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Sökning: WFRF:(Backman Helena) > Uppsala universitet

  • Resultat 1-10 av 32
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  • 2019
  • Tidskriftsartikel (refereegranskat)
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  • Backman, Dan, 1972- (författare)
  • Interaction Studies of Secreted Aspartic Proteases (Saps) from Candida albicans : Application for Drug Discovery
  • 2005
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • This thesis is focused on enzymatic studies of the secreted aspartic proteases (Saps) from Candida albicans as a tool for discovery of anti-candida drugs. C. albicans causes infections in a number of different locations, which differ widely in the protein substrates available and pH. Since C. albicans needs Saps during virulent growth, these enzymes are good targets for drug development.In order to investigate the catalytic characteristics of Saps and their inhibitor affinities, substrate-based kinetic assays were developed. Due to the low sensitivity of these assays, especially at the sub-optimal pH required to mimic the different locations of infections, these assays were not satisfactory. Therefore, a biosensor assay was developed whereby, it was possible to study interaction between Saps and inhibitors without the need to optimise catalytic efficacy. Furthermore, the biosensor assay allowed determination of affinity, as well as the individual association and dissociation rates for inhibitor interactions.Knowledge about substrate specificity, Sap subsite adaptivity, and the pH dependencies of catalytic efficacy has been accumulated. Also, screening of transition-state analogue inhibitors designed for HIV-1 protease has revealed inhibitors with affinity for Saps. Furthermore, the kinetics and pH dependencies of their interaction with Saps have been investigated. One of these inhibitors, BEA-440, displayed a complex interaction with Saps, indicating a conformational change upon binding and a very slow dissociation rate. A time dependent interaction was further supported by inhibition measurements. The structural information obtained affords possibilities for design of new more potent inhibitors that might ultimately become drugs against candidiasis. The strategy to combine substrate specificity studies with inhibitor screening has led to complementary results that generate a framework for further development of potent inhibitors.
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  • Backman, Helena, 1969- (författare)
  • Ett bokbyte över gränserna : Andreas Kallström som kommissionär åt bröderna Bergius på 1760-talet
  • 2017
  • Ingår i: Svenska Linnésällskapets årsskrift. - Uppsala : Svenska Linnésällskapet. - 0375-2038. ; , s. 113-124
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • A Book Exchange Across BordersAndreas Kallström as an Agent for the Bergius Brothers in the 1760sThe article tells about a book exchange in 1765 between Peter Jonas and Bengt Bergius and an anonymous English gentleman through the help of Andreas Kallström, a Swedish student of botany and horticulture, during his stay in London 1764-1765 as a part of his studies. The correspondence between the Bergius brothers and Kallström shows that the exchange was unprofessionally handled and troublesome for Kallström. However, he manages to get the books that the brothers Bergius wished for before leaving London for Paris. The correspondence gives us also clues on the importance of the bookbindings, as well as other material aspects of the book, as part of the commerce with books during the later eighteenth century. Different aspects on the exchange of books across the Swedish borders give us a fuller picture of the commerce at the time.
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  • Backman, Helena, 1969- (författare)
  • J. F. Wettergrens "Lån-bibliothek" i Skara
  • 2023
  • Ingår i: Ett och annat från den gamla Staden Skara. - Skara : Skara Gille. ; 2022/2023, s. 23-26
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Om Johan Fredrik Wettergrens lånebibliotek grundat 1835 i Skara.
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