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Lack of association...
Lack of association between modifiable exposures and glioma risk : a Mendelian randomization analysis
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Saunders, Charlie N. (author)
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Cornish, Alex J. (author)
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Kinnersley, Ben (author)
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Law, Philip J. (author)
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Claus, Elizabeth B. (author)
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Il'yasova, Dora (author)
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Schildkraut, Joellen (author)
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Barnholtz-Sloan, Jill S. (author)
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Olson, Sara H. (author)
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Bernstein, Jonine L. (author)
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Lai, Rose K. (author)
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Chanock, Stephen (author)
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Rajaraman, Preetha (author)
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Johansen, Christoffer (author)
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Jenkins, Robert B. (author)
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- Melin, Beatrice S. (author)
- Umeå universitet,Onkologi
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Wrensch, Margaret R. (author)
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Sanson, Marc (author)
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Bondy, Melissa L. (author)
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Houlston, Richard S. (author)
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(creator_code:org_t)
- 2019-10-30
- 2020
- English.
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In: Neuro-Oncology. - : OXFORD UNIV PRESS INC. - 1522-8517 .- 1523-5866. ; 22:2, s. 207-215
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Background. The etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian randomization (MR) framework to examine if lifestyle, cardiometabolic, and inflammatory factors influence the risk of glioma. This methodology reduces bias from confounding and is not affected by reverse causation. Methods. We identified genetic instruments for 37 potentially modifiable risk factors and evaluated their association with glioma risk using data from a genome-wide association study of 12488 glioma patients and 18169 controls. We used the estimated odds ratio of glioma associated with each of the genetically defined traits to infer evidence for a causal relationship with the following exposures: Lifestyle and dietary factors-height, plasma insulin-like growth factor 1, blood carnitine, blood methionine, blood selenium, blood zinc, circulating adiponectin, circulating carotenoids, iron status, serum calcium, vitamins (A1, B12, B6, E, and 25-hydroxyvitamin D), fatty acid levels (monounsaturated, omega-3, and omega-6) and circulating fetuin-A; Cardiometabolic factors-birth weight, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, total triglycerides, basal metabolic rate, body fat percentage, body mass index, fasting glucose, fasting proinsulin, glycated hemoglobin levels, diastolic and systolic blood pressure, waist circumference, waist-to-hip ratio; and Inflammatory factors- C-reactive protein, plasma interleukin-6 receptor subunit alpha and serum immunoglobulin E. Results. After correction for the testing of multiple potential risk factors and excluding associations driven by one single nucleotide polymorphism, no significant association with glioma risk was observed (ie, P-Corrected > 0.05). Conclusions. This study did not provide evidence supporting any of the 37 factors examined as having a significant influence on glioma risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cancer
- glioma
- Mendelian randomization
- risk
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- By the author/editor
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Saunders, Charli ...
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Cornish, Alex J.
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Kinnersley, Ben
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Law, Philip J.
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Claus, Elizabeth ...
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Il'yasova, Dora
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show more...
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Schildkraut, Joe ...
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Barnholtz-Sloan, ...
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Olson, Sara H.
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Bernstein, Jonin ...
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Lai, Rose K.
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Chanock, Stephen
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Rajaraman, Preet ...
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Johansen, Christ ...
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Jenkins, Robert ...
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Melin, Beatrice ...
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Wrensch, Margare ...
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Sanson, Marc
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Bondy, Melissa L ...
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Houlston, Richar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Neuro-Oncology
- By the university
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Umeå University