SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Axelsson Anders) ;mspu:(publicationother)"

Sökning: WFRF:(Axelsson Anders) > Annan publikation

  • Resultat 1-8 av 8
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Essving, Per, 1960-, et al. (författare)
  • Minimally invasive surgery did not improve outcome compared to conventional surgery following unicompartmental knee arthroplasty when using local infiltration analgesia
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Background and purpose: There has recently been focus on the advantages of minimally invasive surgery (MIS) over conventional surgery and on local infiltration analgesia (LIA) during knee arthroplasty. This prospective randomized controlled trial investigated whether MIS would result in earlier home readiness and reduced postoperative pain compared to conventional unicompartmental knee arthroplasty (UKA) where both groups received LIA. Patients and methods: 40 patients scheduled for UKA were randomized to group MIS or group CON (conventional surgery). Both groups received LIA, with a mixture of ropivacaine, ketorolac, and epinephrine, intra- and postoperatively. The primary endpoint was home readiness (time to fulfillment of discharge criteria). The patients were followed for 6 months. Results: We found no statistically significant difference in home readiness between group MIS, median (range) 24 (21–71) h compared to group CON, 24 (21–46) h. No statistically significant differences between the groups were found in the secondary endpoints: pain intensity, morphine consumption, knee function, hospital stay, patient satisfaction, Oxford Knee Score and EQ-5D. The side effects between the groups were also similar, except a higher incidence of nausea on the second postoperative day in group MIS compared with group CON. Interpretation: Minimally invasive surgery did not improve outcome after unicompartmental knee arthroplasty compared to conventional surgery, when both groups received local infiltration analgesia. The surgical approach (MIS or conventional surgery) should be selected according to surgeon’s preferences and local hospital policies. ClinicalTrials.gov. (Identifier NCT00991445). 
  •  
2.
  •  
3.
  •  
4.
  • Fant, Federica, et al. (författare)
  • Thoracic epidural analgesia inhibits the neuro-hormonal but not the acute inflammatory stress response following radical retropubic prostatectomy
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Background: Epidural anesthesia and analgesia has been shown to suppress the neurohormonalstress response in certain types of surgery, but its role in the inflammatory responseto surgery is unclear. The primary aim of this study was to assess whether the choice ofanalgesic technique influences these processes in patients undergoing radical retropubicprostatectomy (RRP).Method: 26 patients undergoing RRP were randomized to Group P (systemic opioid-basedanalgesia) or Group E (thoracic epidural-based analgesia) perioperatively. Induction andmaintenance of anesthesia in both groups followed a standardized protocol. The followingmeasurements were made perioperatively : plasma cortisol, glucose, insulin, plasma cytokines(IL-6, TNF-a) and pokeweed mitogen-stimulated cytokines (IFN-g, IL-2, IL-12p70, IL-10,IL-4, and IL-17), C-reactive proteins and leucocyte count. Other parameters recordedincluded pain, morphine consumption and perioperative complications during 72 hours.Results: Plasma concentration of cortisol and glucose were significantly higher in Group Pcompared to Group E at the end of surgery with a mean difference between groups of 232nmol/L (95% CI 84-381) (P=0.004) and 1.6 mmol/L (95% CI 0.6-2.5) (P=0.003) respectively.No significant differences were seen in any plasma cytokine except IL-17, which was higherin Group P compared with Group E, both at 24 h (P< 0.001) and 72 h (P=0.018)postoperatively. Significantly higher pain intensity was seen up to 24 hours postoperatively inGroup P compared to Group E (p < 0.05).Conclusion: Thoracic epidural analgesia reduces the early postoperative stress response butnot the acute inflammatory response to radical retrobupic prostatectomy suggesting that otherpathways are involved during the acute phase reaction.
  •  
5.
  •  
6.
  •  
7.
  • Perniola, Andrea, et al. (författare)
  • Local anesthetics administered intra-peritoneally have predominant localand not central analgesic effect : a randomized, double blind study
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Background It remains unclear whether the analgesic effect of intraperitoneal local anesthetics (LA) is via local intraperitoneal or central mechanisms. This double blind, randomized study was performed to test the hypothesis that LA given intraperitoneally (IP) are superior to the same dose administered by continuous IV infusion (IV) for treating postoperative pain.Methods A multi-hole catheter was placed intraperitoneally at the end of the surgery in 60 patients undergoing elective abdominal hysterectomy. The patients were randomized to: Group IV: a continuous infusion of lidocaine 50 mg/h (10 ml) IV and saline 10 ml/h intermittently IPGroup IP: an injection of lidocaine 50 mg/h (10ml) once every hour IP and a continuous infusion of saline 10 ml/h IV. Group P: saline 10 ml/h both as continuous IV infusion and intermittent IP injection. Postoperative morphine consumption, pain intensity, recovery parameters, home discharge and lidocaine concentrations were measured.ResultsMorphine consumption during 0-24h was lower in Group IP vs. Group IV, mean difference - 22.6 mg (95% CI, 11.4 to 33.8, p < 0.01). No difference was seen between Group IV and Group P in analgesic consumption. The total mean plasma concentration of lidocaine in Group IP was significantly lower than in Group IV, 0 - 4.5h postoperatively (p = 0.03). Pain intensity, recovery parameters and time to home discharge were similar between the groups.Conclusion The lower supplemental morphine consumption coupled with a lower plasma lidocaine concentration following intraperitoneal administration would confirm a predominant local rather than central effect of local anesthetics.
  •  
8.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-8 av 8

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy