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Using genetics to t...
Using genetics to test the causal relationship of total adiposity and periodontitis : Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium
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- Shungin, Dmitry (author)
- Lund University,Lunds universitet,Umeå universitet,Institutionen för odontologi,Medicin,Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Cornelis, Marilyn C. (author)
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Divaris, Kimon (author)
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Holtfreter, Birte (author)
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Shaffer, John R. (author)
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Yu, Yau-Hua (author)
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Barros, Silvana P. (author)
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Beck, James D. (author)
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Biffar, Reiner (author)
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Boerwinkle, Eric A. (author)
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Crout, Richard J. (author)
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Ganna, Andrea (author)
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- Hallmans, Göran (author)
- Umeå universitet,Enheten för biobanksforskning,Näringsforskning
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- Hindy, George (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Hu, Frank B. (author)
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- Kraft, Peter (author)
- Karolinska Institutet
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McNeil, Daniel W. (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Moss, Kevin L. (author)
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North, Kari E. (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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Ridker, Paul M. (author)
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Rimm, Eric B. (author)
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Rose, Lynda M. (author)
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- Rukh, Gull (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Teumer, Alexander (author)
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Weyant, Robert J. (author)
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Chasman, Daniel I. (author)
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Joshipura, Kaumudi (author)
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Kocher, Thomas (author)
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Magnusson, Patrik K. E. (author)
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Marazita, Mary L. (author)
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Offenbacher, Steve (author)
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Smith, George Davey (author)
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- Lundberg, Pernilla (author)
- Umeå universitet,Institutionen för odontologi
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Palmer, Tom M. (author)
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Timpson, Nicholas J. (author)
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi,Enheten för biobanksforskning
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Skåne University Hospital, Lund University; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- 2015-06-06
- 2015
- English.
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In: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 44:2, s. 638-650
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background: The observational relationship between obesity and periodontitis is widely known, yet causal evidence is lacking. Our objective was to investigate causal associations between periodontitis and body mass index (BMI). Methods: We performed Mendelian randomization analyses with BMI-associated loci combined in a genetic risk score (GRS) as the instrument for BMI. All analyses were conducted within the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium in 13 studies from Europe and the USA, including 49 066 participants with clinically assessed (seven studies, 42.1% of participants) and self-reported (six studies, 57.9% of participants) periodontitis and genotype data (17 672/31 394 with/without periodontitis); 68 761 participants with BMI and genotype data; and 57 871 participants (18 881/38 990 with/without periodontitis) with data on BMI and periodontitis. Results: In the observational meta-analysis of all participants, the pooled crude observational odds ratio (OR) for periodontitis was 1.13 [95% confidence interval (CI): 1.03, 1.24] per standard deviation increase of BMI. Controlling for potential confounders attenuated this estimate (OR = 1.08; 95% CI: 1.03, 1.12). For clinically assessed periodontitis, corresponding ORs were 1.25 (95% CI: 1.10, 1.42) and 1.13 (95% CI: 1.10, 1.17), respectively. In the genetic association meta-analysis, the OR for periodontitis was 1.01 (95% CI: 0.99, 1.03) per GRS unit (per one effect allele) in all participants and 1.00 (95% CI: 0.97, 1.03) in participants with clinically assessed periodontitis. The instrumental variable meta-analysis of all participants yielded an OR of 1.05 (95% CI: 0.80, 1.38) per BMI standard deviation, and 0.90 (95% CI: 0.56, 1.46) in participants with clinical data. Conclusions: Our study does not support total adiposity as a causal risk factor for periodontitis, as the point estimate is very close to the null in the causal inference analysis, with wide confidence intervals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Mendelian randomization
- BMI
- periodontitis
- casual inference
- confounding
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Shungin, Dmitry
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Cornelis, Marily ...
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Divaris, Kimon
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Holtfreter, Birt ...
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Shaffer, John R.
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Yu, Yau-Hua
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show more...
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Barros, Silvana ...
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Beck, James D.
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Biffar, Reiner
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Boerwinkle, Eric ...
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Crout, Richard J ...
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Ganna, Andrea
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Hallmans, Göran
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Hindy, George
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Hu, Frank B.
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Kraft, Peter
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McNeil, Daniel W ...
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Melander, Olle
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Moss, Kevin L.
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North, Kari E.
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Orho-Melander, M ...
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Pedersen, Nancy ...
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Ridker, Paul M.
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Rimm, Eric B.
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Rose, Lynda M.
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Rukh, Gull
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Teumer, Alexande ...
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Weyant, Robert J ...
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Chasman, Daniel ...
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Joshipura, Kaumu ...
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Kocher, Thomas
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Magnusson, Patri ...
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Marazita, Mary L ...
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Nilsson, Peter
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Offenbacher, Ste ...
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Smith, George Da ...
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Lundberg, Pernil ...
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Palmer, Tom M.
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Timpson, Nichola ...
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Johansson, Ingeg ...
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Franks, Paul W.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Nutrition and Di ...
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MEDICAL AND HEAL ...
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Umeå University
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Lund University
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Karolinska Institutet