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1.
  • Benderix, Ylva, 1953-, et al. (författare)
  • Barn med neuropsykiatriskt funktionshinder
  • 2009
  • Ingår i: PEDIATRISK OMVÅRDNAD. - Stockholm : LIBER. - 978-91-47-09327-4 ; s. 309-315
  • Bokkapitel (övrigt vetenskapligt)
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2.
  • Henoch, Ingela, et al. (författare)
  • The Swedish version of the Frommelt attitude toward care of the dying scale : Aspects of validity and factors influencing nurses' and nursing students' attitudes
  • 2014
  • Ingår i: Cancer Nursing. - Lippincott Williams & Wilkins. - 0162-220X. ; 37:1, s. E1-E11
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Nurses' attitudes toward caring for dying persons need to be explored. The Frommelt Attitude Toward Care of the Dying (FATCOD) scale has not previously been used in Swedish language. OBJECTIVES: The objectives of this study were to compare FATCOD scores among Swedish nurses and nursing students with those from other languages, to explore the existence of 2 subscales, and to evaluate influences of experiences on attitudes toward care of dying patients. METHODS: A descriptive, cross-sectional, and predictive design was used. The FATCOD scores of Swedish nurses from hospice, oncology, surgery clinics, and palliative home care and nursing students were compared with published scores from the United States, Israel, and Japan. Descriptive statistics, t tests, and factor and regression analyses were used. RESULTS: The sample consisted of 213 persons: 71 registered nurses, 42 enrolled nurses, and 100 nursing students. Swedish FATCOD mean scores did not differ from published means from the United States and Israel, but were significantly more positive than Japanese means. In line with Japanese studies, factor analyses yielded a 2-factor solution. Total FATCOD and subscales had low Cronbach α's. Hospice and palliative team nurses were more positive than oncology and surgery nurses to care for dying patients. CONCLUSIONS: Although our results suggest that the Swedish FATCOD may comprise 2 distinct scales, the total scale may be the most adequate and applicable for use in Sweden. Professional experience was associated with nurses' attitudes toward caring for dying patients. IMPLICATION FOR PRACTICE: Care culture might influence nurses' attitudes toward caring for dying patients; the benefits of education need to be explored.
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3.
  • Henoch, Ingela, et al. (författare)
  • The Swedish version of the Frommelt Attitude Toward Care of the Dying Scale (FATCOD) : Aspects of validity and factors influencing nurses' and nursing students' attitudes
  • 2014
  • Ingår i: Cancer Nursing. - 0162-220X. ; 37:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Nurses' attitudes toward caring for dying persons need to be explored. The Frommelt Attitude Toward Care of the Dying (FATCOD) scale has not previously been used in Swedish language.Objectives: The objectives of this study were to compare FATCOD scores among Swedish nurses and nursing students with those from other languages, to explore the existence of 2 subscales, and to evaluate influences of experiences on attitudes toward care of dying patients.Methods: A descriptive, cross-sectional, and predictive design was used. The FATCOD scores of Swedish nurses from hospice, oncology, surgery clinics, and palliative home care and nursing students were compared with published scores from the United States, Israel, and Japan. Descriptive statistics, t tests, and factor and regression analyses were used.Results: The sample consisted of 213 persons: 71 registered nurses, 42 enrolled nurses, and 100 nursing students. Swedish FATCOD mean scores did not differ from published means from the United States and Israel, but were significantly more positive than Japanese means. In line with Japanese studies, factor analyses yielded a 2-factor solution. Total FATCOD and subscales had low Cronbach [alpha]'s. Hospice and palliative team nurses were more positive than oncology and surgery nurses to care for dying patients.Conclusions: Although our results suggest that the Swedish FATCOD may comprise 2 distinct scales, the total scale may be the most adequate and applicable for use in Sweden. Professional experience was associated with nurses' attitudes toward caring for dying patients.Implication for Practice: Care culture might influence nurses' attitudes toward caring for dying patients; the benefits of education need to be explored.
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4.
  • Larsson, Margaretha, et al. (författare)
  • Altering the Parenting Role : Parents' Experience of Supporting the Health and Well-Being of Their Adolescent Girls
  • 2015
  • Ingår i: Child and Youth Care Forum. - Springer. - 1053-1890. ; 44:3, s. 419-432
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundIn research the relationships between parents and their adolescent daughters have been viewed from problem oriented perspectives, usually exploring negative effects and health-related problems. Health and well-being are complex phenomena and knowledge is needed on how parents can support the health and well-being of their daughter.ObjectivesThe aim of this study was to illuminate parents’ experiences of supporting the health and well-being of their adolescent girls.MethodsA descriptive design with a phenomenological approach including interviews, individually or in group with ten mothers and five fathers was conducted.ResultsSupporting the health and well-being of adolescent girls was experienced as challenging. The parents needed to altering the parenting role: from being the one who had previously set the limits they needed to rethink and be available for support. In this process interplay, communication and trust were important to support the health and well-being of the girls in an efficient way. This meaning was further illuminated by four constituents: Balancing the need for control, maintaining a trusting relationship, interplay to facilitate their daughters’ transition to independence, and an ambiguous parenting role.ConclusionsThis study highlights the importance of parents being involved in the everyday life of their adolescent daughter to support her health and well-being. The parents’ ability to contribute to the health and well-being of their girl seemed in this study dependent on their ability to communicate and alter the parenting role with sensitivity to the lifeworld of the adolescent girl.
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5.
  • Sjögren, Jonathan, et al. (författare)
  • EndoS and EndoS2 hydrolyze Fc-glycans on therapeutic antibodies with different glycoform selectivity and can be used for rapid quantification of high-mannose glycans.
  • 2015
  • Ingår i: Glycobiology. - Oxford University Press. - 1460-2423. ; 25:10, s. 1053-1063
  • Tidskriftsartikel (refereegranskat)abstract
    • Enzymes that affect glycoproteins of the human immune system, and thereby modulate defense responses, are abundant among bacterial pathogens. Two endoglycosidases from the human pathogen Streptococcus pyogenes, EndoS and EndoS2, have recently been shown to hydrolyze N-linked glycans of human IgG. However, detailed characterization and comparison of the hydrolyzing activities have not been performed. In the present study we set out to characterize the enzymes by comparing the activities of EndoS and EndoS2 on a selection of therapeutic monoclonal antibodies (mAbs), cetuximab, adalimumab, panitumumab, and denosumab. By analyzing the glycans hydrolyzed by EndoS and EndoS2 from the antibodies using MALDI-TOF, we found that both enzymes cleaved complex glycans, and that EndoS2 hydrolyzed hybrid and oligomannose structures to a greater extent compared to EndoS. A comparison of UHPLC profiles of the glycan pool of cetuximab hydrolyzed with EndoS and EndoS2 showed that EndoS2 hydrolyzed hybrid and oligomannose glycans whereas these peaks were missing in the EndoS chromatogram. We utilized this difference in glycoform selectivity and developed a liquid chromatography separation method to quantify high-mannose content in the Fc fragments of the selected mAbs. We conclude that EndoS and EndoS2 hydrolyze different glycoforms from the Fc-glycosylation site on therapeutic mAbs, and that this can be used for rapid quantification of high-mannose content.
6.
  • Sundler, Annelie Johansson, et al. (författare)
  • Living an Everyday Life Through a Child's Cancer Trajectory: Families' Lived Experiences 7 Years After Diagnosis
  • 2013
  • Ingår i: Journal of Pediatric Oncology Nursing. - SAGE Publications Inc.. - 1043-4542. ; 30:6, s. 293-300
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to illuminate the lived experiences of families where a child had survived 7 years from a diagnosis of childhood cancer. This article describes one part of an inductive and longitudinal research project that included 17 families. Four families whose child was diagnosed with cancer 7 years previously were interviewed using a hermeneutical phenomenological approach. The families lived experience was described in one essential theme, Living an everyday life through the child's cancer trajectory, further illuminated in 3 related themes: Leaving the disease behind yet feeling its presence, Being the same yet always different, and Feeling stronger yet vulnerable. The results suggest that family members feel vulnerable even if a long period of time has passed since completion of treatment. To varied degrees they still may need support. When moving forward in life, the family members are helped if they can reconcile their memories and experiences derived from the childhood cancer trajectory.
7.
  • Albin, Maria, et al. (författare)
  • Acute myeloid leukemia and clonal chromosome aberrations in relation to past exposure to organic solvents
  • 2000
  • Ingår i: Scandinavian Journal of Work, Environment and Health. - Finnish Institute of Occupational Health. - 0355-3140. ; 26:6, s. 482-491
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes. METHODS: Consecutively diagnosed cases of AML (N=333) and 1 population referent per case were retrospectively included in the study. Information on worktasks, companies, and leisure-time activities was obtained with telephone interviews. Exposure probability and intensity were assessed by occupational hygienists. Associations were evaluated with logistic regression. RESULTS: Exposure to organic solvents was associated with an increased risk of AML [low exposure: OR 1.5 (95% confidence interval (95% CI) 1.0-2.3, moderate-high exposure: OR 2.3 (95% CI 1.0-5.0)]. For exposure to solvents, but not to benzene, the OR was 1.2 (95% CI 0.69-2.0) for "low" and 2.7 (95% CI 1.0-7.3) for "moderate-high" exposure. The observed effects increased with intensity and duration of exposure. The estimated effects were higher for patients >60 years of age at the time of diagnosis. The effect of exposure to organic solvents was not differential with regard to morphology [except possibly erythroleukemia: OR 4.2, 95% CI 1.0-17 or the presence of CCA in general]. No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher risk was found for AML with trisomy 8 (OR 11, 95% CI 2.7-42) as the sole aberration. CONCLUSIONS: Exposure to organic solvents was associated with an increased risk of AML. This association was not due to benzene exposure alone and may be modified by age. Furthermore, specific associations with trisomy 8, and possibly also erythroleukemia, were suggested.
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8.
  • Albin, Maria; Björk, Jonas; Lövkvist, Håkan (författare)
  • Exponering för omgivningsbuller i Skåne: Omfattning och miljömedicinsk bedömning
  • 2003
  • Rapport (övrigt vetenskapligt)abstract
    • En kartläggning av exponering för omgivningsbuller i Skåne och en miljömedicinsk bedömning av dess effekter har genomförts. Som underlag har använts trafik på statliga vägar, med beräkningar baserade på GIS-metodik, samt modeller för vägbullerbelastning i tätorter av olika storlek från såväl statliga som kommunala vägar. Uppgifter om störning och hälsotillstånd har hämtats från Folkhälsoenkät Skåne 2000. Den övervägande delen av befolkningen (3 av 4) bor i områden som inte är tysta (ekvivalentnivå över 40 dB(A). Nära var femte person i Skåne beräknas vara utsatt för omgivningsbuller från vägtrafik överskridande 55 dB(A) ekvivalentnivå över dygnet. I Malmö och Burlöv beräknas minst var fjärde invånare ha sådan exponering. För tåg- och flygtrafik saknas underlag för motsvarande beräkningar. Det fanns bland personer som beräknades vara exponerade över dessa nivåer en tendens till att oftare rapportera koncentrationsstörning. För personer som i större utsträckning kan antas vistas och arbeta hemma dagtid (hemarbetande, pensionärer, studerande, arbetslösa) var ökningen statistiskt signifikant (Oddskvot=3,5, 95% konfidensintervall 1,3-8.9), medan ingen effekt sågs hos de förvärvsarbetande. Inga statistiskt säkerställda samband sågs med sömnstörning eller blodtrycksmedicinering. Trafikbuller i bostaden upplevs som ganska mycket, eller mycket störande av var femtonde person i Skåne (7%). Flertalet av dessa, motsvarande 5% i hela befolkningen, anger att det är vägtrafiken som stör dem. Motsvarande 2-3% av befolkningen anger att trafikbullret ofta ger störd vila/avkoppling, insomning, respektive väckning. Kartläggningen visar att underlaget för hälsorelaterad miljöövervakning av exponering för trafikbuller är bristfälligt i flera avseenden. Trots detta visar kartläggningen att exponeringen för trafikbuller är ett betydande problem för befolkningen i Skåne. Problemet är särskilt uttalat i vissa kommuner där riktade insatser är befogade. Det är ur miljömedicinsk synpunkt angeläget att underlaget för fortsatt miljöövervakning av exponering för trafikbuller förbättras och därefter fortsatt uppdateras, med god tillgänglighet för olika samhällsinstanser.
9.
  • Albin, Maria, et al. (författare)
  • Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures.
  • 2003
  • Ingår i: Scandinavian Journal of Work, Environment and Health. - Finnish Institute of Occupational Health. - 0355-3140. ; 29:5, s. 378-387
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: This study investigated the association between occupational and hobby exposure and the risk of myelodysplastic syndromes (MDS) while focusing on differential patterns of clonal chromosome aberrations and morphologic subgroups. METHODS: A case-referent study was conducted with 330 MDS patients investigated cytogenetically in 1976-1993 (cases) and matched referents. Telephone interviews with either the person or a next-of-kin were used. The participation rate of the cases and referents was 85% and 60%, respectively. Information was obtained from the next-of-kin more often for the cases (88%) than for the referents (26%). Occupational hygienists assessed the exposure using interview data on worktasks and hobbies. Associations with disease risk were evaluated for 10 exposures with a logistic regression analysis. RESULTS: The investigated exposures were generally not associated with cytogenetically abnormal MDS. Effect estimates for specific cytogenetic or morphologic subgroups were generally imprecise. Occupational exposure to extremely low-frequency magnetic fields (EMF) was associated with MDS with a normal karyotype [odds ratio (OR) 2.0, 95% confidence interval (95% CI) 1.0-4.0]. The exposure-response association was consistent for intensity but inconclusive for duration. A decreased risk was observed for MDS, irrespective of karyotypic pattern, among farmers and farmhands (OR 0.53, 95% CI 0.35-0.81). CONCLUSIONS: Cytogenetically abnormal MDS was generally not associated with occupational or hobby exposure to known or suspected genotoxic agents. However, exposure prevalences and intensities were low for several agents. An association was suggested between occupational exposure to EMF and MDS with a normal karyotype. Biases due to differential information quality and selective participation cannot be ruled out.
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10.
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