| 1. |
- Martel, I., et al.
(author)
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An innovative Superconducting Recoil Separator for HIE-ISOLDE
- 2023
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In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. - : ELSEVIER. - 0168-583X .- 1872-9584. ; 541, s. 176-179
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Journal article (peer-reviewed)abstract
- The ISOLDE Scientific Infrastructure at CERN offers a unique range of post-accelerated radioactive beams. The scientific program can be improved with the “Isolde Superconducting Recoil Separator” (ISRS), an innovative spectrometer able to deliver unprecedented (A, Z) resolution. In this paper we present an overview of the physics and ongoing technical developments.
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| 2. |
- Michel, M., et al.
(author)
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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
- 2022
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In: Science. - Stockholm : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 376:6600, s. 1471-1476
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Journal article (peer-reviewed)abstract
- Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed b,d-lyase enzymatic function. TH10785 controls the catalytic activity mediated by a nitrogen base within its molecular structure. In cells, TH10785 increases OGG1 recruitment to and repair of oxidative DNA damage. This alters the repair process, which no longer requires APE1 but instead is dependent on polynucleotide kinase phosphatase (PNKP1) activity. The increased repair of oxidative DNA lesions with a small molecule may have therapeutic applications in various diseases and aging. © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
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| 3. |
- Allaire, C., et al.
(author)
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Beam test measurements of Low Gain Avalanche Detector single pads and arrays for the ATLAS High Granularity Timing Detector
- 2018
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In: Journal of Instrumentation. - : Institute of Physics (IOP). - 1748-0221 .- 1748-0221. ; 13
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Journal article (peer-reviewed)abstract
- For the high luminosity upgrade of the LHC at CERN, ATLAS is considering the addition of a High Granularity Timing Detector (HGTD) in front of the end cap and forward calorimeters at vertical bar z vertical bar = 3:5 m and covering the region 2:4 < vertical bar eta vertical bar < 4 to help reducing the effect of pile-up. The chosen sensors are arrays of 50 mu m thin Low Gain Avalanche Detectors (LGAD). This paper presents results on single LGAD sensors with a surface area of 1.3 x 1.3 mm(2) and arrays with 2 x 2 pads with a surface area of 2 x 2 mm(2) or 3 x 3 mm(2) each and different implant doses of the p(+) multiplication layer. They are obtained from data collected during a beam test campaign in autumn 2016 with a pion beam of 120 GeV energy at the CERN SPS. In addition to several quantities measured inclusively for each pad, the gain, efficiency and time resolution have been estimated as a function of the position of the incident particle inside the pad by using a beam telescope with a position resolution of few mu m. Different methods to measure the time resolution are compared, yielding consistent results. The sensors with a surface area of 1.3 x 1.3 mm(2) have a time resolution of about 40 ps for a gain of 20 and of about 27 ps for a gain of 50 and fulfil the HGTD requirements. Larger sensors have, as expected, a degraded time resolution. All sensors show very good efficiency and time resolution uniformity.
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| 4. |
- Garcia, Ariel, et al.
(author)
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Chemical and physical characterization and acid hydrolysis of a mixture of Jatropha curcas shells and husks
- 2015
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In: Cellulose Chemistry and Technology. - : Editura Academiei Romane,Publishing House of the Romanian Academy. - 0576-9787. ; 49:9-10, s. 737-744
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Journal article (peer-reviewed)abstract
- Jatropha curcas L. is a tropical plant with considerable potential for producing biodiesel and other products of high economic and social interest. During the biodiesel production process from J. curcas different residues, such as shells and husks are generated. In this work, the physical characterization of J. curcas fruits was performed, and the chemical composition of a mixture of shells and husks was determined. The physical characterization revealed that shells and husks account, respectively, for 25.0 and 27.8% of the fruit weight. The compositional analyses of the material showed a rather high content of glucans (32.8% w/w) and xylans (16.4% w/w), which indicates the potential of J. curcas shells and husks for production of ethanol, xylitol and other glucose- and xylose-derived products. Acid hydrolysis was applied to a mixture of shells and husks under different sulphuric acid concentrations (from 0.5 to 4.5%), temperatures (170 – 220ºC) and time (10 – 20 min), and the hydrolytic conversion of xylan was evaluated. A zone of experimental conditions giving maximal xylan conversion was identified at around 4% H2SO4, 180ºC and reaction time below 10 min.
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| 5. |
- Hernández-Maldonado, Luz M, et al.
(author)
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In Vitro Gastrointestinal Digestion and Colonic Fermentation of High Dietary Fiber and Antioxidant-Rich Mango (Mangifera indica L.) "Ataulfo"-Based Fruit Bars
- 2019
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 11:7
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Journal article (peer-reviewed)abstract
- Mango (Mangifera indica L.) is a tropical fruit which is considered to be a source of dietary fiber (DF) and phenolic compounds (PCs). In this study, high DF mango-based fruit bars were developed from whole mango (peel and pulp). The bars were evaluated for their nutritional composition, the bioaccesibility of PCs during gastrointestinal digestion, and the PCs metabolites profile after in vitro colonic fermentation. The amount of DF in a 30 g portion of mango bars was 9.5 g, i.e., 35% of the recommended daily intake. Phenolic acids such as gallic acid; cinnamic acids, such as ferulic, coumaric, and caffeic acids; flavonoids such as quercertin; and xanthones such as mangiferin and mangiferin gallate, were identified as the main PCs in the bars. The antioxidant capacity associated with the PCs profile, together with the high DF content are indicative of the potential functional features of these natural fruit bars. The bioaccesibility of PCs in the mango bar was 53.78%. During fermentation, the PCs were bioconverted mainly to hydroxyphenolic acids and the main short-chain fatty acid produced was acetic acid. The xanthone norathyriol was identified after 12 h of fermentation. This study on the digestion and colonic fermentation of mango-based bars using in vitro models provides hints of the potential physiological behavior of PCs associated with DF, which constitutes relevant information for further development of natural and health-promoting fruit-based bars.
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| 6. |
- Olmos, R., et al.
(author)
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Anomalous emissions of SO2 during the recent eruption of Santa Ana volcano, El Salvador, Central America
- 2007
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In: Pure and Applied Geophysics. - : Springer Science and Business Media LLC. - 0033-4553 .- 1420-9136. ; 164:12, s. 2489-2506
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Journal article (peer-reviewed)abstract
- Santa Ana volcano in western El Salvador, Central America, had a phreatic eruption at 8:05 am (local time) on October 1, 2005, 101 years after its last eruption. However, during the last one hundred years this volcano has presented periods of quiet degassing with fumarolic activity and an acidic lake within its crater. This paper presents results of frequent measurements of SO2 degassing using the MiniDOAS (Differential Optical Absorption Spectroscopy) system and a comparison with the volcanic seismicity prior to the eruption, during, and after the eruption. Vehicle measurements of SO2 flux were taken every hour during the first nine days of the eruption and daily after that. The period of time reported here is from August to December, 2005. Three periods of degassing are distinguished: pre-eruptive, eruptive, and post-eruptive periods. The intense activity at Santa Ana volcano started in July 2005. During the pre-eruptive period up to 4306 and 5154 ton/day of SO2 flux were recorded on October 24 and September 9, 2005, respectively. These values were of the same order of magnitude as the recorded values just after the October 1(st) eruption (2925 ton/day at 10: 01 am). Hourly measurements of SO2 flux taken during the first nine days after the main eruptive event indicate that explosions are preceded by an increase in SO2 flux and that this parameter reaches a peak after the explosion took place. This behavior suggests that increasing accumulation of exsolved magmatic gases occurs within the magmatic chamber before the explosions, increasing the pressure until the point of explosion. A correlation between SO2 fluxes and RSAM (Real Time Seismic Amplitude Measurements) is observed during the complete sampling period. Periodic fluctuations in the SO2 and RSAM values during the entire study period are observed. One possible mechanism explaining these fluctuations it that convective circulation within the magmatic chamber can bring fresh magma periodically to shallow levels, allowing increasing degasification and then decreasing degasification as the batch of magma lowers its gas content, becomes denser, and sinks to give space to a new magma pulse. These results illustrate that the measurements of SO2 flux can provide important warning signals for incoming explosive activity in active volcanoes.
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