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Association of anth...
Association of anthropometry and weight change with risk of dementia and its major subtypes: a meta-analysis consisting 2.8 million adults with 57,294 cases of dementia
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Lee, Crystal (author)
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Woodward, Mark (author)
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Batty, David (author)
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show more...
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Beiser, Alexa (author)
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Bell, Steven (author)
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Berr, Claudine (author)
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Bjertness, Espen (author)
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Chalmers, John (author)
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Clarke, Robert (author)
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Dartigues, Jean- Francois (author)
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Davis-Plourde, Kendra (author)
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Debette, Stéphanie (author)
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Di Angelantonio, Emanuele (author)
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Feart, Catherine (author)
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Frikke-Schmidt, Ruth (author)
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Gregson, John (author)
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Haan, Mary (author)
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- Hassing, Linda, 1967 (author)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Psykologiska institutionen,Centre for Ageing and Health (Agecap),Department of Psychology
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Hayden, Kathleen (author)
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Hoevenaar-Blom, Marieke (author)
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Kaprio, Jaakko (author)
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Kivimaki, Mika (author)
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- Lappas, Georgios (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Larson, Eric (author)
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LeBlanc, Erin (author)
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- 2020-01-03
- 2020
- English.
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In: Obesity Reviews. - : Wiley. - 1467-7881 .- 1467-789X. ; 21:4
- Related links:
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https://onlinelibrar...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Uncertainty exists regarding the relation of body size and weight change with dementia risk. As populations continue to age and the global obesity epidemic shows no sign of waning, reliable quantification of such associations is important. We examined the relationship of body mass index, waist circumference, and annual percent weight change with risk of dementia and its subtypes by pooling data from 19 prospective cohort studies and four clinical trials using meta-analysis. Compared with body mass index-defined lower-normal weight (18.5–22.4 kg/m2), the risk of all-cause dementia was higher among underweight individuals but lower among those with upper-normal (22.5–24.9 kg/m2) levels. Obesity was associated with higher risk in vascular dementia. Similarly, relative to the lowest fifth of waist circumference, those in the highest fifth had non-significant higher vascular dementia risk. Weight loss was associated with higher all-cause dementia risk relative to weight maintenance. Weight gain was weakly associated with higher vascular dementia risk. The relationship between body size, weight change and dementia is complex and exhibits nonlinear associations depending on dementia subtype under scrutiny. Weight loss was associated with an elevated risk most likely due to reverse causality and/or pathophysiological changes in the brain, although the latter remains speculative.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Lee, Crystal
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Woodward, Mark
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Batty, David
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Beiser, Alexa
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Bell, Steven
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Berr, Claudine
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show more...
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Bjertness, Espen
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Chalmers, John
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Clarke, Robert
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Dartigues, Jean- ...
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Davis-Plourde, K ...
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Debette, Stéphan ...
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Di Angelantonio, ...
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Feart, Catherine
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Frikke-Schmidt, ...
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Gregson, John
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Haan, Mary
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Hassing, Linda, ...
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Hayden, Kathleen
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Hoevenaar-Blom, ...
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Kaprio, Jaakko
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Kivimaki, Mika
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Lappas, Georgios
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Larson, Eric
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LeBlanc, Erin
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Rosengren, Annik ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Obesity Reviews
- By the university
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University of Gothenburg