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> Bengtsson Nils Olof >
Incidence of heart ...
Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden
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McGale, Paul (author)
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Darby, Sarah C. (author)
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- Hall, Per (author)
- Karolinska Institutet
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- Adolfsson, Jan (author)
- Karolinska Institutet
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- Bengtsson, Nils-Olof (author)
- Umeå universitet,Onkologi
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- Bennet, Anna M. (author)
- Karolinska Institutet
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- Fornander, Tommy (author)
- Karolinska Institutet
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- Gigante, Bruna (author)
- Karolinska Institutet
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Jensen, Maj-Britt (author)
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Peto, Richard (author)
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Rahimi, Kazem (author)
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Taylor, Carolyn W. (author)
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Ewertz, Marianne (author)
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(creator_code:org_t)
- Amsterdam : Elsevier, 2011
- 2011
- English.
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In: Radiotherapy and Oncology. - Amsterdam : Elsevier. - 0167-8140 .- 1879-0887. ; 100:2, s. 167-175
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose: To study incidence of radiation-related heart disease in a large population of breast cancer patients followed for up to 30 years. Material and methods: 72,134 women diagnosed with breast cancer in Denmark or Sweden during 1976-2006 and followed prospectively. Radiation-related risk was studied by comparing women with left-sided and right-sided tumours. Results: 34,825 women (48%) received radiotherapy. Among unirradiated women tumour laterality had little relevance to heart disease. Among irradiated women mean dose to the whole heart was 6.3 Gy for left-sided tumours and 2.7 Gy for right-sided tumours. Mortality was similar in irradiated women with left-sided and right-sided tumours, but incidence ratios, left-sided versus right-sided, were raised: acute myocardial infarction 1.22 (95% CI 1.06-1.42), angina 1.25 (1.05-1.49), pericarditis 1.61 (1.06-2.43), valvular heart disease 1.54 (1.11-2.13). Incidence ratios for all heart disease were as high for women irradiated since 1990 (1.09 [1.00-1.19]) as for women irradiated during 1976-1989 (1.08 [0.99-1.17]), and were higher for women diagnosed with ischaemic heart disease prior to breast cancer than for other women (1.58 [1.19-2.10] versus 1.08 [1.01-1.15], p for difference = 0.01). Conclusions: Breast cancer radiotherapy has, at least until recently, increased the risk of developing ischaemic heart disease, pericarditis and valvular disease. Women with ischaemic heart disease before breast cancer diagnosis may have incurred higher risks than others. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 100 (2011) 167-175
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Breast cancer
- Radiotherapy
- Heart disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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McGale, Paul
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Darby, Sarah C.
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Hall, Per
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Adolfsson, Jan
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Bengtsson, Nils- ...
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Bennet, Anna M.
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show more...
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Fornander, Tommy
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Gigante, Bruna
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Jensen, Maj-Brit ...
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Peto, Richard
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Rahimi, Kazem
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Taylor, Carolyn ...
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Ewertz, Marianne
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Radiotherapy and ...
- By the university
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Umeå University
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Karolinska Institutet