| 1. |
- Bergman, Åke, et al.
(författare)
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Science and policy on endocrine disrupters must not be mixed : a reply to a "common sense" intervention by toxicology journal editors
- 2013
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Ingår i: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.
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| 2. |
- Johannesson, Pär, 1969, et al.
(författare)
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A Robustness Approach to Reliability
- 2013
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Ingår i: Quality and Reliability Engineering International. - : Wiley. - 1099-1638 .- 0748-8017. ; 29:1, s. 17-32
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Forskningsöversikt (refereegranskat)abstract
- Reliability of products is here regarded with respect to failure avoidance rather than probability of failure. To avoid failures,we emphasize variation and suggest some powerful tools for handling failures due to variation. Thus, instead of technicalcalculation of probabilities from data that usually are too weak for correct results, we emphasize the statistical thinking thatputs the designers focus on the critical product functions.Making the design insensitive to unavoidable variation is called robust design and is handled by (i) identification andclassification of variation, (ii) design of experiments to find robust solutions, and (iii) statistically based estimations of propersafety margins.Extensions of the classical failure mode and effect analysis (FMEA) are presented. The first extension consists of identifyingfailure modes caused by variation in the traditional bottom–up FMEA analysis. The second variation mode and effect analysis(VMEA) is a top–down analysis, taking the product characteristics as a starting point and analyzing how sensitive thesecharacteristics are to variation.In cases when there is sufficient detailed information of potential failure causes, the VMEA can be applied in its mostadvanced mode, the probabilistic VMEA. Variation is then measured as statistical standard deviations, and sensitivities aremeasured as partial derivatives. This method gives the opportunity to dimension tolerances and safety margins to avoidfailures caused by both unavoidable variation and lack of knowledge regarding failure processes.
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| 3. |
- Kortenkamp, Andreas, et al.
(författare)
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Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project
- 2020
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 21:9
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Tidskriftsartikel (refereegranskat)abstract
- The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood-brain and blood-placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation.
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