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- Berglund, Per, et al.
(författare)
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Linking Education and Research : A Roadmap for Higher Education Institutions at the Dawn of the Knowledge Society
- 2019
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Ingår i: Linking education and research. - Basel, Switzerland : MDPI. ; , s. 11-33
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In an era characterized by a move towards a “knowledge society”, universities are central in fostering “knowledgeability”, that is the reflexive understanding of knowledge in knowledge societies. The objective of “knowledgeability” can be met through creating a stronger link between education and research. Furthermore, overall student performance, for example in critical thinking and problem solving, can be improved if research-related activities are incorporated into the curriculum.The aim of this paper is to use international examples to discuss the research- education nexus from four different perspectives, namely context, policy, implementation and quality, with case studies from higher education institutions in Singapore and Sweden.We suggest that different integrative technologies can be used to enhance the links, but it will be essential to consider the inputs of training, service and support in using new technology. Interestingly, the act of evaluating the link between education and research will increase awareness of this linkage by stakeholders involved in both education and research. In turn the link can be strengthened, contributing to increased quality in both education and research.
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| 2. |
- Engelmark Cassimjee, Karim
(författare)
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Tools in biocatalysis : enzyme immobilisation on silica and synthesis of enantiopure amines
- 2010
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis presents two techniques in the field of biocatalysis: An enzyme immobilisation method based on the His6-tag for attachment on modified silica oxide beads, and it’s employment in aqueous and organic medium for synthesis applications. The method functions as a one step extraction and immobilisation protocol. An equilibrium displacement system which enables complete conversion in reactions with ω-transaminases where isopropylamine is the donor, a route for synthesis of pharmaceutically interesting enantiopure amines. Biocatalysis is predicted to be a paramount technology for an environmentally sustainable chemical industry, to which every newly developed method represents a small but important step. The work done here is aimed to be a part of this development.
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| 3. |
- Anderson, Mattias
(författare)
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Amine Transaminases in Multi-Step One-Pot Reactions
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products. In order to make the production of these kinds of compounds more efficient from both a practical and an environmental point of view, amine transaminases were incorporated into multi-step one-pot reactions. With this kind of methodology there is no need for isolation of intermediates, and thus unnecessary work-up steps can be omitted and formation of waste is prevented. Amine transaminases were successfully combined with other enzymes for multi-step synthesis of valuable products: With ketoreductases all four diastereomers of a 1,3-amino alcohol could be obtained, and the use of a lipase allowed for the synthesis of natural products in the form of capsaicinoids. Amine transaminases were also successfully combined with metal catalysts based on palladium or copper. This methodology allowed for the amination of alcohols and the synthesis of chiral amines such as the pharmaceutical compound Rivastigmine. These examples show that the use of amine transaminases in multi-step one-pot reactions is possible, and hopefully this concept can be further developed and applied to make industrial processes more sustainable and efficient in the future.
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| 4. |
- Anderson, Mattias, et al.
(författare)
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Chemoenzymatic amination of alcohols by combining oxidation catalysts with transaminases in one pot
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Chemoenzymatic methods for the amination of alcohols have been developed. The reactions were performed in a one-pot two-step fashion, where the alcohol starting material was first oxidized to the corresponding carbonyl compound and then subsequently converted to the amine product with an enzymatic system based on an amine transaminase. The enzyme system was able to operate in a water/organic solvent two-phase system in the presence of either a heterogeneous palladium(0) catalyst or a homogeneous copper(I) catalyst. High conversions to the product amines were achieved for a range of substituted benzyl alcohols and similar compounds, but unfortunately the use of aliphatic alcohols resulted in lower conversions and secondary alcohols could not be converted to the corresponding amines with this methodology.
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| 9. |
- Berglund, Per-Olof
(författare)
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Investigation of acoustic source characterisation and installation effects for small axial fans
- 2003
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Fans are often used in equipment such as home appliances andelectronic equipment where the margin of profit is small butcustomers demands on a low noise level are high. Therefore,methods for predicting the noise emitted by an applicationincluding one or several fans are desirable in order toimprove, accelerate and reduce the cost of low-noise design.The Noise Shaping Technology (NST) has been developed withinthe EC-project NABUCCO in order to fulfil the aboverequirements on a prediction method. According to NST, thenoise source (not necessary a fan) is described by one orseveral noise descriptors, CSSs, and the correspondingtransmission paths through the structure described by one orseveral transfer functions, ACFs. In this thesis, theapplicability of NST is evaluated on a cabinet for electronicequipment where small axial cooling fans constitute the primarysources of the airborne sound.As an axial fan is a complex source of sound,simplifications are necessary when modelling its acousticproperties. Therefore, the sound radiation of an axial fan infree space was examined by expanding the generated soundpressure field into spherical harmonics. The conclusion on asource model for the cabinet example, where the fans are moreor less In-duct mounted, is a modified single axial dipole. Themodel is expected to be valid in the entire frequency range ofinterest except in the mid-frequency range where the modaldensity is low. In order to improve the source model in thisfrequency range, a future model based on a rotating dipole isproposed.The sound power of a small axial fan is measured in an ISO10302 test-rig. In order to take account of flow conditions,acoustically transparent ducts have been developed. These shallbe attached to the test-rig when measuring the sound power ofthe fan. A simple but practical method of how to correct thesound power for the baffling effect of the test-rig has alsobeen developed. Finally, the sound power can be converted intodipole force, which is the airborne CSS corresponding to thesingle axial dipole model.The corresponding airborne transfer function (ACF), i.e.,from dipole force at the source point to sound pressure at thereceiver point, is measured reciprocally by taking use ofLyamshevs reciprocity relation.From multiplication of the CSS and the ACF, the soundpressure can be predicted. The prediction shows quite goodagreement with the measured values.Keywords:axial fan, airborne sound, sourcecharacterisation, transmission path analysis, In-duct,spherical harmonics, rotating dipole, installation effects, ISO10302, flow conditions, baffling effect, acousticallytransparent ducts, Lyamshevs reciprocity relation, reciprocity,CSS, ACF, GSM, NST.
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