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Sökning: WFRF:(Belting Mattias) > Göteborgs universitet

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1.
  • Bratulic, Sinisa, 1981, et al. (författare)
  • Noninvasive detection of any-stage cancer using free glycosaminoglycans.
  • 2022
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:50
  • Tidskriftsartikel (refereegranskat)abstract
    • Cancer mortality is exacerbated by late-stage diagnosis. Liquid biopsies based on genomic biomarkers can noninvasively diagnose cancers. However, validation studies have reported ~10% sensitivity to detect stage I cancer in a screening population and specific types, such as brain or genitourinary tumors, remain undetectable. We investigated urine and plasma free glycosaminoglycan profiles (GAGomes) as tumor metabolism biomarkers for multi-cancer early detection (MCED) of 14 cancer types using 2,064 samples from 1,260 cancer or healthy subjects. We observed widespread cancer-specific changes in biofluidic GAGomes recapitulated in an in vivo cancer progression model. We developed three machine learning models based on urine (Nurine = 220 cancer vs. 360 healthy) and plasma (Nplasma = 517 vs. 425) GAGomes that can detect any cancer with an area under the receiver operating characteristic curve of 0.83-0.93 with up to 62% sensitivity to stage I disease at 95% specificity. Undetected patients had a 39 to 50% lower risk of death. GAGomes predicted the putative cancer location with 89% accuracy. In a validation study on a screening-like population requiring ≥ 99% specificity, combined GAGomes predicted any cancer type with poor prognosis within 18 months with 43% sensitivity (21% in stage I; N = 121 and 49 cases). Overall, GAGomes appeared to be powerful MCED metabolic biomarkers, potentially doubling the number of stage I cancers detectable using genomic biomarkers.
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2.
  • Kim, Dae-Kyum, et al. (författare)
  • EVpedia: A Community Web Portal for Extracellular Vesicles Research
  • 2015
  • Ingår i: Bioinformatics. - : Oxford University Press (OUP). - 1367-4803 .- 1367-4811. ; 31:6, s. 933-939
  • Tidskriftsartikel (refereegranskat)abstract
    • Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging. Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research.
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  • Resultat 1-2 av 2
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refereegranskat (2)
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Belting, Mattias (2)
Edqvist, Per-Henrik ... (1)
Enblad, Gunilla (1)
Höglund, Martin (1)
Nyman, Jan, 1956 (1)
Royo, Felix (1)
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Dabestani, Saeed (1)
Kjölhede, Henrik, 19 ... (1)
Häggman, Michael (1)
Lötvall, Jan, 1956 (1)
Wai, Sun Nyunt (1)
Hesselager, Göran (1)
Levin, Max, 1969 (1)
Stålberg, Karin (1)
Lindman, Henrik (1)
Lundstam, Sven, 1944 (1)
Simonson, Oscar (1)
Stierner, Ulrika, 19 ... (1)
Valadi, Hadi, 1963 (1)
Ekstrand, Matias (1)
Nielsen, Jens (1)
Stålberg, Peter (1)
Birgisson, Helgi (1)
Bergman, Bengt, 1953 (1)
Lässer, Cecilia, 198 ... (1)
Mandel Clausen, Thom ... (1)
Daugaard, Mads (1)
Salanti, Ali (1)
Pellegrino, Francesc ... (1)
Cocucci, Emanuele (1)
Jang, Su Chul, 1984 (1)
Park, Kyong-Su (1)
Marcilla, Antonio (1)
Siljander, Pia (1)
Bång-Rudenstam, Anna (1)
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Salonia, Andrea (1)
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Bratulic, Sinisa, 19 ... (1)
Limeta, Angelo, 1996 (1)
Gatto, Francesco, 19 ... (1)
Kumar, Gunjan (1)
Cavarretta, Ilaria (1)
Alfano, Massimo (1)
Maccari, Francesca (1)
Galeotti, Fabio (1)
Volpi, Nicola (1)
Gardiner, Chris (1)
Clayton, Aled (1)
Cheng, Lesley (1)
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Göteborgs universitet  (2)Ta bort avgränsningen
Lunds universitet (2)
Umeå universitet (1)
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Karolinska Institutet (1)
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