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Sökning: WFRF:(Bitzer Michael)

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1.
  • 2019
  • Tidskriftsartikel (refereegranskat)
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2.
  • Catic, Amer, 1982, et al. (författare)
  • Automotive PLM - Applying a Product Design Mindset in PLM Implementation
  • 2009
  • Ingår i: Proceedings of 2nd Nordic Conference on Product Lifecycle Management - NordPLM '09.
  • Konferensbidrag (refereegranskat)abstract
    • This paper draws an analogy between product development and PLM development in order to address issues which have been observed in PLM development projects in two different automotive companies. In particular it applies ideas from the methodologies of VDI2221 and systems engineering to address issues in requirements management, functional design, top-down vs. bottom-up thinking and outsourcing. The main findings include that PLM development needs a higher level of “process as the customer” focus in order to manage the requirements. Related to these are also proposals regarding the funding and organization setup which need to reflect the customer focus. Other findings include a possibility to apply ideas from VDI2221 and systems engineering to increase architectural considerations and focus on functions rather than solutions when developing PLM. Regarding the issue of supplier management the authors propose the use of Technology Readiness Level to assess the maturity of PLM solutions before they are implemented. It is concluded that methods and models from product development can be used in PLM development and their application should also facilitate the communication between PLM developers and product developers.
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3.
  • Stenzinger, Albrecht, et al. (författare)
  • Trailblazing precision medicine in Europe : A joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany
  • 2022
  • Ingår i: Seminars in Cancer Biology. - : Elsevier. - 1044-579X .- 1096-3650. ; 84, s. 242-254
  • Tidskriftsartikel (refereegranskat)abstract
    • Over the last decades, rapid technological and scientific advances have led to a merge of molecular sciences and clinical medicine, resulting in a better understanding of disease mechanisms and the development of novel therapies that exploit specific molecular lesions or profiles driving disease. Precision oncology is here used as an example, illustrating the potential of precision/personalized medicine that also holds great promise in other medical fields. Real-world implementation can only be achieved by dedicated healthcare connected centers which amass and build up interdisciplinary expertise reflecting the complexity of precision medicine. Networks of such centers are ideally suited for a nation-wide outreach offering access to precision medicine to patients independent of their place of residence. Two of these multicentric initiatives, Genomic Medicine Sweden (GMS) and the Centers for Personalized Medicine (ZPM) initiative in Germany have teamed up to present and share their views on core concepts, potentials, challenges, and future developments in precision medicine. Together with other initiatives worldwide, GMS and ZPM aim at providing a robust and sustainable framework, covering all components from technology development to clinical trials, ethical and legal aspects as well as involvement of all relevant stakeholders, including patients and policymakers in the field.
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