Circulating survivin indicates severe course of juvenile idiopathic arthritis.

• BACKGROUND: Survivin is an anti-apoptotic protein that has been recently suggested as a predictive marker of joint destruction in adult rheumatoid arthritis. We assessed the presence of extracellular survivin in patients with juvenile idiopathic arthritis (JIA). METHODS: Survivin levels were assessed in the circulation of 46 patients with JIA and in the age- and gender-matched controls (n=46) having no inflammatory disease, by ELISA. Survivin levels were analyzed with respect to the onset type and the activity of the joint disease. The intensity of inflammation and cartilage turnover was measured as levels of IL-6, serum amyloid A protein (SAA), and cartilage oligomeric matrix protein (COMP), respectively. RESULTS: The levels of extracellular survivin were significantly higher in JIA compared to the controls (p=0.0002). High levels of survivin (above mean + 2SD of the controls) were detected in 8/46 (17% JIA patients. High survivin expression was associated with polyarticular onset, active phase of arthritis. In contrast, survivin was neither related to the levels of IL-6, SAA, nor to COMP. CONCLUSION: Circulating survivin is expressed in a significant group of patients with JIA being associated to a severe course of the disease. It may be potentially used to select children with unfavorable prognosis of JIA who are in need of active pharmacologic treatment.

Nyckelord

Adolescent

Arthritis

Juvenile Rheumatoid

diagnosis

metabolism

Biological Markers

blood

Child

Extracellular Matrix Proteins

blood

Extracellular Space

metabolism

Female

Glycoproteins

blood

Humans

Interleukin-6

blood

Male

Microtubule-Associated Proteins

blood

Neoplasm Proteins

blood

Predictive Value of Tests

Prognosis

Serum Amyloid A Protein

metabolism

Severity of Illness Index

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)