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- Gustafsson, Åsa, et al.
(author)
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Mice with established airway inflammation exert differential cellular responses to inhaled hematite nanoparticles than healthy mice
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Other publication (other academic/artistic)abstract
- The aim of this study was to investigate the inflammatory and immunological responses in the airways and the lung-draining lymph nodes, following lung exposure to hematite nanoparticles (NPs). The responses to hematite NPs were evaluated in both non-sensitized healthy mice, and allergen-sensitized mice, in which the latter represent a group of sensitive individuals with allergic airway disease. This allergic airway disease was induced by sensitization and aerosol challenge to a respiratory allergen resulting in an established eosinophilic and lymphocytic airway inflammation at the time of NP exposure. The mice received either hematite NPs or vehicle (PBS) intratracheally and the cellular responses were evaluated on day 1, 2, and 7, following exposure.Intratracheal instillation of hematite NPs induced an increase of neutrophils, eosinophils, and lymphocytes in the airways of non-sensitized mice on day 1 and 2 following exposure. At these time-points the lymphocytes in the lymph nodes were also increased. In contrast, exposure to hematite NPs in sensitized mice induced a rapid and unspecific cellular reduction in the alveolar space on the first day after exposure. A similar decrease of lymphocytes was also observed in the mediastinal lymph nodes draining the airways. The study did not indicate a reduction of inflammatory cells in the lung tissue or a translocation of cells from alveolar space to lung tissue. Although, mucociliary cellular clearance could be a possible explanation, our finding of cellular decrease also in lung draining lymph nodes point at cell death as the most likely cause to this unspecific cellular reduction.The results indicate that cells in the airways and lymph nodes of individuals with established airway inflammation undergo cell death when exposed to iron oxide NPs. A possible reason to the toxic response is extensive generation of reactive oxygen species (ROS) in the pro-oxidative environment of inflamed airways, which is further catalyzed by Fe ions released by the hematite NPs, or by generation of ROS at the surface of the NPs. Such cell toxic response was not detected in healthy non-sensitized individuals. This study clearly demonstrates the different response of sensitized and non-sensitized mice, and highlights the importance of including individuals with respiratory disorders, such as allergic asthma, when evaluating health effects of inhaled nanomaterials.
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| 3. |
- Adamo, Hanibal, et al.
(author)
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Prostate cancer induces C/EBPβ expression in surrounding epithelial cells which relates to tumor aggressiveness and patient outcome
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Other publication (other academic/artistic)abstract
- Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non-malignant part of a tumor-bearing prostate lobe in rats was the transcription factor CCAAT/enhancer-binding protein-β (C/EBPβ). To explore this further, we examined C/EBPβ expression by quantitative RT-PCR, immunohistochemistry, and western blot in normal rat prostate tissue surrounding slow-growing non-metastatic Dunning G, rapidly growing poorly metastatic (AT-1), and rapidly growing highly metastatic (MatLyLu) rat prostate tumors―and also by immunohistochemistry in a tissue microarray (TMA) from prostate cancer patients managed by watchful waiting.In rats, C/EBPβ mRNA expression was upregulated in the surrounding tumor-bearing prostate lobe. In tumors and in the surrounding non-malignant prostate tissue, C/EBPβ was detected by immunohistochemistry in some epithelial cells and in infiltrating macrophages. The magnitude of glandular epithelial C/EBPβ expression in the tumor-bearing prostates was associated with tumor size, with distance to the tumor, and with tumor cell metastatic capacity.In prostate cancer patients, high expression of C/EBPβ in glandular epithelial cells in the surrounding tumor-bearing tissue was associated with accumulation of M1 macrophages (iNOS+) and a favorable outcome. High expression of C/EBPβ in tumor epithelial cells was associated with high Gleason score, high tumor cell proliferation, the presence of metastases at diagnosis, and poor outcome.
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| 5. |
- Bergström, Anders, 1965-
(author)
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Att bygga forskning
- 2010
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Other publication (film/video) (peer-reviewed)
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| 6. |
- Bergström, Anders, 1965-
(author)
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Om en odramatisk flytt
- 2015
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Other publication (film/video) (pop. science, debate, etc.)
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| 7. |
- Bergström, Anders, 1965-
(author)
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Restaureringshistorisk översikt (sammanfattning)
- 2009
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Other publication (pop. science, debate, etc.)abstract
- Stockholms slott ger i kraft av sin enhetliga yttre gestalt intryck av att ha tillkommit under en begränsad period. Men i själva verket är slottet resultatet av en lång byggnadsprocess. En översikt över de senaste trehundra årens försök att vidmakthålla fasaderna på Stockholms slott visar på motsvarande sätt att såväl skador som underhållsinsatser har varit ständigt återkommande.Ur kulturhistorisk synvinkel är slottets fasader alltså resultatet av många olika insatser från olika perioder. De numera frilagda stenarbetena är inte bara ett vittnesbörd om det förra sekelskiftets restaureringsideologi, de förstärker också bilden av slottet som hantverksprodukt. Den genomfärgade putsen är i sin tur anpassad till den anslutande stenen, med avsikt att ge ett enhetligt intryck även i tider av bristande underhåll. Fasaderna kan med andra ord betraktas som en konstnärlig helhetslösning, där estetiska och kulturhistoriska faktorer balanseras av faktorer som rör underhåll, material och teknik.Del av "FÖRSTUDIE: Stockholms slotts fasader - Långsiktigt underhåll av sten", s.7-9. Förstudien ingår i "Kulturfastighetsutredningen - Bilagor".
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| 9. |
- Bergström, Anders, 1965-
(author)
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The Importance of Colour
- 2023
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Other publication (film/video) (other academic/artistic)
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