| 1. |
- Björkvall, Anders, 1972-, et al.
(författare)
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Analyzing Text and Discourse in the Social Sciences
- 2024. - Second
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Ingår i: Analyzing Text and Discourse. - London : Sage Publications. - 9781529601954 - 9781529601961 - 9781529679595
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Bokkapitel (refereegranskat)
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| 2. |
- Bergström, Gunnar, et al.
(författare)
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A comprehensive workplace intervention and its outcome with regard to lifestyle, health and sick leave : the AHA study
- 2008
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Ingår i: Work. - 1051-9815 .- 1875-9270. ; 31:2, s. 167-180
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Tidskriftsartikel (refereegranskat)abstract
- This study is a prospective multicentre cohort study entitled Work and Health in the Processing and Engineering Industries, the AHA Study (AHA is the Swedish abbreviation for the study). Four large workplaces in Sweden participated during the years from 2000 to 2003. The present report has two objectives: (1) to present a comprehensive occupational health intervention programme and (2) to evaluate this programme with a focus on lifestyle (smoking and exercise), health related quality of life (HRQoL) and sick leave. Interventions were provided on an individual and group level, including evidence-based methods for four health/focus areas (individual level) and a group intervention based on a survey-feedback methodology. The analyses in this report were exclusively employed at an organizational level. The proportion of smokers decreased at three companies and the course of the HRQoL was advantageous at two of the companies as compared to a gainfully employed reference group. A significant decrease in sick leave was revealed at one company, whereas a break in an ascending sick-leave trend appeared at a second company as compared to their respective corporate groups. This comprehensive workplace intervention programme appears to have had positive effects on smoking habits, HRQoL and sick leave.
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| 3. |
- Bergström, Göran, et al.
(författare)
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Idé- och ideologianalys
- 2018. - 4
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Ingår i: Textens mening och makt. - Lund : Studentlitteratur AB. - 9789144117928 ; , s. 125-168
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Edlund, Charlotta, et al.
(författare)
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The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota : a randomised multicentre clinical trial in Sweden
- 2022
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Ingår i: The Lancet - Infectious diseases. - : Elsevier. - 1473-3099 .- 1474-4457. ; 22:3, s. 390-400
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Use of third-generation cephalosporins, such as cefotaxime, is associated with an increased risk of selection for antimicrobial resistance, so alternative antibiotics need to be considered. The aim of the present study was to evaluate intestinal colonisation with third-generation cephalosporin-resistant pathogens following use of temocillin-an alternative antibiotic to cefotaxime that is potentially less prone to disturbing the intestinal microbiota-in empirical treatment of febrile urinary tract infection (UTI).METHODS: We did a randomised, multicentre, superiority, open-label phase 4 trial in patients who had been admitted to inpatient care in 12 Swedish hospitals with suspected or diagnosed febrile UTI (complicated or uncomplicated). To meet inclusion criteria, a patient was required to have at least one sign or symptom of pyelonephritis (ie, flank pain; costovertebral angle tenderness; and changes to urinary frequency or urgency or dysuria), a fever of 38·0°C or higher, and a positive urine dipstick (for nitrites, white blood cells, or both). Participants were also required to have an indication for intravenous antibiotic treatment. Participants were randomly assigned (1:1) to receive either 2 g temocillin or 1-2 g cefotaxime, by local investigators opening consecutive sealed randomisation envelopes that were generated centrally in advance. Both drugs were administered intravenously every 8 h. The trial was open label for investigators and patients, but those doing the microbiological analyses were masked to the groups. Participants were treated with antibiotics for 7-10 days (or up to 14 days if they had bacteraemia), at least 3 days of which were on the study drug; at day 4 and later, participants who were showing improvement could be given an oral antibiotic (ciprofloxacin, ceftibuten, cefixime, or co-trimoxazole). Patients not showing improvement were regarded as having treatment failures. Rectal swabs were collected at three timepoints: at baseline (before the first dose), after the last dose of study drug, and 7-10 days after treatment stopped. The composite primary outcome was colonisation with Enterobacterales with reduced susceptibility to third-generation cephalosporins, or colonisation with toxin-producing Clostridioides difficile, or both, to evaluate disturbance of the intestinal microbiota. The study is registered in the EU Clinical Trials Register (EudraCT 2015-003898-15).FINDINGS: Between May 20, 2016, and July 31, 2019, 207 patients were screened for eligibility, of whom 55 patients were excluded. 152 participants were randomly assigned to groups: 77 (51%) patients received temocillin, 75 (49%) patients received cefotaxime. The composite primary endpoint was met by 18 (26%) of 68 participants receiving temocillin versus 30 (48%) of 62 patients receiving cefotaxime (risk difference -22% [95% CI -42% to -3%]), showing superiority of temocillin versus cefotaxime (ie, less disturbance of the intestinal microbiota). 43 adverse events were reported in 40 (52%) of 77 patients in the temocillin group, versus 46 adverse events in 34 (45%) of 75 patients in the cefotaxime group. Most events were of mild to moderate severity. 21 (27%) patients in the temocillin and 17 (23%) patients in the cefotaxime group had an adverse event that was considered to be associated with the study drug.INTERPRETATION: Temocillin was found to be less selective than cefotaxime of Enterobacterales with reduced susceptibility to third-generation cephalosporins, and it could therefore be a favourable alternative in the empirical treatment of febrile UTI. Use of this antibiotic could reduce hospital transmission and health-care-associated infections by these pathogens.
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| 5. |
- Engström, Joakim, et al.
(författare)
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Lung complications are common in intensive care treated patients with pelvis fractures : a retrospective cohort study
- 2016
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Ingår i: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. - : BioMed Central. - 1757-7241. ; 24
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Tidskriftsartikel (refereegranskat)abstract
- Background: The incidence of severe respiratory complications in patients with pelvis fractures needing intensive care have not previously been studied. Therefore, the aims of this registry study were to 1) determine the number of ICU patients with pelvis fractures who had severe respiratory complications 2) whether the surgical intervention in these patients is associated with the pulmonary condition and 3) whether there is an association between lung complications and mortality. We hypothesized that acute hypoxic failure (AHF) and acute respiratory distress syndrome (ARDS) 1) are common in ICU treated patients with pelvis fractures, 2) are not related to the reconstructive surgery, or to 3) to mortality.Methods: All patients in the database cohort (n = 112), scheduled for surgical stabilization of pelvis ring and/or acetabulum fractures, admitted to the general ICU at Uppsala University Hospital between 2007 and 2014 for intensive care were included.Results: The incidence of AHF/ARDS was 67 % (75/112 patients), i.e., the percentage of patients that at any period during the ICU stay fulfilled the AHF/ARDS criteria. The incidence of AHF was 44 % and incidence of ARDS was 23 %. The patients with AHF/ARDS had more lung contusions and pneumonia than the patients without AHF/ARDS. Overall, there were no significant changes in oxygenation variables associated with surgery. However, 23 patients with pre-operative normal lung status developed AHF/ARDS in relation to the surgical procedure, whereas 12 patients with AHF/ARDS normalized their lung condition. The patients who developed AHF/ARDS had a higher incidence of lung contusion (P = 0.04) and the surgical stabilization was performed earlier (5 versus 10 days) in these patients (P = 0.03).Conclusions: We found that the incidence of respiratory failure in ICU treated patients with pelvis fractures was high, that the procedure around surgical stabilization seems to be associated with a worsening in the respiratory function in patients with lung contusion, and that mortality was low and was probably not related to the respiratory condition.
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| 6. |
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| 7. |
- Karlsson, Patrik, 1973-, et al.
(författare)
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Galling resistance and wear mechanisms for cold-work tool steels in lubricated sliding against high strength stainless steel sheets
- 2012
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Ingår i: Wear. - Amsterdam : Elsevier. - 0043-1648 .- 1873-2577. ; 286-287, s. 92-97
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Tidskriftsartikel (refereegranskat)abstract
- Tool damage in sheet metal forming of stainless steel is of high concern for the forming industry. In the present work, ingot cast AISI D2 and advanced powder metallurgy tool steel (PM) cold-work tool steels were evaluated and ranked regarding wear mechanisms and galling resistance. Wear tests were performed using a slider-on-flat-surface (SOFS) tribometer in sliding against austenitic–ferritic (duplex) stainless steel sheets at different contact pressures in lubricated conditions. The best galling resistance was observed for the nitrogen alloyed PM tool steels. Abrasive scratching of the tool surfaces and transfer of sheet material due to adhesive wear were the main metal forming tool surface damage mechanisms. By increasing the hardness of one PM sheet metal forming tool grade, the galling resistance was enhanced.
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| 8. |
- Karlsson, Patrik, 1973-, et al.
(författare)
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Galling resistance evaluation of tool steels by two different laboratory test methods for sheet metal forming
- 2012
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Ingår i: Lubrication Science. - : John Wiley & Sons. - 0954-0075 .- 1557-6833. ; 24:6, s. 263-272
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Tidskriftsartikel (refereegranskat)abstract
- Adhesive accumulation of work material on the tool surface is today a major problem in many sheet metal-forming applications. Different laboratory test methods are used to investigate galling with respect to different tool materials, lubricants and process conditions. In the present study, the galling resistance of a modern nitrogen-alloyed powder metallurgy tool steel and an conventional ingot cast D2 type tool steel was evaluated under lubricated sliding against ferritic stainless steel sheets using a commercial pin-on-disc (POD) and an in-house made slider-on-flat-surface (SOFS) tribotester. The investigated tool steels ranked similarly in terms of galling resistanc in both test methods. However, sliding distances to galling were longer for the SOFS equipment due to continuous sliding on new lubricated sheet surface. Best performance was demonstrated by the powder metallurgy tool steel treated to 65 HRC. Differences in friction behaviour and galling initiation were analysed on the basis of the two different working conditions, i.e. open (SOFS) and closed (POD) tribosystems. Copyright © 2012 John Wiley & Sons, Ltd.
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| 9. |
- Karlsson, Patrik, 1973-, et al.
(författare)
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Influence of size and distribution of hard phases in tool steels on the early stage of galling
- 2012
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Ingår i: TOOL 2012. - Knittelfeld : Verlag "Gutenberghaus". - 9783901384523
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Konferensbidrag (refereegranskat)abstract
- In sheet metal forming processes, contact pressures are relatively high and total sliding distances are long, which demands tool steels to prevent tool damage and to resist galling. Galling is related to microscopic and macroscopic material transfer, but, the mechanisms of initiation are not thoroughly understood.To investigate galling initiation, lubricated sliding testing in the Slider-On-Flat-Surface (SOFS) tribometer was performed for ingot cast (IC) AISI D2 type and nitrogen alloyed powder metallurgy (PM) tool steel. The sheet grade was EN 1.4509 ferritic stainless steel. To reveal mechanisms in the early stages of galling initiation, transfer and accumulation of sheet material to the tool surfaces were characterized using AFM and SEM.It was found that already after a short sliding distance, transfer of sheet material occurred covering both the matrix and the hard phases. Macroscopic analysis of the contact area showed that initial material transfer and further lump growth occurred at positions corresponding to high plastic strains in the sheet material. Even though initial material transfer was observed for both tested tool steels, the sliding distance to the point where transfer and further lump formation occurred was longer for the PM tool steel. This was discussed in correlation to differences in size and distribution of the hard phases in the tool steels, which was confirmed by AFM and SEM.
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| 10. |
- Karlsson, Patrik, 1973-, et al.
(författare)
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Influence of work material proof stress and tool steel microstructure on galling initiation and critical contact pressure
- 2013
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Ingår i: Tribology International. - Amsterdam : Elsevier. - 0301-679X .- 1879-2464. ; 60, s. 104-110
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Tidskriftsartikel (refereegranskat)abstract
- EN 1.4301 (austenitic), EN 1.4509 (ferritic), EN 1.4162 (duplex) and EN 1.4310 C1000 (metastable austenitic) stainless steels were tested in lubricated sliding against an ingot cast EN X153WCrMoV12 and powder metallurgy nitrogen alloyed Uddeholm Vancron 40 tool steels to reveal critical to galling contact pressure, Pcr. The calculated Pcr were higher for steels with higher strength. At P>Pcr, due to plastic flow of sheet material, the tool is damaged substantially and wear-induced matrix damage causes rapid galling initiation. At P
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