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Sökning: WFRF:(Backman Samuel)

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  • Bengtsson, Daniel, et al. (författare)
  • Corticotroph Pituitary Carcinoma in a Patient With Lynch Syndrome (LS) and Pituitary Tumors in a Nationwide LS Cohort
  • 2017
  • Ingår i: The Journal of clinical endocrinology and metabolism. - Oxford University Press. - 1945-7197. ; 102:11, s. 3928-3932
  • Tidskriftsartikel (refereegranskat)abstract
    • Context: Lynch syndrome (LS) is a cancer-predisposing syndrome caused by germline mutations in genes involved in DNA mismatch repair (MMR). Patients are at high risk for several types of cancer, but pituitary tumors have not previously been reported.Case: A 51-year-old man with LS (MSH2 mutation) and a history of colon carcinoma presented with severe Cushing disease and a locally aggressive pituitary tumor. The tumor harbored a mutation consistent with the patient's germline mutation and displayed defect MMR function. Sixteen months later, the tumor had developed into a carcinoma with widespread liver metastases. The patient prompted us to perform a nationwide study in LS.Nationwide Study: A diagnosis consistent with a pituitary tumor was sought for in the Swedish National Patient Registry. In 910 patients with LS, representing all known cases in Sweden, another two clinically relevant pituitary tumors were found: an invasive nonsecreting macroadenoma and a microprolactinoma (i.e., in total three tumors vs. one expected).Conclusion: Germline mutations in MMR genes may contribute to the development and/or the clinical course of pituitary tumors. Because tumors with MMR mutations are susceptible to treatment with immune checkpoint inhibitors, we suggest to actively ask for a family history of LS in the workup of patients with aggressive pituitary tumors.
  • Shah, Sonia, et al. (författare)
  • Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
  • 2020
  • Ingår i: Nature Communications. - NATURE PUBLISHING GROUP. - 2041-1723 .- 2041-1723. ; 11:1
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.</p>
  • Backman, Filip, et al. (författare)
  • ATLAS b-jet identification performance and efficiency measurement with t(t)over-bar events in pp collisions at root s=13 TeV
  • 2019
  • Ingår i: European Physical Journal C. - 1434-6044 .- 1434-6052. ; 79:11
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The algorithms used by the ATLAS Collaboration during Run 2 of the Large Hadron Collider to identify jets containing b-hadrons are presented. The performance of the algorithms is evaluated in the simulation and the efficiency with which these algorithms identify jets containing b-hadrons is measured in collision data. The measurement uses a likelihood-based method in a sample highly enriched in t (t) over bar events. The topology of the t -&gt; Wb decays is exploited to simultaneously measure both the jet flavour composition of the sample and the efficiency in a transverse momentum range from 20 to 600 GeV. The efficiency measurement is subsequently compared with that predicted by the simulation. The data used in this measurement, corresponding to a total integrated luminosity of 80.5 fb(-1), were collected in proton-proton collisions during the years 2015-2017 at a centre-of-mass energy root s = 13 TeV. By simultaneously extracting both the efficiency and jet flavour composition, this measurement significantly improves the precision compared to previous results, with uncertainties ranging from 1 to 8% depending on the jet transverse momentum.</p>
  • Backman, Filip, et al. (författare)
  • Combination of searches for Higgs boson pairs in <em>pp</em> collisions at root s=13 TeV with the ATLAS detector
  • 2020
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 800
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>This letter presents a combination of searches for Higgs boson pair production using up to 36.1 fb(-1) of proton-proton collision data at a centre-of-mass energy root s = 13 TeV recorded with the ATLAS detector at the LHC. The combination is performed using six analyses searching for Higgs boson pairs decaying into the b (b) over barb (b) over bar, b (b) over barW(+)W(-), b (b) over bar tau(+)tau(-), W+W-W+W-, b (b) over bar gamma gamma and W+W-gamma gamma final states. Results are presented for non-resonant and resonant Higgs boson pair production modes. No statistically significant excess in data above the Standard Model predictions is found. The combined observed (expected) limit at 95% confidence level on the non-resonant Higgs boson pair production cross-section is 6.9 (10) times the predicted Standard Model cross-section. Limits are also set on the ratio (kappa(lambda)) of the Higgs boson self-coupling to its Standard Model value. This ratio is constrained at 95% confidence level in observation (expectation) to -5.0 &lt; kappa(lambda) &lt; 12.0 (-5.8 &lt; kappa(lambda) &lt; 12.0). In addition, limits are set on the production of narrow scalar resonances and spin-2 Kaluza-Klein Randall-Sundrum gravitons. Exclusion regions are also provided in the parameter space of the habemus Minimal Supersymmetric Standard Model and the Electroweak Singlet Model.</p>
  • Backman, Filip, et al. (författare)
  • Combination of Searches for Invisible Higgs Boson Decays with the ATLAS Experiment
  • 2019
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 122:23
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Dark matter particles, if sufficiently light, may be produced in decays of the Higgs boson. This Letter presents a statistical combination of searches for H -&gt; invisible decays where H is produced according to the standard model via vector boson fusion, Z(ll)H, and W/Z(had)H, all performed with the ATLAS detector using 36.1 fb(-1) of pp collisions at a center-of-mass energy of root s = 13 TeV at the LHC. In combination with the results at root s = 7 and 8 TeV, an exclusion limit on the H -&gt; invisible branching ratio of 0.26(0.17(-0.05)(+0.07)) at 95% confidence level is observed (expected).</p>
  • Backman, Filip, et al. (författare)
  • Combinations of single-top-quark production cross-section measurements and vertical bar f(LV)V(tb)vertical bar determinations at root s=7 and 8 TeV with the ATLAS and CMS experiments
  • 2019
  • Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :5
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>This paper presents the combinations of single-top-quark production cross-section measurements by the ATLAS and CMS Collaborations, using data from LHC proton-proton collisions at = 7 and 8 TeV corresponding to integrated luminosities of 1.17 to 5.1 fb(-1) at = 7 TeV and 12.2 to 20.3 fb(-1) at = 8 TeV. These combinations are performed per centre-of-mass energy and for each production mode: t-channel, tW, and s-channel. The combined t-channel cross-sections are 67.5 +/- 5.7 pb and 87.7 +/- 5.8 pb at = 7 and 8 TeV respectively. The combined tW cross-sections are 16.3 +/- 4.1 pb and 23.1 +/- 3.6 pb at = 7 and 8 TeV respectively. For the s-channel cross-section, the combination yields 4.9 +/- 1.4 pb at = 8 TeV. The square of the magnitude of the CKM matrix element V-tb multiplied by a form factor f(LV) is determined for each production mode and centre-of-mass energy, using the ratio of the measured cross-section to its theoretical prediction. It is assumed that the top-quark-related CKM matrix elements obey the relation |V-td|, |V-ts| &lt;&lt; |V-tb|. All the |f(LV)V(tb)|(2) determinations, extracted from individual ratios at = 7 and 8 TeV, are combined, resulting in |f(LV)V(tb)| = 1.02 +/- 0.04 (meas.) +/- 0.02 (theo.). All combined measurements are consistent with their corresponding Standard Model predictions.</p>
  • Backman, Filip, et al. (författare)
  • Combined measurements of Higgs boson production and decay using up to 80 fb(-1) of proton-proton collision data at root S=13 TeV collected with the ATLAS experiment
  • 2020
  • Ingår i: Physical Review D : covering particles, fields, gravitation, and cosmology. - 2470-0010 .- 2470-0029. ; 101:1
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Combined measurements of Higgs boson production cross sections and branching fractions arc presented. The combination is based on the analyses of the Higgs boson decay modes H -&gt; gamma gamma, ZZ*, WW*, tau tau, b (b) over bar, mu mu, searches for decays into invisible final states, and on measurements of off-shell Higgs boson production. Up to 79.8 fb(-1) of proton-proton collision data collected at root S = 13 TeV with the ATLAS detector are used. Results are presented for the gluon-gluon fusion and vector-boson fusion processes, and for associated production with vector bosons or top-quarks. The global signal strength is determined to be mu = 1.11(-0.08)(+0.09). The combined measurement yields an observed (expected) significance for the vector-boson fusion production process of 6.5 sigma (5.3 sigma). Measurements in kinematic regions defined within the simplified template cross section framework are also shown. The results are interpreted in terms of modifiers applied to the Standard Model couplings of the Higgs boson to other particles, and are used to set exclusion limits on parameters in two-Higgs-doublet models and in the simplified minimal supersynunetric Standard Model. No significant deviations from Standard Model predictions are observed.</p>
  • Backman, Filip, et al. (författare)
  • Constraints on mediator-based dark matter and scalar dark energy models using root s= 13 TeV pp collision data collected by the ATLAS detector
  • 2019
  • Ingår i: Journal of High Energy Physics (JHEP). - 1126-6708 .- 1029-8479. ; :5
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Constraints on selected mediator-based dark matter models and a scalar dark energy model using up to 37 fb(-1) = 13 TeV pp collision data collected by the ATLAS detector at the LHC during 2015-2016 are summarised in this paper. The results of experimental searches in a variety of final states are interpreted in terms of a set of spin-1 and spin-0 single-mediator dark matter simplified models and a second set of models involving an extended Higgs sector plus an additional vector or pseudo-scalar mediator. The searches considered in this paper constrain spin-1 leptophobic and leptophilic mediators, spin-0 colour-neutral and colour-charged mediators and vector or pseudo-scalar mediators embedded in extended Higgs sector models. In this case, also = 8 TeV pp collision data are used for the interpretation of the results. The results are also interpreted for the first time in terms of light scalar particles that could contribute to the accelerating expansion of the universe (dark energy).</p>
  • Backman, Filip, et al. (författare)
  • Electron and photon performance measurements with the ATLAS detector using the 2015-2017 LHC proton-proton collision data
  • 2019
  • Ingår i: Journal of Instrumentation. - 1748-0221 .- 1748-0221. ; 14
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>This paper describes the reconstruction of electrons and photons with the ATLAS detector, employed for measurements and searches exploiting the complete LHC Run 2 dataset. An improved energy clustering algorithm is introduced, and its implications for the measurement and identification of prompt electrons and photons are discussed in detail. Corrections and calibrations that affect performance, including energy calibration, identification and isolation efficiencies, and the measurement of the charge of reconstructed electron candidates are determined using up to 81 fb(-1) of proton-proton collision data collected at root s = 13 TeV between 2015 and 2017.</p>
  • Backman, Filip, et al. (författare)
  • Evidence for electroweak production of two jets in association with a Z gamma pair in <em>pp</em> collisions at root S=13 TeV with the ATLAS detector
  • 2020
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 803
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Evidence for electroweak production of two jets in association with a Z gamma pair in root s = 13 TeV proton-proton collisions at the Large Hadron Collider is presented. The analysis uses data collected by the ATLAS detector in 2015 and 2016 that corresponds to an integrated luminosity of 36.1 fb(-1). Events that contain a Z boson candidate decaying leptonically into either e(+)e(-) or mu(+)mu(-), a photon, and two jets are selected. The electroweak component is measured with observed and expected significances of 4.1 standard deviations. The fiducial cross-section for electroweak production is measured to be sigma(Z gamma jj-Ew) = 7.8 +/- 2.0 fb, in good agreement with the Standard Model prediction.</p>
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