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- OrthGomer, K, et al.
(författare)
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Lipoprotein(a) as a determinant of coronary heart disease in young women
- 1997
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Ingår i: Circulation. - NATL INST PSYCHOSOC FACTORS & HLTH,HUDDINGE,SWEDEN. DEACONESS HOSP,INST PREVENT CARDIOVASC DIS,BOSTON,MA. HARVARD UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL,BOSTON,MA 02115. KAROLINSKA HOSP,DEPT CARDIOL,S-10401 STOCKHOLM,SWEDEN. KAROLINSKA HOSP,DEPT THORAC RADIOL,S-10401 STOCKHOLM,SWEDEN. UNIV TEXAS,DIV CARDIOL,HOUSTON,TX. : AMER HEART ASSOC. - 0009-7322 .- 1524-4539. ; 95:2, s. 329-334
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Tidskriftsartikel (refereegranskat)abstract
- Background Lipoprotein(a) [Lp(a)] appears to be a risk factor for coronary heart disease (CHD) in men. The role of Lp(a) in women, however, is less clear. Methods and Results We examined the ability of Lp(a) to predict CHD in a population-based case-control study of women 65 years of age or younger who lived in the greater Stockholm area. Subjects were all patients hospitalized for an acute CHD event between February 1991 and February 1994. Control subjects were randomly selected from the city census and were matched to patients by age and catchment area. Lp(a) was measured 3 months after hospitalization by use of an immunoturbidometric method (Incstar) calibrated to the Northwest Lipid Research Laboratories (coefficient of variation was <9%). Of the 292 consecutive patients, 110 (37%) were hospitalized for an acute myocardial infarction, and 182 were hospitalized (63%) for angina pectoris. The mean age for both patients and control subjects was 56+/-7 years. Of participants, 74 patients (25%) and 84 control subjects (29%) were premenopausal. The distributions of Lp(a) were highly skewed in both patients and control subjects, with a range from 0.001 to 1.14 g/L. Age-adjusted odds ratio for CHD in the highest versus the lowest quartile of Lp(a) was 2.3 (95% confidence interval [CI], 1.4 to 3.7). After adjustment for age, smoking, education, body mass index, systolic blood pressure, total cholesterol, triglycerides, and HDL, the odds ratio was 2.9 (95% CI, 1.6 to 5.0). The odds ratios were similar when myocardial infarction and angina patients were compared with their respective control subjects. The odds ratios were 5.1 (95% CI, 1.4 to 18.4) and 2.4 (95% CI, 1.3 to 4.5) in premenopausal and postmenopausal women, respectively. Conclusions These results suggest that Lp(a) is a determinant of CHD in both premenopausal and postmenopausal women.
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- Belkic, D, et al.
(författare)
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Derivative NMR spectroscopy for J-coupled multiplet resonances using short time signals (0.5 KB) encoded at low magnetic field strengths (1.5T). Part I: water suppressed
- 2021
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Ingår i: JOURNAL OF MATHEMATICAL CHEMISTRY. - : Springer Science and Business Media LLC. - 0259-9791 .- 1572-8897. ; 59:2, s. 364-404
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The theme of this study is within the realm of basic nuclear magnetic resonance (NMR) spectroscopy. It relies upon the mathematics of signal processing for NMR in analytical chemistry and medical diagnostics. Our objective is to use the fast Padé transform (both derivative and nonderivative as well as parametric and nonparametric) to address the problem of multiplets from J-coupling appearing in total shape spectra as completely unresolved resonances. The challenge is exacerbated especially for short time signals (0.5 KB, no zero filling), encoded at a standard clinical scanner with the lowest magnetic field strengths (1.5T), as is the case in the present investigation. Water has partially been suppressed in the course of encoding. Nevertheless, the residual water content is still more than four times larger than the largest among the other resonances. This challenge is further sharpened by the following question: Can the J-coupled multiplets be resolved by an exclusive reliance upon shape estimation alone (nonparametric signal processing)? In this work, the mentioned parametric signal processing is employed only as a gold standard aimed at cross-validating the reconstructions from nonparametric estimations. A paradigm shift, the derivative NMR spectroscopy, is at play here through unprecedentedly parametrizing total shape spectra (i.e. solving the quantification problem) by sole shape estimators without fitting any envelope.
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| 7. |
- Belkic, D, et al.
(författare)
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Derivative NMR Spectroscopy for J-Coupled Multiplet Resonances using Short Time Signals (0.5KB) Encoded at Low Magnetic Field Strengths (1.5T). Part II: Water Unsuppressed
- 2021
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Ingår i: JOURNAL OF MATHEMATICAL CHEMISTRY. - : Springer Science and Business Media LLC. - 0259-9791 .- 1572-8897. ; 59:2, s. 405-443
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The topic of this work is on reliable resolving of J-coupled resonances in spectral envelopes from proton nuclear magnetic resonance (NMR) spectroscopy. These resonances appear as multiplets that none of the conventional nonderivative shape estimators can disentangle. However, the recently formulated nonconventional shape estimator, the derivative fast Padé transform (dFPT), has a chance to meet this challenge. In the preceding article with a polyethylene phantom, using the time signals encoded with water suppressed, the nonparametric dFPT was shown to be able to split apart the compound resonances that contain the known J-coupled multiplets. In the present work, we address the same proton NMR theme, but with sharply different initial conditions from encodings. The goal within the nonparametric dFPT is again to accurately resolve the J-coupled resonances with the same polyethylene phantom, but using raw time signals encoded without water suppression. The parallel work on the same problem employing two startlingly unequal time signals, encoded with and without water suppression in the preceding and the current articles, respectively, can offer an answer to a question of utmost practical significance. How much does water suppression during encoding time signals actually perturb the resonances near and farther away from the dominant water peak? This is why it is important to apply the same dFPT estimator to the time signals encoded without water suppression to complement the findings with water suppression. A notable practical side of this inquiry is in challenging the common wisdom, which invariably takes for granted that it is absolutely necessary to subtract water from the encoded time signals in order to extract meaningful information by way of NMR spectroscopy.
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