Short-term effects of repetitive arm work and dynamic exercise on glucose metabolism and insulin sensitivity.

• Aim: To detennine whether repetitive ann work, with a large component of static muscle contraction alters glucose metabolism and insulin sensitivity. Methad: Euglycemic clamps (2h) were started in ten healthy individuals 15 minutes after 37 minute periods of: 1) repetitive ann work in a simulated occupational setting; 2) dynamic concentric exercise on a cycle ergometer at 60% OfVO2 max and 3) a resting regime as a control. During the experimental periods, blood samples were collected, blood pressure was measured repeatedly and electrocardiogram (ECG) wasrecorded continuously. During the clamps, euglycemia was maintained at 5 mmo1/l and insulin was infused at 56 mU/m2/min for 120 min. Results: The insulin-mediated glucose disposal rate (M-value) for the steady state period (60- 120 min) of the clamp, tended to be lower following ann work than for both cycling and resting regimes. When dividing the steady state period into 20-minute intervals, the insulin sensitivity index, (ISI) was significantly lower for ann work compared with the resting control situation between 60-80 minutes (p=0.04) and 80-100 minutes (p=0.01) respectively. Catecholamines increased significantly for ann work and cycling compared with resting regime. .Data from heart rate variability (HRV) me asurements indicated significant sympathetic activation during repetitive ann work test. Canelusian: The results indicate that repetitive ann work might acutely promote insulin resistance, whereas no such effect on insulin resistance was produced by dynamic concentric exercise.

Nyckelord

Adult

Arm

Blood Glucose analysis

Blood Pressure physiology

Epinephrine blood

Ergometry methods

Exercise physiology

Fatty Acids

Nonesterified blood

Glucose metabolism

Heart Rate physiology

Humans

Hydrocortisone blood

Insulin blood metabolism

Insulin Resistancephysiology

Interleukin-6 blood

Lactates blood

Leptin blood

Male

Muscle Contraction physiology

Muscle

Skeletal physiology

Norepinephrine blood

Tumor Necrosis Factor-alpha analysis

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