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| 2. |
- Bergström, Gunnar, et al.
(författare)
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A comprehensive workplace intervention and its outcome with regard to lifestyle, health and sick leave : the AHA study
- 2008
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Ingår i: Work. - 1051-9815 .- 1875-9270. ; 31:2, s. 167-180
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Tidskriftsartikel (refereegranskat)abstract
- This study is a prospective multicentre cohort study entitled Work and Health in the Processing and Engineering Industries, the AHA Study (AHA is the Swedish abbreviation for the study). Four large workplaces in Sweden participated during the years from 2000 to 2003. The present report has two objectives: (1) to present a comprehensive occupational health intervention programme and (2) to evaluate this programme with a focus on lifestyle (smoking and exercise), health related quality of life (HRQoL) and sick leave. Interventions were provided on an individual and group level, including evidence-based methods for four health/focus areas (individual level) and a group intervention based on a survey-feedback methodology. The analyses in this report were exclusively employed at an organizational level. The proportion of smokers decreased at three companies and the course of the HRQoL was advantageous at two of the companies as compared to a gainfully employed reference group. A significant decrease in sick leave was revealed at one company, whereas a break in an ascending sick-leave trend appeared at a second company as compared to their respective corporate groups. This comprehensive workplace intervention programme appears to have had positive effects on smoking habits, HRQoL and sick leave.
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| 3. |
- Lindqvist, Markus, et al.
(författare)
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Plasma glycosylphosphatidylinositol phospholipase D (GPI-PLD) and abdominal aortic aneurysm.
- 2012
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Ingår i: International Journal of Clinical and Experimental Medicine. - 1940-5901. ; 5:4, s. 306-9
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Tidskriftsartikel (refereegranskat)abstract
- Recent reviews state that a circulating biomarker predicting aortic rupture risk would be a powerful tool to stratify patients with small screen-detected abdominal aortic aneurysm (AAA). In a current proteomic pilot-study elevated levels of the enzyme Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) was shown in patients with small AAA compared with controls without aneurysm. In the present study we investigated the impact of plasma GPI-PLD as a biomarker in patients with AAA in relation to aneurysm size, and rupture. Plasma GPI-PLD was measured in patients with AAA (nonruptured, n=78 and ruptured, n=55) and controls without aneurysm (n=41) matched by age, sex and smoking habit. The plasma GPI-PLD levels were significantly lower in patients with ruptured compared nonruptured AAA which we interpreted as a result of hemodilution due to hemorrhage in patients with ruptured AAA. The plasma GPI-PLD levels were similar in patients with nonruptured AAA compared to the controls without aneurysm. Furthermore, there was no correlation between plasma GPI-PLD and aneurysm size in the group of patients with nonruptured AAA. In conclusion, the present study fails to show a connection between GPI-PLD and AAA. However, the definite role of GPI-PLD as a predictive marker needs to be further clarified in a follow-up cohort study.
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| 4. |
- Pettersson, Gunilla, et al.
(författare)
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Strong and bulky paperboard sheets from surface modified CTMP, manufactured at low energy
- 2015
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Ingår i: Nordic Pulp & Paper Research Journal. - 0283-2631 .- 2000-0669. ; 30:2, s. 318-324
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Tidskriftsartikel (refereegranskat)abstract
- A description is given regarding methods used to manufacture strong and bulky sheets from furnishes based on a broad range of surface modified CTMP qualities. Starch and CMC are adsorbed on the fibre surfaces using a multilayer or a MIX concept. It is shown that both the in-plane and out-of-plane strength for the CTMP based sheets after such surface treatment can be more than doubled at a maintained density. This can be utilized to improve bending stiffness or to reduce the basis weight in multi-ply paperboards.
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| 6. |
- Spikol, Daniel, et al.
(författare)
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Bridging the Distance from Research to Practice : Designing for Technology Enhanced Learning
- 2012
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Ingår i: NGL 2012 Next Generation Learning Conference. - Falun : Dalarna University. - 9789185941476 ; , s. 1-9
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Konferensbidrag (refereegranskat)abstract
- A grand challenge for educational research is to remove its weak link to practice. One of the strategies to confront these challenges can be through the use of Design-Based Research (DBR). A DBR approach includes working iterations of design, implementation and evaluation in real world learning contexts, making it especially suitable for research in Technology Enhanced Learning (TEL). This paper describes and contextualizes a workshop that points out the need to examine different design approaches and digital technology tools to explore TEL in educational practices. Since the goal of the workshop is to use multidiscipline perspectives of education and didactics (ED), computer science (CS), interaction design (ID), to show the complexity for supporting next generation learning, these perspectives will in the paper be described and put in relation to each other. What research questions within and in between the three perspectives should be included in a DBRapproach in order to inform and facilitate TELpractices. In the end, of the paper a multidisciplinary DBR-approach allowing a more holistic understanding of educational practices usin g TEL will be argued for.
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| 7. |
- Wallinder, Jonas, et al.
(författare)
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Discovery of a novel circulating biomarker in patients with abdominal aortic aneurysm: a pilot study using a proteomic approach.
- 2012
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Ingår i: Clinical and translational science. - : Wiley. - 1752-8062 .- 1752-8054. ; 5:1, s. 56-9
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Tidskriftsartikel (refereegranskat)abstract
- Abdominal aortic aneurysm (AAA) is a common condition with high mortality when ruptured. Most clinicians agree that small AAAs are best managed by ultrasonographic surveillance. However, it has been stated in recent reviews that a serum/plasma biomarker that predicts AAA rupture risk would be a powerful tool in stratifying patients with small AAA. Identification of such circulating biomarkers has been to date unsuccessful. In this study, we used a proteomic approach to find new, potential plasma AAA biomarker candidates. Prefractionated plasma samples were analyzed by two-dimensional differential in-gel electrophoresis to identify differentially expressed proteins between four patients with small AAA and four controls without aneurysm. Protein spots that differed significantly between patients and controls were selected and identified by mass spectrometry. Three protein spots had significantly different expression between patients and controls. The most interesting finding was that patients with small AAA had increased levels of the enzyme glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) compared with the controls without aneurysm. In conclusion, by using a proteomic approach, this pilot-study provides evidence of GPI-PLD as a novel potential plasma biomarker for AAA.
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