
Haglund, Peter (1)
Wiklund, Per-Gunnar (1)
Eriksson, Marie (1)
Mattsson, B (1)
Wimo, A (1)
Åsberg, Signild, 197 ... (1)
Jonsson, Fredrik (1)
Asplund, Kenneth (1)
Asplund, L (1)
Löfstrand, K (1)
Malmvärn, A (1)
Jansson, J-H (1)
Nilsson, A K (1)
Probstfield, Jeffrey (1)
Rydvall, A. (1)
Wester, P O (1)
Janunger, Tomas (1)
Kapral, Moira K (1)
Bergman, Å. (1)
Carlberg, B (1)
Chroinin, Danielle N ... (1)
Callaly, Elizabeth (1)
visa färre...
Lärosäte
Uppsala universitet (1)
Lunds universitet (1)
Mittuniversitetet (1)
Sveriges Lantbruksuniversitet (1)
Språk
Engelska (13)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (7)
Naturvetenskap (1)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy