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- Bauer, M., et al.
(författare)
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Solar insolation in springtime influences age of onset of bipolar I disorder
- 2017
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Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 136:6, s. 571-582
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Forskningsöversikt (refereegranskat)abstract
- Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.
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| 2. |
- Fasoli, A., et al.
(författare)
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Chapter 5 : Physics of energetic ions
- 2007
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 47:6, s. S264-S284
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Forskningsöversikt (refereegranskat)abstract
- This chapter reviews the progress accomplished since the redaction of the first ITER Physics Basis (1999 Nucl. Fusion 39 2137-664) in the field of energetic ion physics and its possible impact on burning plasma regimes. New schemes to create energetic ions simulating the fusion-produced alphas are introduced, accessing experimental conditions of direct relevance for burning plasmas, in terms of the Alfvenic Mach number and of the normalised pressure gradient of the energetic ions, though orbit characteristics and size cannot always match those of ITER. Based on the experimental and theoretical knowledge of the effects of the toroidal magnetic field ripple on direct fast ion losses, ferritic inserts in ITER are expected to provide a significant reduction of ripple alpha losses in reversed shear configurations. The nonlinear fast ion interaction with kink and tearing modes is qualitatively understood, but quantitative predictions are missing, particularly for the stabilisation of sawteeth by fast particles that can trigger neoclassical tearing modes. A large database on the linear stability properties of the modes interacting with energetic ions, such as the Alfven eigenmode has been constructed. Comparisons between theoretical predictions and experimental measurements of mode structures and drive/damping rates approach a satisfactory degree of consistency, though systematic measurements and theory comparisons of damping and drive of intermediate and high mode numbers, the most relevant for ITER, still need to be performed. The nonlinear behaviour of Alfven eigenmodes close to marginal stability is well characterized theoretically and experimentally, which gives the opportunity to extract some information on the particle phase space distribution from the measured instability spectral features. Much less data exists for strongly unstable scenarios, characterised by nonlinear dynamical processes leading to energetic ion redistribution and losses, and identified in nonlinear numerical simulations of Alfven eigenmodes and energetic particle modes. Comparisons with theoretical and numerical analyses are needed to assess the potential implications of these regimes on burning plasma scenarios, including in the presence of a large number of modes simultaneously driven unstable by the fast ions.
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