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> Magnusson Patrik K E >
Macrophage inhibito...
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) : a new marker of all-cause mortality
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- Wiklund, Fredrik E (author)
- Karolinska Institutet
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- Bennet, Anna M (author)
- Karolinska Institutet
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- Magnusson, Patrik K E (author)
- Karolinska Institutet
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Eriksson, Ulrika K (author)
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- Lindmark, Fredrik (author)
- Umeå universitet,Urologi och andrologi
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Wu, Liyun (author)
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Yaghoutyfam, Nasreen (author)
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Marquis, Christopher P (author)
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- Stattin, Pär (author)
- Umeå universitet,Urologi och andrologi
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- Pedersen, Nancy L (author)
- Karolinska Institutet
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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- Grönberg, Henrik (author)
- Karolinska Institutet
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Breit, Samuel N (author)
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Brown, David A (author)
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(creator_code:org_t)
- 2010-10-21
- 2010
- English.
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In: Aging Cell. - : Wiley. - 1474-9718 .- 1474-9726. ; 9:6, s. 1057-1064
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Abstract
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- Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the TGF-b superfamily, previously studied in cancer and inflammation. In addition to regulating body weight, MIC-1/GDF15 may be used to predict mortality and/or disease course in cancer, cardiovascular disease (CVD), chronic renal and heart failure, as well as pulmonary embolism. These data suggested that MIC-1/GDF15 may be a marker of all-cause mortality. To determine whether serum MIC-1/GDF15 estimation is a predictor of all-cause mortality, we examined a cohort of 876 male subjects aged 35-80 years, selected from the Swedish Population Registry, and followed them for overall mortality. Serum MIC-1/GDF15 levels were determined for all subjects from samples taken at study entry. A second (independent) cohort of 324 same-sex twins (69% female) from the Swedish Twin Registry was similarly examined. All the twins had telomere length measured and 183 had serum levels of interleukin 6 (IL-6) and C-reactive protein (CRP) available. Patients were followed for up to 14 years and had cause-specific and all-cause mortality determined. Serum MIC-1/GDF15 levels predicted mortality in the all-male cohort with an adjusted odds ratio (OR) of death of 3.38 (95%CI 1.38-8.26). This finding was validated in the twin cohort. Serum MIC-1/GDF15 remained an independent predictor of mortality when further adjusted for telomere length, IL-6 and CRP. Additionally, serum MIC-1/GDF15 levels were directly correlated with survival time independently of genetic background. Serum MIC-1/GDF15 is a novel predictor of all-cause mortality.
Keyword
- MIC-1/GDF15
- all-cause mortality
- serum marker
- cytokine
- prospective observational cohort
- environmental toxicity
Publication and Content Type
- ref (subject category)
- art (subject category)
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Aging Cell
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- By the author/editor
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Wiklund, Fredrik ...
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Bennet, Anna M
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Magnusson, Patri ...
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Eriksson, Ulrika ...
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Lindmark, Fredri ...
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Wu, Liyun
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show more...
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Yaghoutyfam, Nas ...
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Marquis, Christo ...
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Stattin, Pär
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Pedersen, Nancy ...
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Adami, Hans-Olov
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Grönberg, Henrik
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Breit, Samuel N
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Brown, David A
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show less...
- Articles in the publication
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Aging Cell
- By the university
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Umeå University
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Karolinska Institutet