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1.
  • Fuchs, A., et al. (författare)
  • Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization
  • 2018
  • Ingår i: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.
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3.
  • Mastantuoni, Gabriella G., et al. (författare)
  • Rationally designed conductive wood with mechanoresponsive electrical resistance
  • 2024
  • Ingår i: Composites. Part A, Applied science and manufacturing. - : Elsevier BV. - 1359-835X .- 1878-5840. ; 178
  • Tidskriftsartikel (refereegranskat)abstract
    • Porous cellular foams, combining lightweight, high strength, and compressibility, hold great promise in a wide range of advanced applications. Here, the native structure of pine wood was modified by in-situ lignin sulfonation and unidirectional freezing, resulting in an alveolate structure inside the wood cell wall with arrays of sub-100 nm channels. The obtained wood foam exhibited highly enhanced permeability while retaining the native cellular arrangement and high lignin and hemicellulose content. Such engineered cellular foam contributed to superior mechanical performance with compressive strength of 9 MPa and Young's modulus of 344 MPa in the longitudinal direction. The high porosity allowed homogeneous infiltration of conductive polymer PEDOT:PSS inside the wood cell wall. The resulting composite exhibited high conductivity, sponge-like compressibility and the ability to modulate electrical resistance in a reversible manner in the radial direction. This rationally designed conductive wood demonstrated potential in durable and ultrasensitive pressure-responsive devices and strain sensors.
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