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1.
  • Jiang, Xia, et al. (författare)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • Ingår i: Nature Communications. - 2041-1723. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. © 2019, The Author(s).
2.
  • Aad, G., et al. (författare)
  • Evidence for the spin-0 nature of the Higgs boson using ATLAS data
  • 2013
  • Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - Elsevier. - 0370-2693. ; 726:1-3, s. 120-144
  • Tidskriftsartikel (refereegranskat)abstract
    • Studies of the spin and parity quantum numbers of the Higgs boson are presented, based on protonproton collision data collected by the ATLAS experiment at the LHC. The Standard Model spin-parity J(P) = 0(+) hypothesis is compared with alternative hypotheses using the Higgs boson decays H -> gamma gamma, H -> ZZ* -> 4l and H -> WW* -> l nu l nu, as well as the combination of these channels. The analysed dataset corresponds to an integrated luminosity of 20.7 fb(-1) collected at a centre-of-mass energy of root s = 8 TeV. For the H -> ZZ* -> 4l decay mode the dataset corresponding to an integrated luminosity of 4.6 fb(-1) collected at root s = 7 TeV is included. The data are compatible with the Standard Model J(P) = 0+ quantum numbers for the Higgs boson, whereas all alternative hypotheses studied in this Letter, namely some specific J(P) = 0(-), 1(+), 1(-), 2(+) models, are excluded at confidence levels above 97.8%. This exclusion holds independently of the assumptions on the coupling strengths to the Standard Model particles and in the case of the J(P) = 2(+) model, of the relative fractions of gluon-fusion and quark-antiquark production of the spin-2 particle. The data thus provide evidence for the spin-0 nature of the Higgs boson, with positive parity being strongly preferred. (C) 2013 CERN. Published by Elsevier B.V. All rights reserved.
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3.
  • Aad, G., et al. (författare)
  • Measurement of differential J/psi production cross sections and forward-backward ratios in p plus Pb collisions with the ATLAS detector
  • 2015
  • Ingår i: Physical Review C (Nuclear Physics). - American Physical Society. - 0556-2813. ; 92:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Measurements of differential cross sections for J/psi production in p + Pb collisions at root S-NN= 5.02 TeV at the CERN Large Hadron Collider with the ATLAS detector are presented. The data set used corresponds to an integrated luminosity of 28.1 nb(-1). The J/psi mesons are reconstructed in the dimuon decay channel over the transverse momentum range 8 < PT < 30 GeV and over the center-of-mass rapidity range -2.87 < y* < 1.94. Prompt J/psi are separated from J/psi resulting from b-hadron decays through an analysis of the distance between the J/psi decay vertex and the event primary vertex. The differential cross section for production of nonprompt J/psi is compared to a FONLL calculation that does not include nuclear effects. Forward-backward production ratios are presented and compared to theoretical predictions. These results complement previously published results by covering a region of higher transverse momentum and more central rapidity. They thus constrain the kinematic dependence of nuclear modifications of charmonium and b-quark production in p + Pb collisions.
4.
  • Aad, G., et al. (författare)
  • Search for heavy Majorana neutrinos with the ATLAS detector in pp collisions at root s=8 TeV
  • 2015
  • Ingår i: Journal of High Energy Physics. - Springer. - 1029-8479. ; :7
  • Tidskriftsartikel (refereegranskat)abstract
    • A search for heavy Majorana neutrinos in events containing a pair of high-p(T) leptons of the same charge and high-p(T) jets is presented. The search uses 20.3 fb(-1) of pp collision data collected with the ATLAS detector at the CERN Large Hadron Collider with a centre-of-mass energy of root s = 8TeV. The data are found to be consistent with the background-only hypothesis based on the Standard Model expectation. In the context of a Type-I seesaw mechanism, limits are set on the production cross-section times branching ratio for production of heavy Majorana neutrinos in the mass range between 100 and 500 GeV. The limits are subsequently interpreted as limits on the mixing between the heavy Majorana neutrinos and the Standard Model neutrinos. In the context of a left-right symmetric model, limits on the production cross-section times branching ratio are set with respect to the masses of heavy Majorana neutrinos and heavy gauge bosons W-R and Z'.
5.
  • Aad, G., et al. (författare)
  • Search for new phenomena in photon plus jet events collected in proton-proton collisions at root s=8 TeV with the ATLAS detector
  • 2014
  • Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - Elsevier. - 0370-2693. ; 728, s. 562-578
  • Tidskriftsartikel (refereegranskat)abstract
    • This Letter describes a model-independent search for the production of new resonances in photon + jet (gamma + jet) events using 20 fb(-1) of proton-proton LHC data recorded with the ATLAS detector at a centre-of-mass energy of root s = 8 TeV. The gamma + jet mass distribution is compared to a background model fit from data; no significant deviation from the background-only hypothesis is found. Limits are set at 95% credibility level on generic Gaussian-shaped signals and two benchmark phenomena beyond the Standard Model: non-thermal quantum black holes and excited quarks. Non-thermal quantum black holes are excluded below masses of 4.6 TeV and excited quarks are excluded below masses of 3.5 TeV. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
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6.
  • Aad, G., et al. (författare)
  • A search for t(t)over-bar resonances using lepton-plus-jets events in proton-proton collisions at root s=8 TeV with the ATLAS detector
  • 2015
  • Ingår i: Journal of High Energy Physics. - Springer. - 1029-8479. ; :8
  • Tidskriftsartikel (refereegranskat)abstract
    • A search for new particles that decay into top quark pairs is reported. The search is performed with the ATLAS experiment at the LHC using an integrated luminosity of 20.3 fb(-1) of proton-proton collision data collected at a centre-of-mass energy of root s = 8TeV. The lepton-plus-jets final state is used, where the top pair decays to W (+) bW(-)(b) over bar, with one W boson decaying leptonically and the other hadronically. The invariant mass spectrum of top quark pairs is examined for local excesses or deficits that are inconsistent with the Standard Model predictions. No evidence for a top quark pair resonance is found, and 95% confidence-level limits on the production rate are determined for massive states in benchmark models. The upper limits on the cross-section times branching ratio of a narrow Z' boson decaying to top pairs range from 4.2 pb to 0.03 pb for resonance masses from 0.4 TeV to 3.0 TeV. A narrow leptophobic topcolour Z' boson with mass below 1.8 TeV is excluded. Upper limits are set on the cross-section times branching ratio for a broad colour-octet resonance with Gamma/m = 15% decaying to tt. These range from 4.8 pb to 0.03 pb for masses from 0.4 TeV to 3.0 TeV. A Kaluza-Klein excitation of the gluon in a Randall-Sundrum model is excluded for masses below 2.2 TeV.
7.
  • Aad, G, et al. (författare)
  • ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider.
  • 2015
  • Ingår i: European Physical Journal C. Particles and Fields. - Springer. - 1434-6044. ; 75:10
  • Tidskriftsartikel (refereegranskat)abstract
    • This paper reviews and extends searches for the direct pair production of the scalar supersymmetric partners of the top and bottom quarks in proton-proton collisions collected by the ATLAS collaboration during the LHC Run 1. Most of the analyses use 20 [Formula: see text] of collisions at a centre-of-mass energy of [Formula: see text] TeV, although in some case an additional [Formula: see text] of collision data at [Formula: see text] TeV are used. New analyses are introduced to improve the sensitivity to specific regions of the model parameter space. Since no evidence of third-generation squarks is found, exclusion limits are derived by combining several analyses and are presented in both a simplified model framework, assuming simple decay chains, as well as within the context of more elaborate phenomenological supersymmetric models.
8.
  • Aad, G, et al. (författare)
  • Determination of the Ratio of b-Quark Fragmentation Fractions f_{s}/f_{d} in pp Collisions at sqrt[s]=7 TeV with the ATLAS Detector.
  • 2015
  • Ingår i: Physical Review Letters. - American Physical Society. - 1079-7114. ; 115:26
  • Tidskriftsartikel (refereegranskat)abstract
    • With an integrated luminosity of 2.47 fb^{-1} recorded by the ATLAS experiment at the LHC, the exclusive decays B_{s}^{0}→J/ψϕ and B_{d}^{0}→J/ψK^{*0} of B mesons produced in pp collisions at sqrt[s]=7 TeV are used to determine the ratio of fragmentation fractions f_{s}/f_{d}. From the observed B_{s}^{0}→J/ψϕ and B_{d}^{0}→J/ψK^{*0} yields, the quantity (f_{s}/f_{d})[B(B_{s}^{0}→J/ψϕ)/B(B_{d}^{0}→J/ψK^{*0})] is measured to be 0.199±0.004(stat)±0.008(syst). Using a recent theory prediction for [B(B_{s}^{0}→J/ψϕ)/B(B_{d}^{0}→J/ψK^{*0})] yields (f_{s}/f_{d})=0.240±0.004(stat)±0.010(syst)±0.017(th). This result is based on a new approach that provides a significant improvement of the world average.
9.
  • Aad, G., et al. (författare)
  • Determination of the top-quark pole mass using t(t)over-bar+1-jet events collected with the ATLAS experiment in 7 TeV pp collisions
  • 2015
  • Ingår i: Journal of High Energy Physics. - Springer. - 1029-8479. ; :10
  • Tidskriftsartikel (refereegranskat)abstract
    • The normalized differential cross section for top-quark pair production in association with at least one jet is studied as a function of the inverse of the invariant mass of the t (t) over bar + 1-jet system. This distribution can be used for a precise determination of the top-quark mass since gluon radiation depends on the mass of the quarks. The experimental analysis is based on proton-proton collision data collected by the ATLAS detector at the LHC with a centre-of-mass energy of 7TeV corresponding to an integrated luminosity of 4.6 fb(-1). The selected events were identified using the lepton+jets top-quark-pair decay channel, where lepton refers to either an electron or a muon. The observed distribution is compared to a theoretical prediction at next-to-leading-order accuracy in quantum chromodynamics using the pole-mass scheme. With this method, the measured value of the top-quark pole mass, m(t)(pole), is: m(t)(pole) t = 173.7 +/- 1.5 (stat.) +/- 1.4 (syst.)(-0.5)(+1.0) (theory) GeV. This result represents the most precise measurement of the top-quark pole mass to date.
10.
  • Aad, G., et al. (författare)
  • Measurement of charged-particle spectra in Pb plus Pb collisions at root s(NN)=2.76 TeV with the ATLAS detector at the LHC
  • 2015
  • Ingår i: Journal of High Energy Physics. - Springer. - 1029-8479. ; :9
  • Tidskriftsartikel (refereegranskat)abstract
    • Charged-particle spectra obtained in Pb+Pb interactions at root s(NN) = 2.76TeV and pp interactions at root s(NN) = 2.76TeV with the ATLAS detector at the LHC are presented, using data with integrated luminosities of 0.15 nb(-1) and 4.2 pb(-1), respectively, in a wide transverse momentum (0.5 < p(T) < 150 GeV) and pseudorapidity (vertical bar eta vertical bar < 2) range. For Pb+Pb collisions, the spectra are presented as a function of collision centrality, which is determined by the response of the forward calorimeters located on both sides of the interaction point. The nuclear modification factors R-AA and R-CP are presented in detail as a function of centrality, p(T) and eta. They show a distinct p(T)-dependence with a pronounced minimum at about 7 GeV. Above 60 GeV, R-AA is consistent with a plateau at a centrality-dependent value, within the uncertainties. The value is 0.55 +/- 0.01(stat.) +/- 0.04(syst.) in the most central collisions. The R-AA distribution is consistent with flat vertical bar eta vertical bar dependence over the whole transverse momentum range in all centrality classes.
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