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- Barnabe-Heider, F, et al.
(författare)
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Stem cells for spinal cord repair
- 2008
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Ingår i: Cell stem cell. - : Elsevier BV. - 1875-9777 .- 1934-5909. ; 3:1, s. 16-24
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Tidskriftsartikel (refereegranskat)
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- Carlen, M, et al.
(författare)
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Genetic visualization of neurogenesis
- 2006
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Ingår i: Experimental cell research. - : Elsevier BV. - 0014-4827. ; 312:15, s. 2851-2859
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Tidskriftsartikel (refereegranskat)
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- Forsberg, M, et al.
(författare)
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Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene
- 2010
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 107:33, s. 14657-14661
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Tidskriftsartikel (refereegranskat)abstract
- Neural stem cells have a broad differentiation repertoire during embryonic development and can be reprogrammed to pluripotency comparatively easily. We report that adult neural stem cells can be reprogrammed at very high efficiency to monocytes, a differentiated fate of an unrelated somatic lineage, by ectopic expression of the Ets transcription factor PU.1. The reprogrammed cells display a marker profile and functional characteristics of monocytes and integrate into tissues after transplantation. The failure to reprogram lineage-committed neural cells to monocytes with PU.1 suggests that neural stem cells are uniquely amenable to reprogramming.
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