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Predictive molecula...
Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe
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- Malapelle, Umberto (author)
- University of Naples Federico II
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- Pisapia, Pasquale (author)
- University of Naples Federico II
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- Iaccarino, Antonino (author)
- University of Naples Federico II
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- Barberis, Massimo (author)
- European Institute of Oncology
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- Bellevicine, Claudio (author)
- University of Naples Federico II
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- Brunnström, Hans (author)
- Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- de Biase, Dario (author)
- University of Bologna
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- de Maglio, Giovanna (author)
- University Hospital of Udine
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- Lindquist, Kajsa Ericson (author)
- Lund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Fassan, Matteo (author)
- University of Padova
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- Fontanini, Gabriella (author)
- University of Pisa
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- Gruppioni, Elisa (author)
- University of Bologna
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- Hofman, Paul (author)
- Institut Gustave Roussy
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- Merkelbach-Bruse, Sabine (author)
- University Hospital of Cologne
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- Molina Vila, Miguel A. (author)
- Pangaea Oncology
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- Pujals, Anaïs (author)
- Henri Mondor Hospital
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- Rapa, Ida (author)
- San Luigi University Hospital
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- Righi, Luisella (author)
- University of Turin
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- Rosell, Rafael (author)
- Hospital Universitari Germans Trias i Pujol
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- Schildgen, Oliver (author)
- Witten/Herdecke University
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- Schildgen, Verena (author)
- Witten/Herdecke University
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- Schmitt, Fernando C. (author)
- University of Porto
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- Tallini, Giovanni (author)
- University of Bologna
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- Borght, Sara Vander (author)
- University Hospitals Leuven
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- Vigliar, Elena (author)
- University of Naples Federico II
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- Volante, Marco (author)
- University of Turin
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- Wagener-Ryczek, Svenja (author)
- University Hospital of Cologne
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- Weynand, Birgit (author)
- University Hospitals Leuven
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- Troncone, Giancarlo (author)
- University of Naples Federico II
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(creator_code:org_t)
- 2020-07-31
- 2021
- English 5 s.
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In: Journal of Clinical Pathology. - : BMJ. - 0021-9746 .- 1472-4146. ; 74:6, s. 391-395
- Related links:
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http://dx.doi.org/10...
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https://jcp.bmj.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Aims Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. Methods Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time. Results In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing. Conclusions The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- art (subject category)
- ref (subject category)
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Malapelle, Umber ...
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Pisapia, Pasqual ...
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Iaccarino, Anton ...
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Barberis, Massim ...
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Bellevicine, Cla ...
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Brunnström, Hans
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de Biase, Dario
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de Maglio, Giova ...
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Lindquist, Kajsa ...
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Fassan, Matteo
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Fontanini, Gabri ...
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Gruppioni, Elisa
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Hofman, Paul
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Merkelbach-Bruse ...
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Molina Vila, Mig ...
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Pujals, Anaïs
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Rapa, Ida
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Righi, Luisella
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Rosell, Rafael
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Schildgen, Olive ...
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Schildgen, Veren ...
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Schmitt, Fernand ...
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Tallini, Giovann ...
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Borght, Sara Van ...
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Vigliar, Elena
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Volante, Marco
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Wagener-Ryczek, ...
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Weynand, Birgit
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Troncone, Gianca ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Lund University