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Genome-wide associa...
Genome-wide association study of INDELs identified four novel susceptibility loci associated with lung cancer risk
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- Dai, Juncheng (author)
- Nanjing Medical University
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- Huang, Mingtao (author)
- Nanjing Medical University
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- Amos, Christopher I. (author)
- Baylor College of Medicine
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- Hung, Rayjean J. (author)
- Sinai Health System
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- Tardon, Adonina (author)
- University of Oviedo
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- Andrew, Angeline (author)
- Dartmouth-Hitchcock Medical Center,Radboud University Medical Center
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- Chen, Chu (author)
- Fred Hutchinson Cancer Research Center,Harvard University,Vanderbilt University Medical Center
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Christiani, David C. (author)
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- Albanes, Demetrius (author)
- National Cancer Institute, NCI
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- Rennert, Gadi (author)
- Technion - Israel Institute of Technology
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- Fan, Jingyi (author)
- Nanjing Medical University
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- Goodman, Gary (author)
- Swedish Medical Center
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- Liu, Geoffrey (author)
- Princess Margaret Hospital University of Toronto
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- Field, John K. (author)
- University of Liverpool
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- Grankvist, Kjell (author)
- Umeå University,Umeå universitet,Klinisk kemi
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Kiemeney, Lambertus A. (author)
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- Le Marchand, Loic (author)
- University of Hawaii Cancer Center
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- Schabath, Matthew B. (author)
- H. Lee Moffitt Cancer Center & Research Institute
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization
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Aldrich, Melinda C. (author)
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- Johansson, Mikael (author)
- Umeå University,Umeå universitet,Onkologi
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- Caporaso, Neil (author)
- National Cancer Institute, NCI
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- Lazarus, Philip (author)
- Washington State University College of Pharmacy
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- Lam, Stephan (author)
- British Columbia Cancer Agency
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- Bojesen, Stig E. (author)
- University of Copenhagen,Copenhagen University Hospital
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- Arnold, Susanne (author)
- University of Kentucky
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- Landi, Maria Teresa (author)
- National Cancer Institute, NCI
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- Risch, Angela (author)
- University of Salzburg
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- Wichmann, H-Erich (author)
- Ludwig-Maximilian University of Munich
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- Bickeboller, Heike (author)
- University Medical Center Göttingen
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- Brennan, Paul (author)
- International Agency for Research on Cancer, World Health Organization
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- Shete, Sanjay (author)
- University of Texas
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Brunnstrom, Hans (author)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Zienolddiny, Shan (author)
- National Institute of Occupational Health, Norway
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- Woll, Penella (author)
- University of Sheffield
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- Stevens, Victoria (author)
- American Cancer Society
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- Hu, Zhibin (author)
- Nanjing Medical University
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- Shen, Hongbing (author)
- Nanjing Medical University
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(creator_code:org_t)
- John Wiley & Sons, 2020
- 2020
- English.
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In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 146:10, s. 2855-2864
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Genome-wide association studies (GWAS) have identified 45 susceptibility loci associated with lung ncer. Only less than SNPs, small insertions and deletions (INDELs) are the second most abundant netic polymorphisms in the human genome. INDELs are highly associated with multiple human seases, including lung cancer. However, limited studies with large-scale samples have been available to stematically evaluate the effects of INDELs on lung cancer risk. Here, we performed a large-scale meta- alysis to evaluate INDELs and their risk for lung cancer in 23,202 cases and 19,048 controls. Functional notations were performed to further explore the potential function of lung cancer risk INDELs. nditional analysis was used to clarify the relationship between INDELs and SNPs. Four new risk loci re identified in genome-wide INDEL analysis (1p13.2: rs5777156, Insertion, OR = 0.92, p = 9.10 x 10(- ; 4q28.2: rs58404727, Deletion, OR = 1.19, p = 5.25 x 10(-7); 12p13.31: rs71450133, Deletion, OR = 09, p = 8.83 x 10(-7); and 14q22.3: rs34057993, Deletion, OR = 0.90, p = 7.64 x 10(-8)). The eQTL alysis and functional annotation suggested that INDELs might affect lung cancer susceptibility by gulating the expression of target genes. After conducting conditional analysis on potential causal SNPs, e INDELs in the new loci were still nominally significant. Our findings indicate that INDELs could be tentially functional genetic variants for lung cancer risk. Further functional experiments are needed to tter understand INDEL mechanisms in carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- INDELs
- lung cancer
- genome-wide association studies
- genome-wide association studies
- INDELs
- lung cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Dai, Juncheng
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Huang, Mingtao
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Amos, Christophe ...
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Hung, Rayjean J.
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Tardon, Adonina
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Andrew, Angeline
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show more...
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Chen, Chu
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Christiani, Davi ...
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Albanes, Demetri ...
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Rennert, Gadi
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Fan, Jingyi
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Goodman, Gary
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Liu, Geoffrey
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Field, John K.
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Grankvist, Kjell
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Kiemeney, Lamber ...
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Le Marchand, Loi ...
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Schabath, Matthe ...
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Johansson, Matti ...
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Aldrich, Melinda ...
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Johansson, Mikae ...
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Caporaso, Neil
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Lazarus, Philip
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Lam, Stephan
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Bojesen, Stig E.
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Arnold, Susanne
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Landi, Maria Ter ...
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Risch, Angela
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Wichmann, H-Eric ...
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Bickeboller, Hei ...
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Brennan, Paul
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Shete, Sanjay
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Melander, Olle
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Brunnstrom, Hans
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Zienolddiny, Sha ...
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Woll, Penella
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Stevens, Victori ...
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Hu, Zhibin
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Shen, Hongbing
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Lund University