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- Hedsten, Karin, 1964, et al.
(författare)
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Downscaling Optical Biosensing System
- 2008
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Ingår i: Proceedings of Micro System Workshop 2008 (MSW08) 6-7 Maj, Göteborg, Sweden. ; MSW08, s. S2-6, s. 205-
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Konferensbidrag (refereegranskat)
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- Hedsten, Karin, 1964, et al.
(författare)
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MEMS-based VCSEL beam steering using replicated polymer diffractive lens
- 2008
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Ingår i: Sensors and Actuators, A: Physical. - : Elsevier BV. - 0924-4247 .- 1873-3069. ; 142:1, s. 336-345
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Tidskriftsartikel (refereegranskat)abstract
- Abstract. This paper describes a fully integrated micro-optical system, in which dynamic angular control of the beam from a VCSEL (vertical cavity surface emitting laser) is realized by laterally moving a collimat¬ing diffractive lens in the light path. The lens is mounted on a translatable silicon stage, which consists of a frame with an opening for the light to traverse the lens and electro-statically driven comb actuators, by which the lateral movement is achieved. Devices implementing both 1D and 2D scanning have been fabricated and evaluated. Integration of the lens onto the translatable silicon stage is done using a newly developed fabrication process based on hot embossing of an amorphous fluorocarbon polymer. This fabrication process relies on a reversed-order protocol, where the structuring of the optical element precedes the silicon microstructuring. Assembly and packaging of the VCSEL-MOEMS system, using LTCC (low temperature cofired ceramic) technique, is also demonstrated. Optical evaluation of the system and beam steering function shows significant beam deflection for a relatively low driving voltage (~70 V).
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- Hedsten, Karin, 1964, et al.
(författare)
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Optical Label-Free Nanoplasmonic Biosensing Using a Vertical-Cavity Surface-Emitting Laser and Charge-Coupled Device
- 2010
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 82:4, s. 1535-1539
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Tidskriftsartikel (refereegranskat)abstract
- We present a compact platform for biochemosensing based on the combination of a vertical-cavity surface- emitting laser (VCSEL) light source, microelectrome- chanical systems (MEMS)-based microoptics, a specially designed nanoplasmonic sensing chip, and charge- coupled device (CCD) detector. The platform does not require any spectral analyzer for signal evaluation, show- ing good promise for facile integration, neither does it use any microscope setup for the signal collection or imaging. The analytical capabilities of the developed biochemosens- ing platform are demonstrated by evaluation of the protein-substrate (biotinylated bovine serum albumin- gold) and the protein-protein (biotin-NeutrAvidin) bind- ing kinetics, which is further compared to detection based on conventional optical extinction spectroscopy. The instrument is able to detect low femtomoles of adsorbed proteins with the limit of detection comparable to the state-of-the-art research and commercial optical label-free biochemosensors.
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