| 1. |
- Chagtai, Tasnim, et al.
(författare)
-
Gain of 1q as a prognostic biomarker in Wilms Tumors (WTs) treated with preoperative chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 trial : A SIOP renal tumours biology consortium study
- 2016
-
Ingår i: Journal of Clinical Oncology. - 0732-183X. ; 34:26, s. 3195-3203
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: Wilms tumor (WT) is the most common pediatric renal tumor. Treatment planning under International Society of Paediatric Oncology (SIOP) protocols is based on staging and histologic assessment of response to preoperative chemotherapy. Despite high overall survival (OS), many relapses occur in patients without specific risk factors, and many successfully treated patients are exposed to treatments with significant risks of late effects. To investigate whether molecular biomarkers could improve risk stratification, we assessed 1q status and other potential copy number biomarkers in a large WT series. Materials and Methods: WT nephrectomy samples from 586 SIOP WT 2001 patients were analyzed using a multiplex ligation-dependent probe amplification (MLPA) assay that measured the copy number of 1q and other regions of interest. Results: One hundred sixty-seven (28%) of 586 WTs had 1q gain. Five-year event-free survival (EFS) was 75.0% in patients with 1q gain (95% CI, 68.5% to 82.0%) and 88.2% in patients without gain (95% CI, 85.0% to 91.4%). OS was 88.4% with gain (95% CI, 83.5% to 93.6%) and 94.4% without gain (95% CI, 92.1% to 96.7%). In univariable analysis, 1q gain was associated with poorer EFS (P < .001; hazard ratio, 2.33) and OS (P = .01; hazard ratio, 2.16). The association of 1q gain with poorer EFS retained significance in multivariable analysis adjusted for 1p and 16q loss, sex, stage, age, and histologic risk group. Gain of 1q remained associated with poorer EFS in tumor subsets limited to either intermediate-risk localized disease or nonanaplastic localized disease. Other notable aberrations associated with poorer EFS included MYCN gain and TP53 loss. Conclusion: Gain of 1q is a potentially valuable prognostic biomarker in WT, in addition to histologic response to preoperative chemotherapy and tumor stage.
|
|
| 2. |
- Drobyshev, Igor, et al.
(författare)
-
Multi-century reconstruction of fire activity in Northern European boreal forest suggests differences in regional fire regimes and their sensitivity to climate
- 2014
-
Ingår i: Journal of Ecology. - : Wiley. - 0022-0477 .- 1365-2745. ; 102:3, s. 738-748
-
Tidskriftsartikel (refereegranskat)abstract
- Forest fires are one of the main disturbance agents in boreal and temperate ecosystems. To decipher large-scale temporal and spatial patterns of past fire activity in Scandinavia, we analysed the synchronicity of dendrochoronologically reconstructed fire events in a large network of sites (n=62; 3296 samples, 392 individual fire years) covering a wide geographical gradient (56.5-67.0 degrees N and 9.3-20.5 degrees E) over AD 1400-1900. We identified large fire years (LFY) as years with regionally increased forest fire activity and located the geographical centres of climatic anomalies associated with synchronous LFY occurrence across the region, termed LFY centroids. The spatial pattern of LFY centroids indicated the presence of two regions with climatically mediated synchronicity of fire occurrence, located south and north from 60 degrees N. The return intervals of LFYs in Scandinavia followed a Weibull distribution in both regions. Intervals, however, differed: a period of 40years would carry a 0.93 probability of LFY occurrence in the southern region, but only a 0.48 probability of LFY occurrence in the northern region. Over 1420-1759, the northern region was characterized by significantly higher temporal variability in LFY occurrence than the southern region. Temporal correlation of LFYs with reconstructed average summer temperature and total precipitation was evident mainly for the northern region. LFYs in this region were associated with positive temperature and negative precipitation anomalies over Scandinavia and with colder and wetter conditions in more southern parts of the European subcontinent. Synthesis. Historical patterns of the occurrence of large fire years (LFY) in Scandinavia point towards the presence of two well-defined zones with characteristic fire activity, with the geographical division at approximately 60 degrees N. The northern and mid-boreal forests, although exhibiting lower LFY frequencies, appeared to be more sensitive to past summer climate, as compared to the southern boreal forests. This would imply that fire regimes across Scandinavia may show an asynchronous response to future climate changes.
|
|
| 3. |
- Grosbois, Guillaume, et al.
(författare)
-
Land and Freshwater Complex Interactions in Boreal Forests: A Neglected Topic in Forest Management
- 2023
-
Ingår i: Boreal Forests in the Face of Climate Change. - Cham : Springer International Publishing. - 9783031159879 - 9783031159886 - 9783031159909 ; 74, s. 719-745
-
Bokkapitel (refereegranskat)abstract
- Aquatic and terrestrial habitats are interdependent components of the boreal forest landscape involving multiple dynamic interactions; these are manifested particularly in riparian areas, which are key components in the forest landscape. However, this interdependence between aquatic and terrestrial habitats is not adequately accounted for in the current management of forest ecosystems. Here we review the impacts of land disturbances on the optical and physicochemical properties of water bodies, aquatic food web health, and the ecological functioning of these freshwaters. We also describe how freshwaters influence the adjacent terrestrial ecosystems. A better understanding of these dynamic biotic and abiotic interactions between land and freshwater of the boreal forest is a first step toward including these freshwaters in the sustainable management of the boreal forest.
|
|
