| 1. |
- Thysell, Elin, et al.
(författare)
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Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol
- 2010
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Ingår i: PLoS One. - : Public Library of Science. - 1932-6203. ; 5:12
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Tidskriftsartikel (refereegranskat)abstract
- Background: Metastasis to the bone is one clinically important features of prostate cancer (PCa). Current diagnostic methods cannot predict metastatic PCa at a curable stage of the disease. Identification of metabolic pathways involved in the growth of bone metastases therefore has the potential to improve PCa prognostication as well as therapy.Methodology/Principal Findings: Metabolomics was applied for the study of PCa bone metastases (n = 20) in comparison with corresponding normal bone (n = 14), and furthermore of malignant (n = 13) and benign (n = 17) prostate tissue and corresponding plasma samples obtained from patients with (n = 15) and without (n = 13) diagnosed metastases and from men with benign prostate disease (n = 30). This was done using gas chromatography-mass spectrometry for sample characterization, and chemometric bioinformatics for data analysis. Results were verified in a separate test set including metastatic and normal bone tissue from patients with other cancers (n = 7). Significant differences were found between PCa bone metastases, bone metastases of other cancers, and normal bone. Furthermore, we identified metabolites in primary tumor tissue and in plasma which were significantly associated with metastatic disease. Among the metabolites in PCa bone metastases especially cholesterol was noted. In a test set the mean cholesterol level in PCa bone metastases was 127.30 mg/g as compared to 81.06 and 35.85 mg/g in bone metastases of different origin and normal bone, respectively (P = 0.0002 and 0.001). Immunohistochemical staining of PCa bone metastases showed intense staining of the low density lipoprotein receptor and variable levels of the scavenger receptor class B type 1 and 3-hydroxy-3-methylglutaryl-coenzyme reductase in tumor epithelial cells, indicating possibilities for influx and de novo synthesis of cholesterol.Conclusions/Significance: We have identified metabolites associated with PCa metastasis and specifically identified high levels of cholesterol in PCa bone metastases. Based on our findings and the previous literature, this makes cholesterol a possible therapeutic target for advanced PCa.
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| 2. |
- Arevström, Lilith, et al.
(författare)
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Freeze-dried bilberry (Vaccinium myrtillus) dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial
- 2019
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Ingår i: Nutrition Research. - : Elsevier BV. - 0271-5317 .- 1879-0739. ; 62, s. 13-22
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Tidskriftsartikel (refereegranskat)abstract
- Vaccinium myrtillus, have a high content of phenolic compounds including anthocyanins, which could provide cardiometabolic health benefits following acute myocardial infarction (AMI). We hypothesized that standard medical therapy supplemented with freeze-dried bilberry after AMI would have a more beneficial effect on cardiovascular risk markers and exercise capacity than medical therapy alone. Patients were allocated in a 1:1 ratio within 24 hours of percutaneous coronary intervention in an 8- week trial either to V myrtillus powder (40 g/d, equivalent to 480 g fresh bilberries) and standard medical therapy or to a control group receiving standard medical therapy alone. High-sensitivity C-reactive protein and exercise capacity measured with the 6-minute walk test were the primary biochemical and clinical end points, respectively. Fifty subjects completed the study. No statistically significant difference in high-sensitivity C-reactive protein was detected between groups. The mean 6-minute walk test distance increased significantly more in the bilberry group compared to the control group: mean difference 38 m at follow-up (95% confidence interval 14- 62, P =.003). Ex vivo oxidized low-density lipoprotein was significantly lowered in the bilberry group compared to control, geometric mean ratio 0.80 (95% confidence interval 0.66-0.96, P =.017), whereas total cholesterol and low-density lipoprotein cholesterol did not differ significantly between groups. Anthocyanin-derived metabolites in blood increased significantly in the bilberry group during the intervention and were different after 8 weeks between the bilberry group and control. Findings in the present study suggest that bilberries may have clinically relevant beneficial effects following AMI; a larger, double-blind clinical trial is warranted to confirm this.
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| 3. |
- Johansson, Ulf, et al.
(författare)
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Är anpassning av skogsskötseln nödvändigt i dagsläget för att minska skogsskador i ett förändrat klimat?
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- En klimatförändring kommer att ändra förutsättningarna för de skogliga ekosystemen, vilketkommer sannolikt att kräva förändrade skogsbruks- och skötselmetoder. I denna rapport har vianalyserat tänkbara strategier för skogsbruket och sätta in dem i ett vidare perspektiv. Ensådan analys måste naturligtvis göras med stor ödmjukhet, eftersom kunskapsläget om vilkaeffekterna kan tänkas bli är dåligt och osäkerheterna kring alla relevanta prognoser är mycketstora.I den första delen av rapporten analyserar vi konsekvenserna av olika skogsskötselalternativpå beståndsnivå: (i) övergång till ett skogsbruk utan gallringar och med omloppstider kortareän de som idag tillämpas, (ii) en successiv övergång till ett lövskogsskogsbruk genom att efterslutavverkning alltid föryngra med löv var det andra alternativet och (iii) övergång tillhögproduktiva exotiska trädslag. De olika alternativen analyserades utifrån en beskrivenklimatförändring och utvärderades i termer av virkesproduktion, ekonomi och skaderisker.I den andra delen av rapporten försöker vi generalisera diskussionen till en regional nivå ochundersöka om slutsatserna blir annorlunda i denna skala. Skogliga analyser på beståndsnivåblir gärna endimensionella, då en funktion eller ett värde analyseras i taget (produktion,ekonomin, rekreation, biodiversitet etc). Tidsperspektivet blir ofta syntetiskt behandlat genomexempelvis val av diskonteringsfaktor i en nuvärdeskalkyl. Skogen som system tillhandahållersamtidigt en mängd varor, tjänster och andra värden. Då det är kombinationen av en mängdbestånd som utgör detta system krävs analyser på systemnivå för att skapa en helhetsbild.Vår förhoppning är att denna rapport leder till ökad kunskap och förståelse för de olikakomplexa samband och avvägningar som det svenska skogsbruket kommer att möta. Ett storttack riktas till forskningsprogrammen Mistra-SWECIA och Future Forests som har finansieratdetta projekt.
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| 4. |
- Lundmark, Tomas, et al.
(författare)
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Potential Roles of Swedish Forestry in the Context of Climate Change Mitigation
- 2014
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Ingår i: Forests. - Basel, Switzerland : MDPI AG. - 1999-4907. ; 5:4, s. 557-578
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Tidskriftsartikel (refereegranskat)abstract
- In Sweden, where forests cover more than 60% of the land area, silviculture and the use of forest products by industry and society play crucial roles in the national carbon balance. A scientific challenge is to understand how different forest management and wood use strategies can best contribute to climate change mitigation benefits. This study uses a set of models to analyze the effects of different forest management and wood use strategies in Sweden on carbon dioxide emissions and removals through 2105. If the present Swedish forest use strategy is continued, the long-term climate change mitigation benefit will correspond to more than 60 million tons of avoided or reduced emissions of carbon dioxide annually, compared to a scenario with similar consumption patterns in society but where non-renewable products are used instead of forest-based products. On average about 470 kg of carbon dioxide emissions are avoided for each cubic meter of biomass harvested, after accounting for carbon stock changes, substitution effects and all emissions related to forest management and industrial processes. Due to Sweden’s large export share of forest-based products, the climate change mitigation effect of Swedish forestry is larger abroad than within the country. The study also shows that silvicultural methods to increase forest biomass production can further reduce net carbon dioxide emissions by an additional 40 million tons of per year. Forestry’s contribution to climate change mitigation could be significantly increased if management of the boreal forest were oriented towards increased biomass production and if more wood were used to substitute fossil fuels and energy-intensive materials.
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| 5. |
- Nordström, Eva-Maria, et al.
(författare)
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Impacts of global climate change mitigation scenarios on forests and harvesting in Sweden
- 2016
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Ingår i: Canadian Journal of Forest Research. - : Canadian Science Publishing. - 0045-5067 .- 1208-6037. ; 46:12, s. 1427-1438
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Tidskriftsartikel (refereegranskat)abstract
- Under climate change, the importance of biomass resources is likely to increase and new approaches are needed to analyze future material and energy use of biomass globally and locally. Using Sweden as an example, we present an approach that combines global and national land-use and forest models to analyze impacts of climate change mitigation ambitions on forest management and harvesting in a specific country. National forest impact analyses in Sweden have traditionally focused on supply potential with little reference to international market developments. In this study, we use the global greenhouse gas concentration scenarios from the Intergovernmental Panel for Climate Change to estimate global biomass demand and assess potential implications on harvesting and biodiversity in Sweden. The results show that the short-term demand for wood is close to the full harvesting potential in Sweden in all scenarios. Under high bioenergy demand, harvest levels are projected to stay high over a longer time and particularly impact the harvest levels of pulpwood. The area of old forest in the managed landscape may decrease. This study highlights the importance of global scenarios when discussing national-level analysis and pinpoints trade-offs that policy making in Sweden may need to tackle in the near future.
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| 6. |
- Poudel, Bishnu Chandra, et al.
(författare)
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Effects of climate change on biomass production and substitution in north-central Sweden
- 2011
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Ingår i: Biomass and Bioenergy. - : Elsevier. - 0961-9534 .- 1873-2909. ; 35:10, s. 4340-4355
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Tidskriftsartikel (refereegranskat)abstract
- In this study we estimate the effects of climate change on forest production in north-central Sweden, as well as the potential climate changemitigation feedback effects of the resulting increased carbon stock and forest product use. Our results show that an average regional temperature rise of 4 °C over the next 100 years may increase annual forest production by 33% and potential annual harvest by 32%, compared to a reference case without climate change. This increased biomass production, if used to substitute fossil fuels and energy-intensive materials, can result in a significant net carbon emission reduction. We find that carbon stock in forest biomass, forest soils, and wood products also increase, but this effect is less significant than biomass substitution. A total net reduction in carbon emissions of up to 104 Tg of carbon can occur over 100 years, depending on harvest level and reference fossil fuel. © 2011 Elsevier Ltd.
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| 7. |
- Poudel, Bishnu Chandra, et al.
(författare)
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Potential effects of intensive forestry on biomass production and total carbon balance in north-central Sweden
- 2012
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Ingår i: Environmental Science and Policy. - : Elsevier BV. - 1462-9011 .- 1873-6416. ; 15:1, s. 106-124
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Tidskriftsartikel (refereegranskat)abstract
- We quantify the potential effects of intensive forest management activities on forest production in north-central Sweden over the next 100 years, and calculate the potential climate change mitigation feedback effect due to the resulting increased carbon stock and increased use of forest products. We analyze and compare four different forest management scenarios (Reference, Environment, Production, and Maximum), all of which include the expected effects of climate change based on SRES B2 scenario. Forest management practices are intensified in Production scenario, and further intensified in Maximum scenario. Four different models, BIOMASS, HUGIN, Q-model, and Substitution model, were used to quantify net primary production, forest production and harvest potential, soil carbon, and biomass substitution of fossil fuels and non-wood materials, respectively. After integrating the models, our results show that intensive forestry may increase forest production by up to 26% and annual harvest by up to 19%, compared to the Reference scenario. The greatest single effect on the carbon balance is from using increased biomass production to substitute for fossil fuels and energy intensive materials. Carbon stocks in living tree biomass, forest soil and wood products also increase. In total, a net carbon emission reduction of up to 132 Tg (for Maximum scenario) is possible during the next 100 years due to intensive forest management in two Swedish counties, Jämtland and Västernorrland.
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| 8. |
- Roberge, Jean-Michel, et al.
(författare)
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Socio-ecological implications of modifying rotation lengths in forestry
- 2016
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Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 45, s. 109-123
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Tidskriftsartikel (refereegranskat)abstract
- The rotation length is a key component of even-aged forest management systems. Using Fennoscandian forestry as a case, we review the socioecological implications of modifying rotation lengths relative to current practice by evaluating effects on a range of ecosystem services and on biodiversity conservation. The effects of shortening rotations on provisioning services are expected to be mostly negative to neutral (e.g. production of wood, bilberries, reindeer forage), while those of extending rotations would be more varied. Shortening rotations may help limit damage by some of today's major damaging agents (e.g. root rot, cambium-feeding insects), but may also increase other damage types (e.g. regeneration pests) and impede climate mitigation. Supporting (water, soil nutrients) and cultural (aesthetics, cultural heritage) ecosystem services would generally be affected negatively by shortened rotations and positively by extended rotations, as would most biodiversity indicators. Several effect modifiers, such as changes to thinning regimes, could alter these patterns.
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