SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Berglund Göran) "

Sökning: WFRF:(Berglund Göran)

  • Resultat 1-10 av 376
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
2.
  • Agudo, Antonio, et al. (författare)
  • Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition.
  • 2006
  • Ingår i: Cancer Epidemiology Biomarkers & Prevention. - 1055-9965. ; 15:12, s. 2427-34
  • Tidskriftsartikel (refereegranskat)abstract
    • Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C > A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus -3859G > A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis.
3.
  •  
4.
  • Baskaran, Preetisri, et al. (författare)
  • Modelling the influence of ectomycorrhizal decomposition on plant nutrition and soil carbon sequestration in boreal forest ecosystems
  • 2016
  • Ingår i: NEW PHYTOLOGIST. - 1469-8137. ; 213:3, s. 1452-1465
  • Tidskriftsartikel (refereegranskat)abstract
    • Tree growth in boreal forests is limited by nitrogen (N) availability. Most boreal forest trees form symbiotic associations with ectomycorrhizal (ECM) fungi, which improve the uptake of inorganic N and also have the capacity to decompose soil organic matter (SOM) and to mobilize organic N (&lsquo;ECM decomposition').<br />To study the effects of &lsquo;ECM decomposition' on ecosystem carbon (C) and N balances, we performed a sensitivity analysis on a model of C and N flows between plants, SOM, saprotrophs, ECM fungi, and inorganic N stores.<br />The analysis indicates that C and N balances were sensitive to model parameters regulating ECM biomass and decomposition. Under low N availability, the optimal C allocation to ECM fungi, above which the symbiosis switches from mutualism to parasitism, increases with increasing relative involvement of ECM fungi in SOM decomposition. Under low N conditions, increased ECM organic N mining promotes tree growth but decreases soil C storage, leading to a negative correlation between C stores above- and below-ground.<br />The interplay between plant production and soil C storage is sensitive to the partitioning of decomposition between ECM fungi and saprotrophs. Better understanding of interactions between functional guilds of soil fungi may significantly improve predictions of ecosystem responses to environmental change.
  •  
5.
  • Berglund, Jonas, et al. (författare)
  • Novel origins of copy number variation in the dog genome
  • 2012
  • Ingår i: Genome Biology. - 1465-6906 .- 1474-760X. ; 13:8, s. R73
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Copy number variants (CNVs) account for substantial variation between genomes and are a major source of normal and pathogenic phenotypic differences. The dog is an ideal model to investigate mutational mechanisms that generate CNVs as its genome lacks a functional ortholog of the PRDM9 gene implicated in recombination and CNV formation in humans. Here we comprehensively assay CNVs using high-density array comparative genomic hybridization in 50 dogs from 17 dog breeds and 3 gray wolves. RESULTS: We use a stringent new method to identify a total of 430 high-confidence CNV loci, which range in size from 9 kb to 1.6 Mb and span 26.4 Mb, or 1.08%, of the assayed dog genome, overlapping 413 annotated genes. Of CNVs observed in each breed, 98% are also observed in multiple breeds. CNVs predicted to disrupt gene function are significantly less common than expected by chance. We identify a significant overrepresentation of peaks of GC content, previously shown to be enriched in dog recombination hotspots, in the vicinity of CNV breakpoints. CONCLUSIONS: A number of the CNVs identified by this study are candidates for generating breed-specific phenotypes. Purifying selection seems to be a major factor shaping structural variation in the dog genome, suggesting that many CNVs are deleterious. Localized peaks of GC content appear to be novel sites of CNV formation in the dog genome by non-allelic homologous recombination, potentially activated by the loss of PRDM9. These sequence features may have driven genome instability and chromosomal rearrangements throughout canid evolution.
6.
  • Bingham, Sheila A, et al. (författare)
  • Is the association with fiber from foods in colorectal cancer confounded by folate intake?
  • 2005
  • Ingår i: Cancer Epidemiology Biomarkers & Prevention. - 1055-9965. ; 14:6, s. 1552-6
  • Tidskriftsartikel (refereegranskat)abstract
    • The effect of multivariate adjustment including folate on the strong protective effect of fiber in foods on colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition was investigated in 1,721 cases identified in the latest follow-up. The inclusion of an additional 656 cases confirmed our previously published results, with a strong and significant reduction in colorectal cancer risk of similar to 9% for each uncalibrated quintile increase in fiber (P-linear trend < 0.001) compared with an 8% reduction in our previous report, which had not been adjusted for folate. Inclusion of the other covariates (physical activity, alcohol, smoking, and red and processed meat) confirmed this significant inverse association for colon cancer and strengthened the association with left-sided colon cancer (P < 0.001). After maximum adjustment, the association between fiber and rectal cancer was not significant, as in our previous analysis. The association with fiber from different food sources was analyzed, but again, there were no significance trends after maximum adjustment.
7.
  • Borgquist, Signe, et al. (författare)
  • Diet and body constitution in relation to sub-groups of breast cancer defined by tumour grade, proliferation and key cell cycle regulators.
  • 2007
  • Ingår i: Breast Cancer Research. - BioMed Central. - 1465-5411. ; 9:1, s. 11-11
  • Tidskriftsartikel (refereegranskat)abstract
    • Background The general lack of clear associations between diet and breast cancer in epidemiological studies may partly be explained by the fact that breast cancer is a heterogeneous disease that may have disparate genetic associations and different aetiological bases. Method A total of 346 incident breast cancers in a prospective cohort of 17,035 women enrolled in the Malmo Diet and Cancer study ( Sweden) were subcategorized according to conventional pathology parameters, proliferation and expression of key cell cycle regulators. Subcategories were compared with prediagnostic diet and body measurements using analysis of variance. Results A large hip circumference and high body mass index were associated with high grade tumours ( P = 0.03 and 0.009, respectively), whereas low energy and unadjusted fat intakes were associated with high proliferation ( P = 0.03 and 0.004, respectively). Low intakes of saturated, monounsaturated and polyunsaturated fatty acids were also associated with high proliferation ( P = 0.02, 0.004 and 0.003, respectively). Low energy and unadjusted fat intakes were associated with cyclin D-1 overexpression ( P = 0.02 and 0.007, respectively), whereas cyclin E overexpression was positively correlated with fat intake. Oestrogen receptor status and expression of the tumour suppressor gene p27 were not associated with either diet or body constitution. Conclusion Low energy and low total fat ( polyunsaturated fatty acids in particular) intakes, and high body mass index were associated with relatively more malignant breast tumours. Dietary behaviours and body constitution may be associated with specific types of breast cancer defined by conventional pathology parameters and cyclin D1 and cyclin E expression. Further studies including healthy control individuals are needed to confirm our results.
8.
  • Britton, Julie A, et al. (författare)
  • Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
  • 2008
  • Ingår i: Haematologica. - 1592-8721. ; 93:11, s. 1666-1677
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. DESIGN AND METHODS: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. RESULTS: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50, 95% CI 1.14-1.98) for highest versus lowest quartile; p-trend &lt; 0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). CONCLUSIONS: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.
  •  
9.
  • Cust, Anne E, et al. (författare)
  • Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort
  • 2007
  • Ingår i: American Journal of Epidemiology. - Oxford University Press. - 0002-9262. ; 166:8, s. 912-923
  • Tidskriftsartikel (refereegranskat)abstract
    • The associations of dietary total carbohydrates, overall glycemic index, total dietary glycemic load, total sugars, total starch, and total fiber with endometrial cancer risk were analyzed among 288,428 women in the European Prospective Investigation into Cancer and Nutrition cohort (1992-2004), including 710 incident cases diagnosed during a mean 6.4 years of follow-up. Cox proportional hazards models were used to estimate relative risks and 95% confidence intervals. There were no statistically significant associations with endometrial cancer risk for increasing quartile intakes of any of the exposure variables. However, in continuous models calibrated by using 24-hour recall values, the multivariable relative risks were 1.61 (95% confidence interval: 1.06, 2.45) per 100 g/day of total carbohydrates, 1.40 (95% confidence interval: 0.99, 1.99) per 50 units/day of total dietary glycemic load, and 1.36 (95% confidence interval: 1.05, 1.76) per 50 g/day of total sugars. These associations were stronger among women who had never used postmenopausal hormone therapy compared with ever users (total carbohydrates P-heterogeneity = 0.04). Data suggest no association of overall glycemic index, total starch, and total fiber with risk, and a possible modest positive association of total carbohydrates, total dietary glycemic load, and total sugars with risk, particularly among never users of hormone replacement therapy.
10.
  • Danesh, John, et al. (författare)
  • EPIC-Heart: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries
  • 2007
  • Ingår i: European Journal of Epidemiology. - Springer. - 1573-7284. ; 22:2, s. 129-141
  • Tidskriftsartikel (refereegranskat)abstract
    • EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition ( EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle ( especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants ( 366,521 women and 153,457 men, mostly aged 35 - 70 years) in 23 centres in 10 European countries commenced follow-up for causespecific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 376
Åtkomst
fritt online (109)
Typ av publikation
tidskriftsartikel (326)
konferensbidrag (26)
rapport (9)
samlingsverk (redaktörskap) (4)
annan publikation (3)
bokkapitel (3)
visa fler...
bok (2)
forskningsöversikt (2)
licentiatavhandling (1)
visa färre...
Typ av innehåll
refereegranskat (340)
övrigt vetenskapligt (33)
populärvet., debatt m.m. (3)
Författare/redaktör
Berglund, Göran, (258)
Hedblad, Bo, (79)
Riboli, Elio (63)
Overvad, Kim (60)
Boeing, Heiner (58)
Tumino, Rosario (55)
visa fler...
Bueno-de-Mesquita, H ... (52)
Janzon, Lars, (52)
Linseisen, Jakob (51)
Trichopoulou, Antoni ... (51)
Bingham, Sheila (49)
Palli, Domenico, (47)
Hallmans, Göran, (47)
Lund, Eiliv (44)
Clavel-Chapelon, Fra ... (44)
Kaaks, Rudolf (44)
Panico, Salvatore, (44)
Tjonneland, Anne (42)
Vineis, Paolo (42)
Peeters, Petra H M (42)
Engström, Gunnar, (41)
Manjer, Jonas (40)
Khaw, Kay-Tee (39)
Slimani, Nadia (36)
Olsen, Anja (35)
Boutron-Ruault, Mari ... (34)
Wirfält, Elisabet (34)
Trichopoulos, Dimitr ... (34)
Melander, Olle, (33)
Ferrari, Pietro (33)
Tjønneland, Anne (29)
Norat, Teresa (28)
Nilsson, Peter, (28)
Allen, Naomi (28)
González, Carlos A (26)
Ardanaz, Eva, (26)
Martínez, Carmen (26)
Gullberg, Bo, (26)
Jenab, Mazda (25)
Tjonneland, A (24)
Nilsson, Jan-Åke, (24)
Navarro, Carmen (24)
Barricarte, Aurelio (23)
Larrañaga, Nerea (20)
Berrino, Franco (20)
Quiros, Josè R (20)
Key, Timothy J (19)
Sacerdote, Carlotta (17)
Riboli, E (17)
Dorronsoro, Miren (17)
visa färre...
Lärosäte
Lunds universitet (269)
Umeå universitet (72)
Uppsala universitet (29)
Göteborgs universitet (19)
Sveriges Lantbruksuniversitet (16)
Chalmers tekniska högskola (16)
visa fler...
Karolinska Institutet (15)
Högskolan i Halmstad (13)
Linköpings universitet (8)
Malmö universitet (7)
Stockholms universitet (4)
Högskolan Kristianstad (3)
Södertörns högskola (2)
Linnéuniversitetet (2)
Blekinge Tekniska Högskola (2)
Karlstads universitet (2)
Kungliga Tekniska Högskolan (1)
Luleå tekniska universitet (1)
RISE (1)
Örebro universitet (1)
Högskolan i Borås (1)
VTI - Statens väg- och transportforskningsinstitut (1)
visa färre...
Språk
Engelska (347)
Svenska (26)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (290)
Naturvetenskap (26)
Teknik (23)
Lantbruksvetenskap (13)
Samhällsvetenskap (9)
Humaniora (6)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy