| 1. |
- Hibar, Derrek P., et al.
(författare)
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Novel genetic loci associated with hippocampal volume
- 2017
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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| 2. |
- Satizabal, Claudia L., et al.
(författare)
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Genetic architecture of subcortical brain structures in 38,851 individuals
- 2019
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:11, s. 1624-
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Tidskriftsartikel (refereegranskat)abstract
- Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
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| 3. |
- Axelsson, Louise, 1990, et al.
(författare)
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The Characteristics of Excellent Designers - Findings from an Interview Study with Swedish Innovators
- 2015
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Ingår i: Proceedings of the International Conference on Engineering Design, ICED. - 2220-4334 .- 2220-4342. - 9781904670711 ; 80:DS 80-08, s. 131-140
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Konferensbidrag (refereegranskat)abstract
- Some designers are more successful than others. They have the ability to repeatedly generate new and innovative solutions to challenging problems. In this paper, we refer to designers who possess this level of skill as “excellent designers”. It would seem interesting to identify the characteristics of such individuals in order to better understand why they succeed while ordinary designer do not. However, there have been few published studies of excellent designers, and these studies have focused on one or a few individuals.In this paper, we account for a study of a larger group (15) of excellent designers. The aims were first to identify their particular set of knowledge, experience, working practices and personal characteristics and then to use the findings to generate proposals for how employers and educator can nurture excellent designers.
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| 4. |
- Ideland, Malin, 1970-, et al.
(författare)
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”En hemlig skola röjer det orimliga"
- 2020
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Ingår i: Svenska Dagbladet. - Stockholm : Svenska Dagbladet. - 1101-2412. ; :2020-08-30
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Det är affärslogiken som styr när statistik om skolor och betyg nu ska sekretessbeläggas. Samtidigt visar detta hemlighetsmakeri tydligt att friskolan blivit norm och att andra värden felaktigt får stå tillbaka, skriver forskare.
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| 6. |
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| 7. |
- Svetoft, Ingrid, 1959-, et al.
(författare)
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Rapport 2014 – den goda och hållbara plan- och byggprocessen
- 2014
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Rapport (populärvet., debatt m.m.)abstract
- Det finns flera olika anledningar till att förstudien “Den goda och hållbara plan-och byggprocessen” startades upp under våren 2014. Ett flertal aktiviter arrangerade av det halländska företagsnätverket Energi-och Miljöcentrum (EMC) i Varberg har sammanfört ett antal olika aktörer som annars inte vanligtvis möts. I dessa möten har idéer och inspirerande samtal förts som lett till en gemensam vilja att samverka i olika frågor. I denna rapport beskrivs bakgrund och genomförande av förstudien samt några sammanfattande resultat. Ett antal reflektioner om framtida möjligheter presenteras i slutet av rapporten. Alexandersoninstitutet har med sitt uppdrag gett möjligheten till oss på Högskolan i Halmstad att samordna ett antal möten och problemformulera processer och dialoger med koppling planering och byggande. Uppdraget har finansierats av Europeiska Regionalfonden via projektet Efterfrågad Utveckling. Resultatet har blivit ett antal temaformuleringar och case som nu kan användas för fortsatt arbete med forskningsansökningar och spridning av erfarenheter.
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| 8. |
- Tang, Lifei, et al.
(författare)
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A deep learning based sensor fusion method to diagnose tightening errors
- 2023
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Ingår i: Journal of manufacturing systems. - : Elsevier. - 0278-6125 .- 1878-6642. ; 71, s. 59-69
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Tidskriftsartikel (refereegranskat)abstract
- Modern smart assembly lines commonly include electric tools with built-in sensors to tighten safety-critical joints. These sensors generate data that are subsequently analyzed by human experts to diagnose potential tightening errors. Previous research aimed to automate the diagnosing process by developing diagnosing models based on tightening theory and calibration of the friction coefficient in specific lab setups. Generalizing these results is difficult and often unsuccessful since friction coefficients vary between lab and production environments. To overcome this problem, this paper presents a novel methodology that builds multi-label classification deep learning models for diagnosing tightening errors using production data. The proposed methodology comprises three key contributions, i.e., the Labrador method, the Model Combo (MoBo) framework, and a heuristic evaluation method. Labrador is an elastic deep learning based sensor fusion method that (1) uses feature encoders to extract features; (2) conducts data-level and/or feature-level sensor fusion in both time and frequency domains; and (3) performs multi-label classification to detect and diagnose tightening errors. MoBo is a configurable and modular framework that supports Labrador in identifying optimal feature encoders. With MoBo and Labrador, one can easily explore and design a bounded search space for sensor fusion strategies (SFSs) and feature encoders. In order to identify the optimal solution within the defined search space, this paper introduces a heuristic method. By evaluating the trade-off between machine learning (ML) metrics (e.g., accuracy, subset accuracy, and F1) and operational (OP) metrics (e.g., inference latency), the proposed method identifies the most suitable solution depending on the requirements of individual use cases. In the experimental evaluation, we adopt the proposed methodology to identify the most suitable multi-label classification solutions for diagnosing tightening errors. To optimize ML metrics, the identified solution achieved 99.69% accuracy, 93.39% subset accuracy, 97.39% F1, and 6.68ms inference latency. To optimize OP metrics, the identified solution achieved 99.66% accuracy, 92.65% subset accuracy, 97.28% F1, and 2.41ms inference latency.
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| 9. |
- Waldenström, Jonas, et al.
(författare)
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Campylobacter jejuni colonization in wild birds: results from an infection experiment.
- 2010
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 5:2
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Tidskriftsartikel (refereegranskat)abstract
- Campylobacter jejuni is a common cause of bacterial gastroenteritis in most parts of the world. The bacterium has a broad host range and has been isolated from many animals and environments. To investigate shedding patterns and putative effects on an avian host, we developed a colonization model in which a wild bird species, the European Robin Erithacus rubecula, was inoculated orally with C. jejuni from either a human patient or from another wild bird species, the Song Thrush Turdus philomelos. These two isolates were genetically distinct from each other and provoked very different host responses. The Song Thrush isolate colonized all challenged birds and colonization lasted 6.8 days on average. Birds infected with this isolate also showed a transient but significant decrease in body mass. The human isolate did not colonize the birds and could be detected only in the feces of the birds shortly after inoculation. European Robins infected with the wild bird isolate generated a specific antibody response to C. jejuni membrane proteins from the avian isolate, which also was cross-reactive to membrane proteins of the human isolate. In contrast, European Robins infected with the human isolate did not mount a significant response to bacterial membrane proteins from either of the two isolates. The difference in colonization ability could indicate host adaptations.
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