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Träfflista för sökning "WFRF:(Bentley D) "

Search: WFRF:(Bentley D)

  • Result 1-10 of 139
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1.
  • Niemi, MEK, et al. (author)
  • 2021
  • swepub:Mat__t
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  • Kanai, M, et al. (author)
  • 2023
  • swepub:Mat__t
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  • Ramdas, S., et al. (author)
  • A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
  • 2022
  • In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 109:8, s. 1366-1387
  • Journal article (peer-reviewed)abstract
    • A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
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10.
  • Akkoyun, S., et al. (author)
  • AGATA - Advanced GAmma Tracking Array
  • 2012
  • In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 0167-5087 .- 1872-9576. ; 668, s. 26-58
  • Journal article (peer-reviewed)abstract
    • The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation γ-ray spectrometer. AGATA is based on the technique of γ-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a γ ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of γ-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector- response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. © 2011 Elsevier B.V. All rights reserved.
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  • Result 1-10 of 139
Type of publication
journal article (118)
conference paper (14)
research review (5)
Type of content
peer-reviewed (129)
other academic/artistic (8)
Author/Editor
Bentley, M.A. (42)
Rudolph, Dirk (31)
Gerl, J. (22)
Fahlander, Claes (21)
Gorska, M. (20)
Kojouharov, I. (19)
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Schaffner, H. (19)
Kurz, N (18)
Pietri, S. (18)
Simpson, J (17)
Wieland, O. (17)
Bednarczyk, P. (16)
Jungclaus, A. (16)
Reiter, P. (16)
Wollersheim, H.J. (16)
Blazhev, A. (15)
Seweryniak, D. (15)
Grebosz, J. (14)
Camera, F. (13)
Fallon, P (12)
Johansson, Emma (12)
Doornenbal, P. (12)
Podolyak, Zs. (12)
Ekman, Jörgen (11)
Campbell, A (11)
de Angelis, G. (11)
Benzoni, G. (11)
Lenzi, S.M. (11)
Regan, P. H. (11)
Wadsworth, R. (11)
Prokopowicz, W. (11)
Hoischen, Robert (11)
Becker, F. (11)
Yang, J. (10)
Boutachkov, P. (10)
Gadea, A. (10)
Maj, A. (10)
Pietralla, N. (10)
Johnson, R (9)
Zhao, W. (9)
Gudnason, V (9)
Franks, Paul W. (9)
Ameil, F. (9)
Balabanski, D.L. (9)
Gottardo, A. (9)
Habermann, T. (9)
Merchan, E. (9)
Rudolph, D. (9)
Grawe, H. (9)
Carpenter, M P (9)
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University
Lund University (82)
Uppsala University (38)
Karolinska Institutet (32)
Royal Institute of Technology (20)
Umeå University (10)
Chalmers University of Technology (8)
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University of Gothenburg (6)
Stockholm University (6)
Linköping University (3)
Örebro University (2)
Malmö University (2)
Luleå University of Technology (1)
Stockholm School of Economics (1)
Mid Sweden University (1)
Linnaeus University (1)
University of Borås (1)
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Language
English (139)
Research subject (UKÄ/SCB)
Natural sciences (86)
Medical and Health Sciences (32)
Engineering and Technology (5)

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