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Sökning: WFRF:(Bergström Reinhold)

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1.
  • Kvidal, P, et al. (författare)
  • Long-term follow-up of morbidity and mortality after aortic valve replacement with a mechanical valve prosthesis
  • Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X. ; 21, s. 1099-1111
  • Tidskriftsartikel (refereegranskat)abstract
    • AIMS: The aim of this study was to determine the incidence of valve-related complications in patients with a mechanical aortic valve prosthesis and to identify risk factors for an adverse outcome.METHODS AND RESULTS: In the 424 patients, event-free survival rates 5 and 10 years after aortic valve replacement were 62% and 37%, respectively. The linearized incidence of thromboembolic events was 4.4% per patient-year, and of anticoagulant-related haemorrhage 8.5% per patient-year. Advanced NYHA functional class, atrial fibrillation, pure aortic regurgitation and thromboembolism prior to surgery decreased event-free survival. A history of pre-operative thromboembolism increased the risk for a first embolic event after aortic valve replacement (relative hazard [RH] 3.2), but was even more strongly associated with the risk for repeated events (> or =2 events, RH 5.4). After each thromboembolic episode that occurred, the risk for a subsequent one was increased. The risk for at least one, and up to three or more haemorrhages was increased in patients with a pre-operative history of bleeding (RH 3.3-5.1) and of atrial fibrillation (RH 1.8-3.9). The risk for a subsequent event was increased by a history of repeated haemorrhages, a short interval since previous bleeding, and high age.CONCLUSIONS: There were few factors strongly related to valve related morbidity. However, previous bleedings and previous thromboembolism were powerful risk factors for repeated events.
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  • Adami, Johanna, et al. (författare)
  • Blood transfusion and non-Hodgkins lymphoma : Lack of association
  • 1997
  • Ingår i: Annals of Internal Medicine. - 0003-4819 .- 1539-3704. ; 127:5, s. 365-371
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Non-Hodgkin lymphoma is the seventh most commonly diagnosed malignant condition worldwide, and its incidence has increased markedly in recent decades. Blood transfusions have been implicated as a possible risk factor for non-Hodgkin lymphoma. OBJECTIVE: To determine whether blood transfusions are associated with an elevated risk for non-Hodgkin lymphoma. DESIGN: Population-based, nested case-control study. SETTING: Nationwide cohort in Sweden. PATIENTS: 361 patients with non-Hodgkin lymphoma and 705 matched controls, nested within a population-based cohort of 96795 patients at risk for blood transfusion between 1970 and 1983. Prospectively collected information on exposure was retrieved from computerized transfusion registries. MEASUREMENTS: Odds ratios obtained from conditional logistic regression models were used as measures of relative risks. RESULTS: No association was found between blood transfusions and the risk for non-Hodgkin lymphoma when patients who had received transfusions were compared with patients who had not received transfusions (odds ratio, 0.93 [95% CI, 0.71 to 1.23]). A reduction in risk was seen among persons who received transfusion of blood without leukocyte depletion (odds ratio, 0.72 [CI, 0.53 to 0.97]). Risk was not related to number of transfusions, and no interaction was seen with latency after transfusion. CONCLUSION: The findings in this study do not support previous observations of an association between blood transfusions and the risk for non-Hodgkin lymphoma.
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  • Adami, Johanna, et al. (författare)
  • Smoking and the risk of leukemia, lymphoma, and multiple myeloma (Sweden)
  • 1998
  • Ingår i: Cancer Causes and Control. - 0957-5243 .- 1573-7225. ; 9:1, s. 49-56
  • Tidskriftsartikel (refereegranskat)abstract
    • While several epidemiologic studies have indicated a link between smoking and the risk of developing hematolymphoproliferative cancers (chiefly leukemias, lymphomas, and multiple myelomas), in particular myeloid leukemia, the role of tobacco in the etiology of these neoplasms remains unclear. To evaluate the potential impact of tobacco use on development of leukemia, lymphoma, and multiple myeloma, we conducted a cohort study of 334,957 Swedish construction workers using prospectively collected exposure-information with complete long-term follow-up. A total of 1,322 incident neoplasms occurred during the study period, 1971-91. We found no significant association between smoking status, number of cigarettes smoked, or duration of smoking and the risk of developing leukemias, lymphomas, or multiple myeloma. There was a suggestion of a positive association between smoking and the risk of developing Hodgkin's disease, although the rate ratios were not significantly elevated, except for young current smokers. No positive dose-risk trends emerged. Our study provides no evidence that smoking bears any major relationship to the occurrence of leukemias, non-Hodgkin's lymphomas, or multiple myeloma.
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  • Akre [Fall], Katja, 1971-, et al. (författare)
  • Risk for gastric cancer after antibiotic prophylaxis in patients undergoing hip replacement
  • 2000
  • Ingår i: Cancer Research. - Birmingham, USA : American Asoociation for Cancer Research. - 0008-5472 .- 1538-7445. ; 60:22, s. 6376-80
  • Tidskriftsartikel (refereegranskat)abstract
    • Despite strong evidence of an association between Helicobacter pylori and gastric cancer, the benefit of eradicating H. pylori infection is unknown. Our aim was to test the hypothesis that exposure to high doses of antibiotics reduces risk for gastric cancer via possible eradication of H. pylori We conducted a nationwide case-control study nested in a cohort of 39,154 patients who underwent hip replacement surgery between 1965 and 1983. Such patients frequently receive prophylactic antibiotic treatment. During follow-up through 1989, we identified 189 incident cases of gastric cancer. For each case, three controls were selected from the cohort. Exposure data were abstracted from hospital records. Blood samples from a separate cohort undergoing hip replacement surgery were analyzed for anti-H. pylori IgG before and after surgery. Both long-term antibiotic treatment before surgery [odds ratio (OR), 0.3; 95% confidence interval (CI), 0.1-0.7] and prophylactic antibiotic treatment (OR, 0.7; 95% CI, 0.5-1.1) conferred a reduction in gastric cancer risk. The reduction appeared stronger after 5 years (OR, 0.6; 95% CI, 0.3-1.2) than during shorter follow-up after hip replacement (OR, 0.8; 95% CI, 0.4-1.7). There was an apparent decrease in risk with increasing body weight-adjusted doses of antibiotics (P = 0.13). However, the rate of H. pylori antibody disappearance was not strikingly higher in the cohort of patients undergoing hip replacement than in a control cohort. Our findings provide indirect support for the hypothesis that treatment with antibiotics at a relatively advanced age reduces the risk of gastric cancer.
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  • Berg, Lennart, et al. (författare)
  • Consumer confidence and consumption in Sweden
  • 1996
  • Rapport (övrigt vetenskapligt)abstract
    • The role of confidence indices in explaining consumption growth in Sweden during the period 1975-94 is analysed in this paper. We first analysed which variables influence the levels of the confidence indices. Two important such factors are found to be changes in real interest rates and changes in the inflation rate. Of the two forward-looking indices considered, the one regarding the personal financial situation is found to be more closely related to changes in consumption than the index regarding the general economic situation. The latter has no additional information content in the presence of the former. In a crude analysis the personal financial situation index explains about 37 % of the variance in the growth rate of consumption. The index has an important significant effect even in the presence of other vari-ables in the two types of consumption models that are considered, an Euler equation and a solved-out consumption model. In the latter model, the confidence index increases the ex-plained part of the variance in consumption growth from about 0.69 to 0.76. The real after-tax interest rate and the change in the inflation rate are important determinants of consumption. Financial wealth is more important than housing wealth and changes in debt also influence consumption. The solved-out consumption model is able to reflect the Swedish boom-to-bust cycle in consumption remarkably well.
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10.
  • Berg, Lennart, et al. (författare)
  • Consumer confidence and consumption in Sweden
  • 1996
  • Rapport (övrigt vetenskapligt)abstract
    • The role of confidence indices in explaining consumption growth in Sweden during the period 1975-94 is analysed in this paper. We first analysed which variables influence the levels of the confidence indices. Two important such factors are found to be cha
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  • Resultat 1-10 av 48
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