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Sökning: WFRF:(Bergström Annika 1964 ) > Naturvetenskap

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1.
  • Wahlström, Annika, 1975, et al. (författare)
  • Production of deoxycholic acid by low-abundant microbial species is associated with impaired glucose metabolism
  • 2024
  • Ingår i: NATURE COMMUNICATIONS. - 2041-1723. ; 15:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Alterations in gut microbiota composition are suggested to contribute to cardiometabolic diseases, in part by producing bioactive molecules. Some of the metabolites are produced by very low abundant bacterial taxa, which largely have been neglected due to limits of detection. However, the concentration of microbially produced metabolites from these taxa can still reach high levels and have substantial impact on host physiology. To explore this concept, we focused on the generation of secondary bile acids by 7 alpha-dehydroxylating bacteria and demonstrated that addition of a very low abundant bacteria to a community can change the metabolic output dramatically. We show that Clostridium scindens converts cholic acid into the secondary bile acid deoxycholic acid (DCA) very efficiently even though the abundance of C. scindens is low, but still detectable by digital droplet PCR. We also show that colonization of germ-free female mice with a community containing C. scindens induces DCA production and affects host metabolism. Finally, we show that DCA correlates with impaired glucose metabolism and a worsened lipid profile in individuals with type 2 diabetes, which implies that this metabolic pathway may contribute to the development of cardiometabolic disease. Secondary bile acids are microbially produced metabolites linked to metabolic diseases. A challenge in microbiota research is to understand how bacteria collaborate to produce such bioactive molecules. Here, the authors show that adding a single low-abundance bacterial species to a community can significantly affect the metabolic output and host physiology.
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2.
  • Bergström, Annika, 1964, et al. (författare)
  • Hållbarhetens horisont
  • 2016
  • Ingår i: Bergström, A. & Harring, N. (red.). Hållbarhetens horisont. Samhälle, Opinion och Medier i Västsverige. - Göteborg : SOM-institutet. - 0284-4788. - 9789189673366 ; , s. 9-24
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